Abemaciclib and Vacuolin-1 induce vacuole-like autolysosome formation – A new tool to study autophagosome-lysosome fusion

• Published in: Biochemical and biophysical research communications Vol. 614; pp. 191 - 197
• Main Authors: Tanaka, Yoshinori, Hino, Hirotsugu, Takeya, Kosuke, Eto, Masumi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 23.07.2022
• Subjects: Abemaciclib; Aminopyridines; Autolysosome; autophagosomes; Autophagosomes - metabolism; Autophagy; Benzimidazoles; breast neoplasms; endosomes; Heterocyclic Compounds, 4 or More Rings; lysosomes; Lysosomes - metabolism; Macroautophagy; Progranulin; Progranulins - metabolism; rapamycin; Vacuolation; vacuoles; Vacuoles - metabolism; Vacuolin-1; Autolysosome; Abemaciclib; Progranulin; Vacuolin-1; Vacuolation

Macroautophagy (hereafter autophagy) is a conserved cellular degradation system, impairments in which have been implicated in the development of a wide range of diseases, including cancer and neurodegenerative diseases. Autophagy is mainly comprised of two processes: the formation of autophagosomes...