Migrating motor complex of the intestine and absorption of a biliary excreted drug in the dog

• Published in: The Journal of pharmacology and experimental therapeutics Vol. 267; no. 3; pp. 1161 - 1167
• Main Authors: Priymenko, N, Ferre, J P, Rascol, A, Costes, G, Toutain, P L
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Elsevier Inc 01.12.1993; American Society for Pharmacology and Experimental Therapeutics
• Subjects: Animals; Anti-Inflammatory Agents, Non-Steroidal - blood; Anti-Inflammatory Agents, Non-Steroidal - metabolism; Anti-Inflammatory Agents, Non-Steroidal - pharmacokinetics; Bile - metabolism; Biliary Tract - metabolism; Biological and medical sciences; Biological Availability; Bones, joints and connective tissue. Antiinflammatory agents; Dogs; Duodenum - metabolism; Duodenum - physiology; Female; Gastrointestinal Motility - physiology; Hydrolysis; Ileum - metabolism; Ileum - physiology; Injections, Intraperitoneal; Injections, Intravenous; Intestinal Absorption - physiology; Intestine, Small - metabolism; Intestine, Small - physiology; Life Sciences; Male; Medical sciences; Models, Biological; Motor Activity - physiology; ortho-Aminobenzoates - blood; ortho-Aminobenzoates - metabolism; ortho-Aminobenzoates - pharmacokinetics; Pharmacology. Drug treatments; Fissipedia; Carnivora; Digestive system; Gut; Clearance; Enteral administration; Non steroidal antiinflammatory agent; Migrating myoelectric complex; Vertebrata; Mammalia; Absorption; Animal; Conjugated compound; Pharmacokinetics; Dog; Bile; ILEUM; ABSORPTION INTESTINALE

The role of the migrating motor complex (MMC) of the small intestine in the absorption of an enterally administered marker (tolfenamic acid, TA) used to investigate enterohepatic recycling was studied in the fasted dog. TA was rapidly and extensively absorbed in the duodenum as well as in the ileum....