Unique Mutations in Mitochondrial DNA of Senescence-Accelerated Mouse (SAM) Strains

• Published in: The Journal of heredity Vol. 92; no. 4; pp. 352 - 355
• Main Authors: Mizutani, J., Chiba, T., Tanaka, M., Higuchi, K., Mori, M.
• Format: Journal Article
• Language: English
• Published: United States Oxford University Press 01.07.2001; Oxford Publishing Limited (England)
• Subjects: Aging - genetics; Aging, Premature - genetics; Animals; Consensus Sequence; Deoxyribonucleic acid; DNA; DNA, Mitochondrial; Genes; Genetics; Heredity; Mice; Mice, Inbred Strains; Mitochondria - genetics; Mitochondria - physiology; Molecular Sequence Data; Mutation; Polymerase Chain Reaction; Polymorphism, Genetic; Rodents

Mitochondrial DNA (mtDNA) is exclusively inherited maternally and hence could offer a good method for tracing the lineage of mouse strains. We examined the mtDNA sequence of senescence-accelerated mouse (SAM) strains as well as other laboratory strains of inbred mice to deduce the ancestral strain o...