Vaccine delivery systems toward lymph nodes

Vaccines play an important role in the control and prevention of human infectious diseases such as the ongoing COVID-19 pandemic. The successful vaccination needs to effectively deliver antigenic substances to induce a strong protective or therapeutic immune response. In this review, the lymph node...

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Published inAdvanced drug delivery reviews Vol. 179; p. 113914
Main Authors Ding, Yingyue, Li, Zhaoting, Jaklenec, Ana, Hu, Quanyin
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.12.2021
Subjects
Adaptive Immunity - immunology
Antigens - metabolism
Delivery barriers
Drug Administration Routes
Drug Delivery Systems - methods
Humans
Immune response
Lymph nodes
Lymph Nodes - immunology
Lymph Nodes - physiology
Lymphocytes
Nanoparticle Drug Delivery System - chemistry
Targeted delivery
Vaccine
Vaccines - administration & dosage
Vaccines - immunology
Vaccine
Delivery barriers
Immune response
Targeted delivery
Lymphocytes
Lymph nodes
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Abstract Vaccines play an important role in the control and prevention of human infectious diseases such as the ongoing COVID-19 pandemic. The successful vaccination needs to effectively deliver antigenic substances to induce a strong protective or therapeutic immune response. In this review, the lymph node structure, the administration routes and the most popular vaccine delivery systems together with their applications are carefully summarized with a special focus on the designing of the vaccine delivery strategies to overcome the barriers and strengthen the immune response against infectious diseases. [Display omitted] Strategies of improving vaccine targeting ability toward lymph nodes have been attracting considerable interest in recent years, though there are remaining delivery barriers based on the inherent properties of lymphatic systems and limited administration routes of vaccination. Recently, emerging vaccine delivery systems using various materials as carriers are widely developed to achieve efficient lymph node targeting and improve vaccine-triggered adaptive immune response. In this review, to further optimize the vaccine targeting ability for future research, the design principles of lymph node targeting vaccine delivery based on the anatomy of lymph nodes and vaccine administration routes are first summarized. Then different designs of lymph node targeting vaccine delivery systems, including vaccine delivery systems in clinical applications, are carefully surveyed. Also, the challenges and opportunities of current delivery systems for vaccines are concluded in the end.
AbstractList Vaccines play an important role in the control and prevention of human infectious diseases such as the ongoing COVID-19 pandemic. The successful vaccination needs to effectively deliver antigenic substances to induce a strong protective or therapeutic immune response. In this review, the lymph node structure, the administration routes and the most popular vaccine delivery systems together with their applications are carefully summarized with a special focus on the designing of the vaccine delivery strategies to overcome the barriers and strengthen the immune response against infectious diseases. [Display omitted] Strategies of improving vaccine targeting ability toward lymph nodes have been attracting considerable interest in recent years, though there are remaining delivery barriers based on the inherent properties of lymphatic systems and limited administration routes of vaccination. Recently, emerging vaccine delivery systems using various materials as carriers are widely developed to achieve efficient lymph node targeting and improve vaccine-triggered adaptive immune response. In this review, to further optimize the vaccine targeting ability for future research, the design principles of lymph node targeting vaccine delivery based on the anatomy of lymph nodes and vaccine administration routes are first summarized. Then different designs of lymph node targeting vaccine delivery systems, including vaccine delivery systems in clinical applications, are carefully surveyed. Also, the challenges and opportunities of current delivery systems for vaccines are concluded in the end.
Vaccines play an important role in the control and prevention of human infectious diseases such as the ongoing COVID-19 pandemic. The successful vaccination needs to effectively deliver antigenic substances to induce a strong protective or therapeutic immune response. In this review, the lymph node structure, the administration routes and the most popular vaccine delivery systems together with their applications are carefully summarized with a special focus on the designing of the vaccine delivery strategies to overcome the barriers and strengthen the immune response against infectious diseases. Strategies of improving vaccine targeting ability toward lymph nodes have been attracting considerable interest in recent years, though there are remaining delivery barriers based on the inherent properties of lymphatic systems and limited administration routes of vaccination. Recently, emerging vaccine delivery systems using various materials as carriers are widely developed to achieve efficient lymph node targeting and improve vaccine-triggered adaptive immune response. In this review, to further optimize the vaccine targeting ability for future research, the design principles of lymph node targeting vaccine delivery based on the anatomy of lymph nodes and vaccine administration routes are first summarized. Then different designs of lymph node targeting vaccine delivery systems, including vaccine delivery systems in clinical applications, are carefully surveyed. Also, the challenges and opportunities of current delivery systems for vaccines are concluded in the end.
Strategies of improving vaccine targeting ability toward lymph nodes have been attracting considerable interest in recent years, though there are remaining delivery barriers based on the inherent properties of lymphatic systems and limited administration routes of vaccination. Recently, emerging vaccine delivery systems using various materials as carriers are widely developed to achieve efficient lymph node targeting and improve vaccine-triggered adaptive immune response. In this review, to further optimize the vaccine targeting ability for future research, the design principles of lymph node targeting vaccine delivery based on the anatomy of lymph nodes and vaccine administration routes are first summarized. Then different designs of lymph node targeting vaccine delivery systems, including vaccine delivery systems in clinical applications, are carefully surveyed. Also, the challenges and opportunities of current delivery systems for vaccines are concluded in the end.Strategies of improving vaccine targeting ability toward lymph nodes have been attracting considerable interest in recent years, though there are remaining delivery barriers based on the inherent properties of lymphatic systems and limited administration routes of vaccination. Recently, emerging vaccine delivery systems using various materials as carriers are widely developed to achieve efficient lymph node targeting and improve vaccine-triggered adaptive immune response. In this review, to further optimize the vaccine targeting ability for future research, the design principles of lymph node targeting vaccine delivery based on the anatomy of lymph nodes and vaccine administration routes are first summarized. Then different designs of lymph node targeting vaccine delivery systems, including vaccine delivery systems in clinical applications, are carefully surveyed. Also, the challenges and opportunities of current delivery systems for vaccines are concluded in the end.
Strategies of improving vaccine targeting ability toward lymph nodes have been attracting considerable interest in recent years, though there are remaining delivery barriers based on the inherent properties of lymphatic systems and limited administration routes of vaccination. Recently, emerging vaccine delivery systems using various materials as carriers are widely developed to achieve efficient lymph node targeting and improve vaccine-triggered adaptive immune response. In this review, to further optimize the vaccine targeting ability for future research, the design principles of lymph node targeting vaccine delivery based on the anatomy of lymph nodes and vaccine administration routes are first summarized. Then different designs of lymph node targeting vaccine delivery systems, including vaccine delivery systems in clinical applications, are carefully surveyed. Also, the challenges and opportunities of current delivery systems for vaccines are concluded in the end.
ArticleNumber 113914
Author Li, Zhaoting
Jaklenec, Ana
Hu, Quanyin
Ding, Yingyue
Author_xml – sequence: 1
  givenname: Yingyue
  surname: Ding
  fullname: Ding, Yingyue
  organization: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, United States
– sequence: 2
  givenname: Zhaoting
  surname: Li
  fullname: Li, Zhaoting
  organization: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, United States
– sequence: 3
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  surname: Jaklenec
  fullname: Jaklenec, Ana
  organization: Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02142, United States
– sequence: 4
  givenname: Quanyin
  surname: Hu
  fullname: Hu, Quanyin
  email: qhu66@wisc.edu
  organization: Pharmaceutical Sciences Division, School of Pharmacy, University of Wisconsin-Madison, Madison, WI 53705, United States
BackLink https://www.ncbi.nlm.nih.gov/pubmed/34363861$$D View this record in MEDLINE/PubMed
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IngestDate Thu Aug 21 18:28:16 EDT 2025
Thu Jul 10 23:09:27 EDT 2025
Wed Feb 19 02:25:39 EST 2025
Tue Jul 01 03:36:07 EDT 2025
Thu Apr 24 22:55:59 EDT 2025
Fri Feb 23 02:46:03 EST 2024
IsDoiOpenAccess true
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Keywords Vaccine
Delivery barriers
Immune response
Targeted delivery
Lymphocytes
Lymph nodes
Language English
License Copyright © 2021 Elsevier B.V. All rights reserved.
Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
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content type line 23
Yingyue Ding and Zhaoting Li contributed equally to this work.
OpenAccessLink https://pubmed.ncbi.nlm.nih.gov/PMC9418125
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PublicationTitle Advanced drug delivery reviews
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Snippet Vaccines play an important role in the control and prevention of human infectious diseases such as the ongoing COVID-19 pandemic. The successful vaccination...
Strategies of improving vaccine targeting ability toward lymph nodes have been attracting considerable interest in recent years, though there are remaining...
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SubjectTerms Adaptive Immunity - immunology
Antigens - metabolism
Delivery barriers
Drug Administration Routes
Drug Delivery Systems - methods
Humans
Immune response
Lymph nodes
Lymph Nodes - immunology
Lymph Nodes - physiology
Lymphocytes
Nanoparticle Drug Delivery System - chemistry
Targeted delivery
Vaccine
Vaccines - administration & dosage
Vaccines - immunology
Title Vaccine delivery systems toward lymph nodes
URI https://dx.doi.org/10.1016/j.addr.2021.113914
https://www.ncbi.nlm.nih.gov/pubmed/34363861
https://www.proquest.com/docview/2559434097
https://pubmed.ncbi.nlm.nih.gov/PMC9418125
Volume 179
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