Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality

This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median ef...

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Published inToxicon X Vol. 14; p. 100124
Main Authors Okumu, Mitchel Otieno, Mbaria, James Mucunu, Gikunju, Joseph Kangangi, Mbuthia, Paul Gichohi, Madadi, Vincent Odongo, Ochola, Francis Okumu, Maloba, Kenneth Narotso, Nderitu, Joseph Gichuki
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2022
Elsevier
Subjects
Antivenoms
Clinical studies, antivenoms and epidemiology
Naja ashei
Neutralization
Potency
Snakebite
Snakebite
Antivenoms
Potency
Naja ashei
Neutralization
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Abstract This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV). [Display omitted] •Naja ashei venom (NAV) has an i.p. LD50 of 3.02 (2.45–3.72) μg/g in mice.•Vins bioproducts antivenom has poor efficacy against NAV-induced lethality.•Inoserp and South African Institute of Medical Research polyvalent antivenoms have high potency in NAV-induced lethality.
AbstractList This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).
This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of venom (NAV).
This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV).
This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV). Image 1 • Naja ashei venom (NAV) has an i.p. LD 50 of 3.02 (2.45–3.72) μg/g in mice. • Vins bioproducts antivenom has poor efficacy against NAV-induced lethality. • Inoserp and South African Institute of Medical Research polyvalent antivenoms have high potency in NAV-induced lethality.
This study aimed to determine the efficacy of Inoserp, Vins bioproducts, and South African Institute of Medical Research (SAIMR) polyvalent antivenoms in neutralizing Naja ashei venom-induced lethality in mice. The neutralization efficacy of the antivenoms were expressed as effective dose, median effective ratio, potency, normalized potency, volume, and the number of vials of antivenom required to neutralize 100 mg of Naja ashei venom (NAV). [Display omitted] •Naja ashei venom (NAV) has an i.p. LD50 of 3.02 (2.45–3.72) μg/g in mice.•Vins bioproducts antivenom has poor efficacy against NAV-induced lethality.•Inoserp and South African Institute of Medical Research polyvalent antivenoms have high potency in NAV-induced lethality.
ArticleNumber 100124
Author Mbuthia, Paul Gichohi
Nderitu, Joseph Gichuki
Madadi, Vincent Odongo
Okumu, Mitchel Otieno
Maloba, Kenneth Narotso
Gikunju, Joseph Kangangi
Mbaria, James Mucunu
Ochola, Francis Okumu
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  givenname: Joseph Kangangi
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  givenname: Francis Okumu
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  givenname: Kenneth Narotso
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Keywords Snakebite
Antivenoms
Potency
Naja ashei
Neutralization
Language English
License This is an open access article under the CC BY-NC-ND license.
2022 The Authors.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
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SubjectTerms Antivenoms
Clinical studies, antivenoms and epidemiology
Naja ashei
Neutralization
Potency
Snakebite
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Title Preclinical efficacy testing of three antivenoms against Naja ashei venom-induced lethality
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