Assessing the Biocompatibility of Multi-Anchored Glycoconjugate Functionalized Iron Oxide Nanoparticles in a Normal Human Colon Cell Line CCD-18Co

• Published in: Nanomaterials (Basel, Switzerland) Vol. 11; no. 10; p. 2465
• Main Authors: Raval, Yash S., Samstag, Anna, Taylor, Cedric, Huang, Guohui, Mefford, Olin Thompson, Tzeng, Tzuen-Rong Jeremy
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 22.09.2021; MDPI
• Subjects: Adenosine triphosphate; Antibacterial agents; Antiinfectives and antibacterials; ATP; ATP synthase; Biocompatibility; Cancer; Caspase-3; Cell morphology; Cell proliferation; Cell viability; Chromatography; Colon; colon cell toxicity; Cytology; Cytotoxicity; Dopamine; Drug dosages; E coli; Evaluation; Fourier transforms; Glutathione; glycoconjugates; Integrity; Intracellular; iron oxide nanoparticles; Iron oxides; Irritable bowel syndrome; Ligands; magnetic nanoparticles; Membranes; Morphology; Nanomaterials; nanoparticle cellular uptake; Nanoparticles; NMR; Nuclear magnetic resonance; Polyethylene; Polyethylene glycol; Polyethylene oxide; Polymers; Surface chemistry; Toxicity; United States > US; Grand Island New York

We have previously demonstrated that iron oxide nanoparticles with dopamine-anchored heterobifunctional polyethylene oxide (PEO) polymer, namely PEO-IONPs, and bio-functionalized with sialic-acid specific glycoconjugate moiety (Neu5Ac(α2-3)Gal(β1-4)-Glcβ-sp), namely GM3-IONPs, can be effectively use...