Endothelial ganglioside GM3 regulates angiogenesis in solid tumors

• Published in: Biochemical and biophysical research communications Vol. 569; pp. 10 - 16
• Main Authors: Suzuki, Mira, Nagane, Masaki, Kato, Kazuhiro, Yamauchi, Akinori, Shimizu, Takuto, Yamashita, Hiroko, Aihara, Naoyuki, Kamiie, Junichi, Kawashima, Nagako, Naito, Shokichi, Yamashita, Tadashi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 10.09.2021
• Subjects: Angiogenesis; Animals; breast neoplasms; Cattle; Cell Line, Tumor; Cell Survival - genetics; Cells, Cultured; Endothelial cell; Endothelial Cells - metabolism; G(M3) Ganglioside - metabolism; Ganglioside; gangliosides; humans; Kaplan-Meier Estimate; Mammary Neoplasms, Experimental - blood supply; Mammary Neoplasms, Experimental - genetics; Mammary Neoplasms, Experimental - metabolism; Mice, Inbred C57BL; Mice, Knockout; N-Acetylgalactosaminyltransferases - genetics; N-Acetylgalactosaminyltransferases - metabolism; Neovascularization, Pathologic - genetics; Neovascularization, Pathologic - metabolism; Oxidative stress; oxygen; Polypeptide N-acetylgalactosaminyltransferase; RNA interference; Sialyltransferases - genetics; Sialyltransferases - metabolism; signal transduction; stress tolerance; Tumor; Tumor Burden - genetics; Angiogenesis; Oxidative stress; Endothelial cell; Ganglioside; LacCer; GM3S; Tumor; GlcCer; GD3S; GalNAcT1

Cancer cells require oxygen and nutrients for growth, making angiogenesis one of the essential components of tumor growth. Gangliosides, constituting membrane lipid rafts, regulate intracellular signal transduction and are involved in the malignancy of cancer cells. While endothelial cells, as well...