Virally Activated CD8 T Cells Home to Mycobacterium bovis BCG-Induced Granulomas but Enhance Antimycobacterial Protection Only in Immunodeficient Mice

• Published in: Infection and Immunity Vol. 75; no. 3; pp. 1154 - 1166
• Main Authors: Hogan, Laura H, Co, Dominic O, Karman, Jozsef, Heninger, Erika, Suresh, M, Sandor, Matyas
• Format: Journal Article
• Language: English
• Published: Washington, DC American Society for Microbiology 01.03.2007
• Subjects: Animals; Bacterial diseases; Biological and medical sciences; CD8-Positive T-Lymphocytes - cytology; CD8-Positive T-Lymphocytes - immunology; CD8-Positive T-Lymphocytes - virology; Cell Movement - genetics; Cell Movement - immunology; Fundamental and applied biological sciences. Psychology; Granuloma - genetics; Granuloma - immunology; Granuloma - prevention & control; Granuloma - virology; Host Response and Inflammation; Human bacterial diseases; Immunologic Deficiency Syndromes - immunology; Immunologic Deficiency Syndromes - pathology; Immunologic Deficiency Syndromes - virology; Infectious diseases; Lymphocyte Activation - genetics; Lymphocyte Activation - immunology; Lymphocytic choriomeningitis virus; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microbiology; Mycobacterium bovis; Mycobacterium bovis - immunology; Tuberculosis and atypical mycobacterial infections; Microbiology; Mycobacterium bovis; Rodentia; BCG; Mycobacterial infection; Immunity; Infection; Vertebrata; Mammalia; Tuberculosis; Mouse; Mycobacteriales; T-Lymphocyte; Bacteriosis; Mycobacteriaceae; Bacteria; Actinomycetes

The effect of secondary infections on CD4 T-cell-regulated chronic granulomatous inflammation is not well understood. Here, we have investigated the effect of an acute viral infection on the cellular composition and bacterial protection in Mycobacterium bovis strain bacille Calmette-Guérin (BCG)-ind...