Recombinant protein vaccines, a proven approach against coronavirus pandemics

• Published in: Advanced drug delivery reviews Vol. 170; pp. 71 - 82
• Main Authors: Pollet, Jeroen, Chen, Wen-Hsiang, Strych, Ulrich
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2021
• Subjects: Adjuvants; Animals; Clinical trials; Clinical Trials as Topic - methods; Coronavirus Infections - epidemiology; Coronavirus Infections - immunology; Coronavirus Infections - prevention & control; COVID-19; COVID-19 - epidemiology; COVID-19 - immunology; COVID-19 - prevention & control; COVID-19 Vaccines - administration & dosage; COVID-19 Vaccines - immunology; Drug Development - methods; Health Resources - trends; Humans; Neutralizing antibodies; Pandemics - prevention & control; Recombinant Proteins - administration & dosage; Recombinant Proteins - immunology; SARS-CoV-2; SARS-CoV-2 - drug effects; SARS-CoV-2 - immunology; Th1; Vaccine delivery; Vaccine production; Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; Viral Vaccines - administration & dosage; Viral Vaccines - immunology; MNA; ADE; FDA; Clinical trials; PTM; cGMP; TMPRSS2; CoV; Vaccine delivery; COVID-19; COVID; S-protein; SARS-CoV-2; HHS; RBD; Th1; RBM; WHO; aa; Neutralizing antibodies; Adjuvants; SARS; OWS; Vaccine production; APC; RSV; ACE-2; Alum; MERS; NTD

With the COVID-19 pandemic now ongoing for close to a year, people all over the world are still waiting for a vaccine to become available. The initial focus of accelerated global research and development efforts to bring a vaccine to market as soon as possible was on novel platform technologies that...