Free energy calculations shed light on the nuclear pore complex’s selective barrier nature

• Published in: Biophysical journal Vol. 120; no. 17; pp. 3628 - 3640
• Main Authors: Matsuda, Atsushi, Mofrad, Mohammad R.K.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 07.09.2021; Elsevier; The Biophysical Society
• Subjects: BASIC BIOLOGICAL SCIENCES

The nuclear pore complex (NPC) is the exclusive gateway for traffic control across the nuclear envelope. Although smaller cargoes (less than 5–9 nm in size) can freely diffuse through the NPC, the passage of larger cargoes is restricted to those accompanied by nuclear transport receptors (NTRs). Thi...