Measurement of NLG207 (formerly CRLX101) nanoparticle-bound and released camptothecin in human plasma - Schmidt, Keith T.; Peer, Cody J.; Huitema, Alwin D.R.; Williams, Monique D.; Wroblewski, Susan; Schellens, Jan H.M.; Madan, Ravi A.; Figg, William D. (Journal of pharmaceutical and biomedical analysis, 2020)
Keywords: Adult; Anti-cancer; Antineoplastic Combined Chemotherapy Protocols - pharmacokinetics; Antineoplastic Combined Chemotherapy Protocols - therapeutic use; Benzamides; Bioanalytical; Camptothecin - blood; Camptothecin - isolation & purification; Camptothecin - pharmacokinetics; Camptothecin - therapeutic use; Clinical pharmacology; Cyclodextrins - blood; Cyclodextrins - isolation & purification; Cyclodextrins - pharmacokinetics; Cyclodextrins - therapeutic use; Drug Interactions; Drug Stability; Humans; Male; Mass spectrometry; Middle Aged; Nitriles; Oncology; Pharmacokinetics; Phenylthiohydantoin - analogs & derivatives; Phenylthiohydantoin - pharmacokinetics; Phenylthiohydantoin - therapeutic use; Prostatic Neoplasms, Castration-Resistant - blood; Prostatic Neoplasms, Castration-Resistant - drug therapy; Topoisomerase I inhibitor; Clinical pharmacology; Oncology; Bioanalytical; Anti-cancer; Pharmacokinetics; Mass spectrometry; Topoisomerase I inhibitor