Potential role for age as a modulator of oral nitrate reductase activity

• Published in: Nitric oxide Vol. 108; pp. 1 - 7
• Main Authors: Ahmed, Khandaker Ahtesham, Kim, Kiyoung, Ricart, Karina, Van Der Pol, William, Qi, Xiaoping, Bamman, Marcas M., Behrens, Christian, Fisher, Gordon, Boulton, Michael E., Morrow, Casey, O'Neal, Pamela V., Patel, Rakesh P.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2021
• Subjects: Adult; Age Factors; Aged; Aging; Animals; Bacteria - enzymology; Bacterial Proteins - metabolism; Cross-Sectional Studies; Female; Humans; Male; Mice; Mice, Inbred C57BL; Microbiome; Microbiota - physiology; Middle Aged; Nitrate Reductase - metabolism; Nitrates - metabolism; Nitric oxide; Nitrites - blood; Nitrites - metabolism; Tongue - microbiology; Young Adult; Aging; Nitric oxide; Microbiome

Reduction of salivary nitrate to nitrite by oral nitrate reductase (NR) expressing bacteria has emerged as an integral pathway in regulating nitric oxide (NO) homeostasis and signaling. The oral microbiome is critical for this pathway. Variations in this pathway may underlie variable responses in th...