Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes

• Published in: Cell metabolism Vol. 27; no. 6; pp. 1212 - 1221.e3
• Main Authors: Sutton, Elizabeth F., Beyl, Robbie, Early, Kate S., Cefalu, William T., Ravussin, Eric, Peterson, Courtney M.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 05.06.2018
• Subjects: Adult; Aged; Blood Pressure; circadian rhythms; circadian system; early time-restricted feeding; eTRF; Fasting - metabolism; Humans; Insulin Resistance; insulin sensitivity; Insulin-Secreting Cells - metabolism; intermittent fasting; Male; meal timing; Middle Aged; Oxidative Stress; prediabetes; Prediabetic State - diet therapy; Prediabetic State - metabolism; Proof of Concept Study; Weight Loss; insulin sensitivity; blood pressure; intermittent fasting; prediabetes; early time-restricted feeding; eTRF; meal timing; circadian rhythms; circadian system; insulin resistance

Intermittent fasting (IF) improves cardiometabolic health; however, it is unknown whether these effects are due solely to weight loss. We conducted the first supervised controlled feeding trial to test whether IF has benefits independent of weight loss by feeding participants enough food to maintain...