Mitochondrial Metabolism as a Target for Cancer Therapy

Recent evidence in humans and mice supports the notion that mitochondrial metabolism is active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism by providing key metabolites for macromolecule synthesis and generating oncometabolites to maintain the cancer phenotype. M...

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Bibliographic Details
Published inCell metabolism Vol. 32; no. 3; pp. 341 - 352
Main Authors Vasan, Karthik, Werner, Marie, Chandel, Navdeep S.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.09.2020
Subjects
Animals
Antineoplastic Agents - chemistry
Antineoplastic Agents - pharmacology
Humans
metformin
mitochondria
Mitochondria - drug effects
Mitochondria - metabolism
Neoplasms - drug therapy
Neoplasms - metabolism
metformin
mitochondria
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Summary:Recent evidence in humans and mice supports the notion that mitochondrial metabolism is active and necessary for tumor growth. Mitochondrial metabolism supports tumor anabolism by providing key metabolites for macromolecule synthesis and generating oncometabolites to maintain the cancer phenotype. Moreover, there are multiple clinical trials testing the efficacy of inhibiting mitochondrial metabolism as a new cancer therapeutic treatment. In this review, we discuss the rationale of using these anti-cancer agents in clinical trials and highlight how to effectively utilize them in different tumor contexts. Recent evidence indicates that mitochondrial metabolism is essential for tumorigenesis. Vasan et al. review multiple mitochondrial drugs in clinical trials for various cancers, including metformin. Also, they report a genetic screen highlighting mechanisms of resistance to metformin.
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ISSN:1550-4131
1932-7420
1932-7420
DOI:10.1016/j.cmet.2020.06.019