Emerging Role of Circular RNA–Protein Interactions

Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-t...

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Published inNon-coding RNA Vol. 7; no. 3; p. 48
Main Authors Das, Arundhati, Sinha, Tanvi, Shyamal, Sharmishtha, Panda, Amaresh Chandra
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 04.08.2021
MDPI
Subjects
Binding sites
Biosynthesis
circRNA
Circular RNA
decoy
Gene expression
Localization
MicroRNAs
miRNA
mRNA stability
Nuclear transport
Physiology
Protein interaction
Proteins
Review
RNA transport
RNA-binding protein
splicing
translation
Online AccessGet full text
ISSN2311-553X
2311-553X
DOI10.3390/ncrna7030048

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Abstract Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA–protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered circRNAs. RBPs are a large family of proteins known to play a critical role in gene expression by modulating RNA splicing, nuclear export, mRNA stability, localization, and translation. However, the interaction of RBPs with circRNAs and their implications on circRNA biogenesis and function has been emerging in the last few years. Recent studies suggest that circRNA interaction with target proteins modulates the interaction of the protein with downstream target mRNAs or proteins. This review outlines the emerging mechanisms of circRNA–protein interactions and their functional role in cell physiology.
AbstractList Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA–protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered circRNAs. RBPs are a large family of proteins known to play a critical role in gene expression by modulating RNA splicing, nuclear export, mRNA stability, localization, and translation. However, the interaction of RBPs with circRNAs and their implications on circRNA biogenesis and function has been emerging in the last few years. Recent studies suggest that circRNA interaction with target proteins modulates the interaction of the protein with downstream target mRNAs or proteins. This review outlines the emerging mechanisms of circRNA–protein interactions and their functional role in cell physiology.
Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA-protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered circRNAs. RBPs are a large family of proteins known to play a critical role in gene expression by modulating RNA splicing, nuclear export, mRNA stability, localization, and translation. However, the interaction of RBPs with circRNAs and their implications on circRNA biogenesis and function has been emerging in the last few years. Recent studies suggest that circRNA interaction with target proteins modulates the interaction of the protein with downstream target mRNAs or proteins. This review outlines the emerging mechanisms of circRNA-protein interactions and their functional role in cell physiology.Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting with cellular regulators such as microRNAs and RNA binding proteins (RBPs) to regulate downstream gene expression. The accumulation of high-throughput RNA-protein interaction data revealed the interaction of RBPs with the coding and noncoding RNAs, including recently discovered circRNAs. RBPs are a large family of proteins known to play a critical role in gene expression by modulating RNA splicing, nuclear export, mRNA stability, localization, and translation. However, the interaction of RBPs with circRNAs and their implications on circRNA biogenesis and function has been emerging in the last few years. Recent studies suggest that circRNA interaction with target proteins modulates the interaction of the protein with downstream target mRNAs or proteins. This review outlines the emerging mechanisms of circRNA-protein interactions and their functional role in cell physiology.
Author Das, Arundhati
Sinha, Tanvi
Panda, Amaresh Chandra
Shyamal, Sharmishtha
AuthorAffiliation 1 Institute of Life Sciences, Nalco Square, Bhubaneswar 751023, India; arundhati.s@ils.res.in (A.D.); tanvi@ils.res.in (T.S.); sharmishtha@ils.res.in (S.S.)
2 School of Biotechnology, KIIT University, Bhubaneswar 751024, India
AuthorAffiliation_xml – name: 2 School of Biotechnology, KIIT University, Bhubaneswar 751024, India
– name: 1 Institute of Life Sciences, Nalco Square, Bhubaneswar 751023, India; arundhati.s@ils.res.in (A.D.); tanvi@ils.res.in (T.S.); sharmishtha@ils.res.in (S.S.)
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  surname: Panda
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Snippet Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various biological processes. CircRNAs regulate gene expression by interacting...
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StartPage 48
SubjectTerms Binding sites
Biosynthesis
circRNA
Circular RNA
decoy
Gene expression
Localization
MicroRNAs
miRNA
mRNA stability
Nuclear transport
Physiology
Protein interaction
Proteins
Review
RNA transport
RNA-binding protein
splicing
translation
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Title Emerging Role of Circular RNA–Protein Interactions
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