The Small Intestine Converts Dietary Fructose into Glucose and Organic Acids

• Published in: Cell metabolism Vol. 27; no. 2; pp. 351 - 361.e3
• Main Authors: Jang, Cholsoon, Hui, Sheng, Lu, Wenyun, Cowan, Alexis J., Morscher, Raphael J., Lee, Gina, Liu, Wei, Tesz, Gregory J., Birnbaum, Morris J., Rabinowitz, Joshua D.
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 06.02.2018
• Subjects: Animals; Carboxylic Acids - metabolism; Dietary Carbohydrates - metabolism; Feeding Behavior; flux; fructose; Fructose - metabolism; Glucose - metabolism; gut; Intestine, Small - metabolism; Isotope Labeling; isotope tracing; Liver - metabolism; metabolic disease; Metabolome; metabolomics; Mice, Inbred C57BL; microbiome; Microbiota; Models, Biological; small intestine; sucrose; sugar; metabolomics; isotope tracing; gut; fructose; flux; small intestine; sucrose; metabolic disease; microbiome; sugar

Excessive consumption of sweets is a risk factor for metabolic syndrome. A major chemical feature of sweets is fructose. Despite strong ties between fructose and disease, the metabolic fate of fructose in mammals remains incompletely understood. Here we use isotope tracing and mass spectrometry to t...