Quantification of N-(3-chloro-2-hydroxypropyl)valine in human haemoglobin as a biomarker of epichlorohydrin exposure by gas chromatography–tandem mass spectrometry with stable-isotope dilution

• Published in: Journal of chromatography. B, Analytical technologies in the biomedical and life sciences Vol. 877; no. 13; pp. 1402 - 1415
• Main Authors: Bader, Michael, Rosenberger, Wolfgang, Gutzki, Frank-Mathias, Tsikas, Dimitrios
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.05.2009
• Subjects: Acetylation; Biomarkers - chemistry; Biomonitoring; Calibration; Deuterium-labelling; Epichlorohydrin; Epichlorohydrin - toxicity; Gas Chromatography-Mass Spectrometry - methods; GC-tandem MS; Globin; Hemoglobins - chemistry; Humans; Isotopes; Protein adducts; Reference Standards; Reproducibility of Results; Sensitivity and Specificity; Tandem Mass Spectrometry - methods; Globin; Epichlorohydrin; Deuterium-labelling; Biomonitoring; Protein adducts; GC–tandem MS

Epichlorohydrin (ECH) is an important industrial intermediate for the production of polymers and surface coatings. Animal experiments support the classification of ECH as a carcinogen, and a significant contribution to the cancer risk of ECH exposed humans has to be considered. Upon uptake, epichlor...