Mitochondrial Metabolism as a Target for Cancer Therapy

• Published in: Cell metabolism Vol. 32; no. 3; pp. 341 - 352
• Main Authors: Vasan, Karthik, Werner, Marie, Chandel, Navdeep S.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2020
• Subjects: Animals; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Humans; metformin; mitochondria; Mitochondria - drug effects; Mitochondria - metabolism; Neoplasms - drug therapy; Neoplasms - metabolism; metformin; mitochondria

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism by providing key metabolites for macromolecule synthesis and generating oncometabolites to maintain the cancer phenotype. M...