Activity-based protein profiling in bacteria: Applications for identification of therapeutic targets and characterization of microbial communities
Activity-based protein profiling (ABPP) is a robust chemoproteomic technique that uses activity-based probes to globally measure endogenous enzymatic activity in complex proteomes. It has been utilized extensively to characterize human disease states and identify druggable targets in diverse disease...
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| Published in | Current opinion in chemical biology Vol. 54; pp. 45 - 53 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
England
Elsevier Ltd
01.02.2020
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| Abstract | Activity-based protein profiling (ABPP) is a robust chemoproteomic technique that uses activity-based probes to globally measure endogenous enzymatic activity in complex proteomes. It has been utilized extensively to characterize human disease states and identify druggable targets in diverse disease conditions. ABPP has also recently found applications in microbiology. This includes using activity-based probes (ABPs) for functional studies of pathogenic bacteria as well as complex communities within a microbiome. This review will focus on recent advances in the use of ABPs to profile enzyme activity in disease models, screen for selective inhibitors of key enzymes, and develop imaging tools to better understand the host–bacterial interface. |
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| AbstractList | Activity-based protein profiling (ABPP) is a robust chemoproteomic technique that uses activity-based probes to globally measure endogenous enzymatic activity in complex proteomes. It has been utilized extensively to characterize human disease states and identify druggable targets in diverse disease conditions. ABPP has also recently found applications in microbiology. This includes using activity-based probes (ABPs) for functional studies of pathogenic bacteria as well as complex communities within a microbiome. This review will focus on recent advances in the use of ABPs to profile enzyme activity in disease models, screen for selective inhibitors of key enzymes, and develop imaging tools to better understand the host–bacterial interface. Activity-based protein profiling (ABPP) is a robust chemoproteomic technique that uses activity-based probes to globally measure endogenous enzymatic activity in complex proteomes. It has been utilized extensively to characterize human disease states and identify druggable targets in diverse disease conditions. ABPP has also recently found applications in microbiology. This includes using activity-based probes (ABPs) for functional studies of pathogenic bacteria as well as complex communities within a microbiome. This review will focus on recent advances in the use of ABPs to profile enzyme activity in disease models, screen for selective inhibitors of key enzymes, and develop imaging tools to better understand the host-bacterial interface.Activity-based protein profiling (ABPP) is a robust chemoproteomic technique that uses activity-based probes to globally measure endogenous enzymatic activity in complex proteomes. It has been utilized extensively to characterize human disease states and identify druggable targets in diverse disease conditions. ABPP has also recently found applications in microbiology. This includes using activity-based probes (ABPs) for functional studies of pathogenic bacteria as well as complex communities within a microbiome. This review will focus on recent advances in the use of ABPs to profile enzyme activity in disease models, screen for selective inhibitors of key enzymes, and develop imaging tools to better understand the host-bacterial interface. |
| Author | Bogyo, Matthew Keller, Laura J. Babin, Brett M. Lakemeyer, Markus |
| AuthorAffiliation | 3 Departments of Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA 1 Departments of Chemical & Systems Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA 2 Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA |
| AuthorAffiliation_xml | – name: 1 Departments of Chemical & Systems Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA – name: 2 Departments of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA – name: 3 Departments of Microbiology and Immunology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA 94305, USA |
| Author_xml | – sequence: 1 givenname: Laura J. surname: Keller fullname: Keller, Laura J. organization: Department of Chemical & Systems Biology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA – sequence: 2 givenname: Brett M. orcidid: 0000-0002-4133-6665 surname: Babin fullname: Babin, Brett M. organization: Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA – sequence: 3 givenname: Markus orcidid: 0000-0001-6580-3275 surname: Lakemeyer fullname: Lakemeyer, Markus organization: Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA – sequence: 4 givenname: Matthew orcidid: 0000-0003-3753-4412 surname: Bogyo fullname: Bogyo, Matthew email: mbogyo@stanford.edu organization: Department of Pathology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA |
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| Keywords | Bacteria Activity-based protein profiling Microbiome |
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| SubjectTerms | Activity-based protein profiling Animals Bacteria Bacteria - chemistry Bacteria - enzymology Bacteria - metabolism Bacterial Infections - microbiology Bacterial Proteins - chemistry Bacterial Proteins - metabolism Chromatography, Liquid Enzymes - chemistry Enzymes - metabolism Humans Microbiome Microbiota Protein Array Analysis - methods Proteomics - methods Tandem Mass Spectrometry |
| Title | Activity-based protein profiling in bacteria: Applications for identification of therapeutic targets and characterization of microbial communities |
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