Telomere lengths at birth in trisomies 18 and 21 measured by Q-FISH

• Published in: Gene Vol. 533; no. 1; pp. 199 - 207
• Main Authors: Nakamura, Ken-ichi, Ishikawa, Naoshi, Izumiyama, Naotaka, Aida, Junko, Kuroiwa, Mie, Hiraishi, Naoki, Fujiwara, Mutsunori, Nakao, Atsushi, Kawakami, Tadashi, Poon, Steven S.S., Matsuura, Masaaki, Sawabe, Motoji, Arai, Tomio, Takubo, Kaiyo
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.01.2014
• Subjects: alcohol drinking; Calibration; Chromosomes, Human, Pair 18; Diploidy; Down syndrome; Down Syndrome - genetics; genetic disorders; Humans; In Situ Hybridization, Fluorescence - methods; Infant, Newborn; Karyotyping; lifestyle; longevity; lymphocytes; neonates; obesity; patients; Q-FISH; smoking (habit); Telomere; telomeres; trisomics; Trisomy; Trisomy 18; Trisomy 21; TFU; PNA; Q-FISH; Trisomy 18; TRF; DAPI; Down syndrome; Telomere; Telo C; Trisomy 21; kbp; PDL; PBL; CENP1; quantitative fluorescence in situ hybridization; population doubling level; FITC-labeled CTTCGTTGGAAACGGGGT peptide nucleic acid probe; kilobase pairs; terminal restriction fragment; telomere fluorescence unit; peripheral blood lymphocyte; 4′, 6-diamidino-2-phenylindole; Cy3-labeled (CCCTAA)3 peptide nucleic acid probe; peptide nucleic acid

Trisomies 18 and 21 are genetic disorders in which cells possess an extra copy of each of the relevant chromosomes. Individuals with these disorders who survive birth generally have a shortened life expectancy. As telomeres are known to play an important role in the maintenance of genomic integrity...