Site-Specific and Common Prostate Cancer Metastasis Genes as Suggested by Meta-Analysis of Gene Expression Data

• Published in: Life (Basel, Switzerland) Vol. 11; no. 7; p. 636
• Main Author: Samaržija, Ivana
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 30.06.2021; MDPI
• Subjects: Androgen receptors; Androgens; Biomarkers; bone metastasis; Bones; Chemokines; Datasets; Filaments; Gene expression; Genes; Liver; liver metastasis; lymph node metastasis; Lymph nodes; Lymphatic system; Meta-analysis; Metastases; Metastasis; Muscle contraction; Perturbation; Prognosis; Prostate cancer; Proteins; Signal transduction; Signaling; Smooth muscle; Software; Survival analysis; Transcription; Tumors

Anticancer therapies mainly target primary tumor growth and little attention is given to the events driving metastasis formation. Metastatic prostate cancer, in comparison to localized disease, has a much worse prognosis. In the work presented here, groups of genes that are common to prostate cancer...