Arginine-induced insulin secretion in endoplasmic reticulum

• Published in: Biochemical and biophysical research communications Vol. 466; no. 4; pp. 717 - 722
• Main Authors: Umeda, Makoto, Hiramoto, Masaki, Watanabe, Atsushi, Tsunoda, Nobuyo, Imai, Takeshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 30.10.2015
• Subjects: agarose; Animals; Arginine; Arginine - metabolism; Arginine - pharmacology; Biomimetic Materials - pharmacology; Brazilian propolis; calnexin; Calnexin - pharmacology; Cell Line; Diabetes mellitus; Endoplasmic reticulum; Endoplasmic Reticulum - metabolism; Glucose; Insulin; Insulin - metabolism; Insulin Secretion; Insulin-Secreting Cells - drug effects; Insulin-Secreting Cells - metabolism; Mice; Nanotechnology; proinsulin; Proinsulin - metabolism; propolis; Propolis - pharmacology; screening; T2DM; FK; Diabetes mellitus; IP; PKA; Brazilian propolis; DM; Glucose; Akt; WB; CNX; Insulin; ER; Ins; GPRC6A; NOS; Arginine; PMSF; OE; Arg; FCS; Endoplasmic reticulum

Arginine, a semi-essential amino acid, is known as one of the most strongest insulin secretagogues in a glucose-dependent manner, but major mechanism is unknown. Arginine induced insulin secretion in mice as well as β cell line, NIT-1, in which more than 90% of intracellular insulin is prionsulin wi...