Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode
[Display omitted]
Saved in:
| Published in | Science bulletin (Beijing) Vol. 66; no. 7; pp. 661 - 663 |
|---|---|
| Main Authors | , , , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Netherlands
Elsevier B.V
15.04.2021
Science China Press. Published by Elsevier B.V. and Science China Press |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | [Display omitted] |
|---|---|
| AbstractList | [Display omitted] |
| Author | McCormick, Peter J. Wang, Qisheng Zhong, Fanglin Jiang, Feng Duan, Jingjing Fu, Yang Luo, Jun Zhang, Jin Zhou, Huan Zhou, Xuelan Lin, Cheng Zhang, Yan Li, Jian |
| Author_xml | – sequence: 1 givenname: Jian surname: Li fullname: Li, Jian email: rmsl_2040@163.com organization: College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, China – sequence: 2 givenname: Xuelan surname: Zhou fullname: Zhou, Xuelan organization: School of Basic Medical Sciences, Nanchang University, Nanchang 330031, China – sequence: 3 givenname: Yan surname: Zhang fullname: Zhang, Yan organization: The Second Affiliated Hospital of Nanchang University, Nanchang 330031, China – sequence: 4 givenname: Fanglin surname: Zhong fullname: Zhong, Fanglin organization: Shenzhen Crystalo Biopharmaceutical Co., Ltd, Shenzhen 518118, China – sequence: 5 givenname: Cheng surname: Lin fullname: Lin, Cheng organization: Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases, Ministry of Education, Gannan Medical University, Ganzhou 341000, China – sequence: 6 givenname: Peter J. surname: McCormick fullname: McCormick, Peter J. organization: William Harvey Research Institute, Bart’s and the London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK – sequence: 7 givenname: Feng surname: Jiang fullname: Jiang, Feng organization: College of Pharmaceutical Sciences, Gannan Medical University, Ganzhou 341000, China – sequence: 8 givenname: Jun surname: Luo fullname: Luo, Jun organization: The Second Affiliated Hospital of Nanchang University, Nanchang 330031, China – sequence: 9 givenname: Huan surname: Zhou fullname: Zhou, Huan organization: Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China – sequence: 10 givenname: Qisheng surname: Wang fullname: Wang, Qisheng organization: Shanghai Synchrotron Radiation Facility, Shanghai Advanced Research Institute, Chinese Academy of Sciences, Shanghai 201204, China – sequence: 11 givenname: Yang surname: Fu fullname: Fu, Yang organization: School of Medicine, Southern University of Science and Technology, Shenzhen 518055, China – sequence: 12 givenname: Jingjing surname: Duan fullname: Duan, Jingjing organization: Human Aging Research Institute (HARI), School of Life Sciences, Nanchang University, Nanchang 330031, China – sequence: 13 givenname: Jin surname: Zhang fullname: Zhang, Jin email: zhangxiaokong@hotmail.com organization: School of Basic Medical Sciences, Nanchang University, Nanchang 330031, China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33163253$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kc1u1TAQhSNUREvpC7BAXrLJxT9x4kgIqbriT6qERCu2luNMmrkk9sV2Cn0BnhtHt62ARVcejb9zxp7zvDhy3kFRvGR0wyir3-w20WK34ZSvjQ1l6klxwmkry5YrdvRQN-K4OItxRyllVcsr2jwrjoVgteBSnBS_t-E2JjORmMJi0xKA-IFcnn-9LLf-W8nJbNCRffAJTASSa-vn_QS_yE9MI0kjEGeyLDtkqM8WmRmxw-QDiSN-9y5rcJqWGTMIkRiyOPyxAOnQ9eiuyex7eFE8HcwU4ezuPC2uPry_2n4qL758_Lw9vyhtJWUqRScr1lGpeqZqLhpmuISe9l0DwyD6yooaaG2YhY6ptqmgMkrJpuIdb7ji4rR4d7DdL90MvQWX8sv1PuBswq32BvW_Nw5Hfe1vdCNbpdo2G7y-Mwg-_yEmPWO0ME3GgV-i5pVUbS2rmmX01d-zHobc7z4D6gDY4GMMMGiLyST062icNKN6TVrv9Jq0XpNeeznpLOX_Se_dHxW9PYggL_gGIawIOAs9BrBJ9x4fk_8BUKzEWA |
| CitedBy_id | crossref_primary_10_1016_j_apsb_2023_08_004 crossref_primary_10_1016_j_jmb_2024_168474 crossref_primary_10_3390_biom13091339 crossref_primary_10_1016_j_phymed_2023_154943 crossref_primary_10_3390_ph17050656 crossref_primary_10_3390_ijms24043100 crossref_primary_10_1016_j_bbrc_2024_150231 crossref_primary_10_1038_s41579_021_00630_8 crossref_primary_10_1016_j_bbrc_2024_150230 crossref_primary_10_1021_acsomega_2c05766 crossref_primary_10_3390_ph16050767 crossref_primary_10_3389_fmars_2023_1028319 crossref_primary_10_1021_acs_jmedchem_1c00509 crossref_primary_10_1128_jvi_02013_21 crossref_primary_10_3390_v16010065 crossref_primary_10_1016_j_str_2023_06_010 crossref_primary_10_1016_j_csbj_2021_08_036 crossref_primary_10_1038_s42003_025_07929_9 crossref_primary_10_1016_j_jmb_2022_167706 crossref_primary_10_1080_14756366_2024_2301772 crossref_primary_10_2174_0929867330666230321103731 crossref_primary_10_1002_mco2_151 crossref_primary_10_1016_j_ejmech_2022_114314 crossref_primary_10_1016_j_jmb_2024_168784 crossref_primary_10_3724_abbs_2024122 crossref_primary_10_3724_abbs_2023053 crossref_primary_10_1016_j_ejmech_2022_114572 crossref_primary_10_2217_fvl_2022_0163 crossref_primary_10_3390_v14092075 crossref_primary_10_1016_j_bbrc_2022_04_086 crossref_primary_10_1360_SSV_2021_0394 crossref_primary_10_1128_JVI_01253_21 crossref_primary_10_1016_j_csbj_2021_08_029 crossref_primary_10_1080_0889311X_2023_2222275 crossref_primary_10_1038_s41467_021_20900_6 crossref_primary_10_1016_j_bbrc_2024_150469 crossref_primary_10_1016_j_ejmech_2023_116000 crossref_primary_10_2174_1570180820666230502152058 crossref_primary_10_1016_j_bbrc_2023_03_043 crossref_primary_10_1016_j_apsb_2021_10_026 crossref_primary_10_1016_j_ejmech_2023_115772 crossref_primary_10_1016_j_phytochem_2024_114368 crossref_primary_10_1107_S2059798322011901 crossref_primary_10_3390_molecules28020514 crossref_primary_10_3390_biom11040607 crossref_primary_10_3390_molecules30061321 |
| Cites_doi | 10.1056/NEJMoa2001316 10.1126/science.abb3405 10.1126/science.abb4489 10.3390/v11020197 10.1056/NEJMoa2001017 10.1038/s41586-020-2223-y 10.1038/s41594-020-0440-6 10.1021/acs.jmedchem.9b01828 |
| ContentType | Journal Article |
| Copyright | 2020 Science China Press 2020 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. 2020 Science China Press |
| Copyright_xml | – notice: 2020 Science China Press – notice: 2020 Science China Press. Published by Elsevier B.V. and Science China Press. All rights reserved. 2020 Science China Press |
| DBID | AAYXX CITATION NPM 7X8 5PM |
| DOI | 10.1016/j.scib.2020.10.018 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) |
| EISSN | 2095-9281 |
| EndPage | 663 |
| ExternalDocumentID | PMC7598899 33163253 10_1016_j_scib_2020_10_018 S2095927320306885 |
| Genre | Journal Article |
| GroupedDBID | --M 0R~ 4.4 5VR AACTN AAEDT AAEDW AAIAV AAJKR AAKOC AALRI AAOAW AARTL AAXUO AAYIU ABBBX ABJNI ABMAC ABQEM ABQYD ABTHY ABUDA ABYKQ ACDAQ ACGFS ACIWK ACKNC ACPRK ACRLP ADBBV ADINQ AEBSH AEGNC AEHWI AEJHL AENEX AFKWA AFRAH AFTJW AFXIZ AFZHZ AFZKB AGUBO AGWZB AGYKE AHBYD AHJVU AIEXJ AIIXL AIKHN AITUG AJSZI ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ASPBG ATOGT AUKKA AVWKF AXJTR AZFZN BGNMA BJAXD BKOJK CCEZO CCVFK CHBEP EBS EFJIC EFLBG FA0 FDB FIRID FRRFC FYGXN IXD KOM KOV M41 M4Y NU0 O9- ROL RSV SOJ SPC SPCBC SSE SSK SST SSU SSZ T5K ~G- -SA -S~ 5XA 5XB AAIAL AANXM AAQFI AATTM AAXKI AAYQN AAYTO AAYWO AAYXX AAYZH ABFSG ABJOX ABTEG ABTMW ACBXY ACSTC ACVFH ADCNI ADKPE ADRFC ADVLN AEIPS AEOHA AEPYU AEUPX AEZWR AFBBN AFHIU AFJKZ AFLOW AFPUW AFUIB AGCQF AGJBK AGQMX AGRNS AHAVH AHSBF AHWEU AIGII AIIUN AIXLP AJBLW AKBMS AKRWK AKYEP AMKLP ANKPU APXCP BNPGV CAJEA CITATION CJPJV CSCUP EJD H13 HX~ Q-- SSH TCJ TGP U1G U5K UG4 NPM 7X8 5PM EFKBS |
| ID | FETCH-LOGICAL-c455t-3b541b058d1862371a25ed0db7eff3d4c36e06a1ceb18974e4a885742b272823 |
| IEDL.DBID | AIKHN |
| ISSN | 2095-9273 |
| IngestDate | Thu Aug 21 14:08:55 EDT 2025 Thu Jul 10 23:15:52 EDT 2025 Thu Apr 03 06:53:57 EDT 2025 Thu Apr 24 23:03:46 EDT 2025 Tue Jul 01 02:08:24 EDT 2025 Fri Feb 23 02:46:40 EST 2024 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 7 |
| Language | English |
| License | https://www.elsevier.com/tdm/userlicense/1.0 Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c455t-3b541b058d1862371a25ed0db7eff3d4c36e06a1ceb18974e4a885742b272823 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors contributed equally to this work. |
| OpenAccessLink | https://pubmed.ncbi.nlm.nih.gov/PMC7598899 |
| PMID | 33163253 |
| PQID | 2458965461 |
| PQPubID | 23479 |
| PageCount | 3 |
| ParticipantIDs | pubmedcentral_primary_oai_pubmedcentral_nih_gov_7598899 proquest_miscellaneous_2458965461 pubmed_primary_33163253 crossref_citationtrail_10_1016_j_scib_2020_10_018 crossref_primary_10_1016_j_scib_2020_10_018 elsevier_sciencedirect_doi_10_1016_j_scib_2020_10_018 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2021-04-15 |
| PublicationDateYYYYMMDD | 2021-04-15 |
| PublicationDate_xml | – month: 04 year: 2021 text: 2021-04-15 day: 15 |
| PublicationDecade | 2020 |
| PublicationPlace | Netherlands |
| PublicationPlace_xml | – name: Netherlands |
| PublicationTitle | Science bulletin (Beijing) |
| PublicationTitleAlternate | Sci Bull (Beijing) |
| PublicationYear | 2021 |
| Publisher | Elsevier B.V Science China Press. Published by Elsevier B.V. and Science China Press |
| Publisher_xml | – name: Elsevier B.V – name: Science China Press. Published by Elsevier B.V. and Science China Press |
| References | Li, Guan, Wu (b0005) 2020; 382 Zhang, Lin, Sun (b0045) 2020; 368 Jin, Zhao, Sun (b0040) 2020; 27 Zhu, Zhang, Wang (b0010) 2020; 382 Su, Yao, Zhao (b0050) 2020 Jin, Du, Xu (b0035) 2020; 582 Zhou, Zhong, Lin (b0025) 2020 Chang, Kim, Lovell (b0020) 2019; 11 Zhang, Lin, Kusov (b0015) 2020; 63 Dai, Zhang, Jiang (b0030) 2020; 368 Jin (10.1016/j.scib.2020.10.018_b0035) 2020; 582 Zhu (10.1016/j.scib.2020.10.018_b0010) 2020; 382 Jin (10.1016/j.scib.2020.10.018_b0040) 2020; 27 Chang (10.1016/j.scib.2020.10.018_b0020) 2019; 11 Zhang (10.1016/j.scib.2020.10.018_b0045) 2020; 368 Su (10.1016/j.scib.2020.10.018_b0050) 2020 Zhang (10.1016/j.scib.2020.10.018_b0015) 2020; 63 Li (10.1016/j.scib.2020.10.018_b0005) 2020; 382 Dai (10.1016/j.scib.2020.10.018_b0030) 2020; 368 Zhou (10.1016/j.scib.2020.10.018_b0025) 2020 |
| References_xml | – volume: 63 start-page: 4562 year: 2020 end-page: 4578 ident: b0015 article-title: α-Ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication: structure-based design, synthesis, and activity assessment publication-title: J Med Chem – volume: 368 start-page: 1331 year: 2020 end-page: 1335 ident: b0030 article-title: Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease publication-title: Science – volume: 11 start-page: 197 year: 2019 ident: b0020 article-title: Antiviral drug discovery: norovirus proteases and development of inhibitors publication-title: Viruses – year: 2020 ident: b0050 article-title: Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease publication-title: bioRxiv – volume: 382 start-page: 727 year: 2020 end-page: 733 ident: b0010 article-title: A novel coronavirus from patients with pneumonia in China, 2019 publication-title: N Engl J Med – volume: 27 start-page: 529 year: 2020 end-page: 532 ident: b0040 article-title: Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur publication-title: Nat Struct Mol Biol – year: 2020 ident: b0025 article-title: Structure of SARS-CoV-2 main protease in the apo state publication-title: Sci China Life Sci – volume: 382 start-page: 1199 year: 2020 end-page: 1207 ident: b0005 article-title: Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia publication-title: N Engl J Med – volume: 368 start-page: 409 year: 2020 end-page: 412 ident: b0045 article-title: Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors publication-title: Science – volume: 582 start-page: 289 year: 2020 end-page: 293 ident: b0035 article-title: Structure of M publication-title: Nature – volume: 382 start-page: 1199 year: 2020 ident: 10.1016/j.scib.2020.10.018_b0005 article-title: Early transmission dynamics in Wuhan, China, of novel coronavirus–infected pneumonia publication-title: N Engl J Med doi: 10.1056/NEJMoa2001316 – year: 2020 ident: 10.1016/j.scib.2020.10.018_b0025 article-title: Structure of SARS-CoV-2 main protease in the apo state publication-title: Sci China Life Sci – volume: 368 start-page: 409 year: 2020 ident: 10.1016/j.scib.2020.10.018_b0045 article-title: Crystal structure of SARS-CoV-2 main protease provides a basis for design of improved α-ketoamide inhibitors publication-title: Science doi: 10.1126/science.abb3405 – volume: 368 start-page: 1331 year: 2020 ident: 10.1016/j.scib.2020.10.018_b0030 article-title: Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease publication-title: Science doi: 10.1126/science.abb4489 – volume: 11 start-page: 197 year: 2019 ident: 10.1016/j.scib.2020.10.018_b0020 article-title: Antiviral drug discovery: norovirus proteases and development of inhibitors publication-title: Viruses doi: 10.3390/v11020197 – volume: 382 start-page: 727 year: 2020 ident: 10.1016/j.scib.2020.10.018_b0010 article-title: A novel coronavirus from patients with pneumonia in China, 2019 publication-title: N Engl J Med doi: 10.1056/NEJMoa2001017 – volume: 582 start-page: 289 year: 2020 ident: 10.1016/j.scib.2020.10.018_b0035 article-title: Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors publication-title: Nature doi: 10.1038/s41586-020-2223-y – volume: 27 start-page: 529 year: 2020 ident: 10.1016/j.scib.2020.10.018_b0040 article-title: Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur publication-title: Nat Struct Mol Biol doi: 10.1038/s41594-020-0440-6 – volume: 63 start-page: 4562 year: 2020 ident: 10.1016/j.scib.2020.10.018_b0015 article-title: α-Ketoamides as broad-spectrum inhibitors of coronavirus and enterovirus replication: structure-based design, synthesis, and activity assessment publication-title: J Med Chem doi: 10.1021/acs.jmedchem.9b01828 – year: 2020 ident: 10.1016/j.scib.2020.10.018_b0050 article-title: Discovery of baicalin and baicalein as novel, natural product inhibitors of SARS-CoV-2 3CL protease in vitro publication-title: bioRxiv |
| SSID | ssj0001492407 ssib060475419 ssib054405809 |
| Score | 2.5139916 |
| Snippet | [Display omitted] |
| SourceID | pubmedcentral proquest pubmed crossref elsevier |
| SourceType | Open Access Repository Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 661 |
| SubjectTerms | Short Communication |
| Title | Crystal structure of SARS-CoV-2 main protease in complex with the natural product inhibitor shikonin illuminates a unique binding mode |
| URI | https://dx.doi.org/10.1016/j.scib.2020.10.018 https://www.ncbi.nlm.nih.gov/pubmed/33163253 https://www.proquest.com/docview/2458965461 https://pubmed.ncbi.nlm.nih.gov/PMC7598899 |
| Volume | 66 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1bb9MwFLbG9sILYuNWLpOReACh0MTHTpzHKtpUbhNaB9pbZKeOahhp1a4S_AF-N-ckTrcC2gNvlWtHVs7F33HO-Q5jLwSAsaDrKAcVR1JLtDmoTBQj1MhQw2qlqXb440k6_izfnavzHVb0tTCUVhl8f-fTW28dRobhbQ4X3g8ngq6w8PQVBHu1VrfYnoA8RdXeG719Pz65umqROcUt1GYups6EuCaUz3SZXvh0i5GioIE3MbX_-PcR9TcE_TOT8trRdHyX3QmYko-6be-zHdccsP1gtSv-MlBLv7rHfhXLnwgHL3hHG7teOj6v-WR0OomK-ZdI8O_GN7zlbsDTjePvNuXc_eB0X8sRLPKWCRSfsOioYnHOzFt0C0u-mvlvdLnLPXVP9g2hWG74uqWI5da39TOcWu_cZ2fHR2fFOAqdGKJKKnUZgVUysbHS0wQjIMgSI5SbxkTNXNcwlRWkLk5NUqHn1xihOGlQIBh1W5FhTAcP2G4zb9wjxmVtNaIMBJIOsRCkOViAKjUafa6up27Akv7dl1VgKadmGRdln472tSR5lSQvGkN5DdjrzZpFx9Fx42zVi7Tc0rQSD5Eb1z3v5V-iCdJ3FdO4-XpVCql0TkVhyYA97PRhsw8ABLxCwYBlW5qymUD03tv_NH7W0nxnKtcYDT_-z_0-YbcF5d8QL6V6ynZRr9wzBFCX9hANpDj98OkwGMpvh2AbHg |
| linkProvider | Elsevier |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1Lb9NAEB6V9AAX1PJqWgqLxAGETOx92OtjFLVKaZsDCai3lddZK4biREkjlT_A72bGXgcCqAdu0WbXWnlmZ75Zz3wD8JoLkVmhiyAVKgyklnjmRJ4FIUKNBDWsUJpqhy9H8fCT_HClrnZg0NbCUFqlt_2NTa-ttR_p-bfZW5Rlb8zpCgu9LyfYq7W6B7vETqU6sNs_Ox-Ofl21yJTiFmozF1JnQlzjy2eaTC98usVIkdPA-5Daf_zbRf0NQf_MpPzNNZ3uwUOPKVm_2fY-7LjqEez7U7tibzy19NvH8GOw_I5w8Jo1tLHrpWPzgo37H8fBYP454OxbVlas5m5A78bwd51y7m4Z3dcyBIusZgLFJywaqlicMystmoUlW83Kr3S5y0rqnlxWhGJZxtY1RSyzZV0_w6j1zhOYnJ5MBsPAd2IIcqnUTSCskpENlZ5GGAGJJMq4ctOQqJmLQkxlLmIXxlmUo-XXGKE4maFAMOq2PMGYTjyFTjWv3AEwWViNKAOBpEMsJOJUWCHyONNoc3UxdV2I2ndvcs9STs0yrk2bjvbFkLwMyYvGUF5deLdZs2g4Ou6crVqRmi1NM-hE7lz3qpW_wSNI31Wyys3XK8Ol0ikVhUVdeNbow2YfQiDg5Up0IdnSlM0Eovfe_qcqZzXNd6JSjdHw4X_u9yXcH04uL8zF2ej8CB5wysUhjkr1HDqoY-4YwdSNfeEPy0_7Ihxv |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Crystal+structure+of+SARS-CoV-2+main+protease+in+complex+with+the+natural+product+inhibitor+shikonin+illuminates+a+unique+binding+mode&rft.jtitle=Science+bulletin+%28Beijing%29&rft.au=Li%2C+Jian&rft.au=Zhou%2C+Xuelan&rft.au=Zhang%2C+Yan&rft.au=Zhong%2C+Fanglin&rft.date=2021-04-15&rft.pub=Science+China+Press.+Published+by+Elsevier+B.V.+and+Science+China+Press&rft.issn=2095-9273&rft.eissn=2095-9281&rft.volume=66&rft.issue=7&rft.spage=661&rft.epage=663&rft_id=info:doi/10.1016%2Fj.scib.2020.10.018&rft_id=info%3Apmid%2F33163253&rft.externalDocID=PMC7598899 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=2095-9273&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=2095-9273&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=2095-9273&client=summon |