Choriocapillaris dropout in early age-related macular degeneration

• Published in: Experimental eye research Vol. 192; p. 107939
• Main Authors: Lutty, Gerard A., McLeod, D. Scott, Bhutto, Imran A., Edwards, Malia M., Seddon, Johanna M.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.03.2020
• Subjects: Age-related macular degeneration; Aged; Aged, 80 and over; Basal laminar deposit; Choriocapillaris; Choroid - blood supply; Choroidal neovascularization; Choroidal Neovascularization - pathology; Ciliary Arteries - pathology; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Female; Humans; Hypertension; Immunohistochemistry; Macular Degeneration - pathology; Male; Microscopy, Confocal; Plant Lectins - metabolism; Retinal Drusen - pathology; Staining and Labeling; Tissue Donors; Visual Acuity - physiology; Hypertension; Choriocapillaris; Choroidal neovascularization; Basal laminar deposit; Age-related macular degeneration

Loss of choriocapillaris (CC) in advanced age-related macular degeneration (AMD) is well documented but changes in early AMD have not been quantified. Postmortem eyes from donors with clinically documented early AMD were examined in choroidal whole mounts to determine the area, pattern, and severity...