Urinary oxalate and glycolate excretion patterns in the first year of life: A longitudinal study

• Published in: The Journal of pediatrics Vol. 123; no. 2; pp. 248 - 251
• Main Authors: Morgenstern, Bruce Z., Milliner, Dawn S., Murphy, Mary E., Simmons, Patricia S., Moyer, Thomas P., Wilson, David M., Smith, Lynwood H.
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.08.1993; Elsevier
• Subjects: Biological and medical sciences; Creatinine - urine; Fundamental and applied biological sciences. Psychology; Glycolates - urine; Humans; Infant; Infant Food; Infant, Newborn; Longitudinal Studies; Metabolisms and neurohumoral controls; Milk, Human; Oxalates - urine; Prospective Studies; Reference Values; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Water and mineral metabolism. Osmoregulation. Acidobasic balance; Creatinine; Excretion; Follow up study; Oxalate; Cohort study; Reference; Mean value; Standards
• ISSN: 0022-3476; 1097-6833
• DOI: 10.1016/S0022-3476(05)81696-8

To determine the range of normal values, we studied urinary excretion of oxalate and glycolate prospectively and longitudinally in a cohort of 30 healthy term infants. Random urine samples were obtained at 2 days, 2 weeks, and 2, 4, 6, and 9 months of age. The results had a log-normal distribution. The mean oxalate/cretinine ratio, as determined by the oxalate oxidasee method, was 0.08 (in milligrams of oxalate to milligrams of creatinine) with a normalized range of 0.02 to 0.31. The mean ratio when oxalates were measured by using the Olthuis assay was 0.13 (range 0.03 to 0.53). The mean glycolate/creatinine ratio was 0.07 (range 0.02 to 0.26). These values did not correlate with increasing age. The oxalate/creatinine ratios were higher in formula-fed infants than in those who were fed human milk (0.14±0.16 vs 0.08±0.04; p<0.01).