Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study
Abstract Objective Preclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand (HOA), but evidence from observational studies remains scarce. We aimed to analyse the association between hyperlipidaemia and incident HOA. Desig...
Saved in:
Published in | Osteoarthritis and cartilage Vol. 25; no. 7; pp. 1040 - 1045 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.07.2017
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Abstract | Abstract Objective Preclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand (HOA), but evidence from observational studies remains scarce. We aimed to analyse the association between hyperlipidaemia and incident HOA. Design We conducted a matched (1:1) case-control study using the UK-based Clinical Practice Research Datalink. Cases were patients aged 30 to 89 years with an incident diagnosis of HOA between 1995 and 2014. In multivariable conditional logistic regression analyses, we calculated odds ratios (OR) for incident HOA in patients with hyperlipidaemia, categorized by gender, age, previous duration of hyperlipidaemia, and recent statin treatment. Results Among 19,590 cases and 19,590 controls, we observed an increased risk of HOA in patients with hyperlipidaemia (OR 1.37, 95% CI 1.28-1.47), when compared to patients without hyperlipidaemia. Thus, of all HOA cases in our study population, 3.6% may have been attributable to the presence of hyperlipidaemia (population attributable risk). Most patients with HOA were elderly, but the strength of the association between HOA and hyperlipidaemia inversely correlated with increasing age, with the highest OR of 1.72 (95% CI 1.24-2.38) in patients aged 29-49 years. Categorization by previous hyperlipidaemia duration, as well as sub-classification of patients with hyperlipidaemia into those with and without recent statin use did not meaningfully change the effect estimate. Conclusions Our results suggest that hyperlipidaemia may be an independent risk factor for new onset HOA. |
---|---|
AbstractList | Abstract Objective Preclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand (HOA), but evidence from observational studies remains scarce. We aimed to analyse the association between hyperlipidaemia and incident HOA. Design We conducted a matched (1:1) case-control study using the UK-based Clinical Practice Research Datalink. Cases were patients aged 30 to 89 years with an incident diagnosis of HOA between 1995 and 2014. In multivariable conditional logistic regression analyses, we calculated odds ratios (OR) for incident HOA in patients with hyperlipidaemia, categorized by gender, age, previous duration of hyperlipidaemia, and recent statin treatment. Results Among 19,590 cases and 19,590 controls, we observed an increased risk of HOA in patients with hyperlipidaemia (OR 1.37, 95% CI 1.28-1.47), when compared to patients without hyperlipidaemia. Thus, of all HOA cases in our study population, 3.6% may have been attributable to the presence of hyperlipidaemia (population attributable risk). Most patients with HOA were elderly, but the strength of the association between HOA and hyperlipidaemia inversely correlated with increasing age, with the highest OR of 1.72 (95% CI 1.24-2.38) in patients aged 29-49 years. Categorization by previous hyperlipidaemia duration, as well as sub-classification of patients with hyperlipidaemia into those with and without recent statin use did not meaningfully change the effect estimate. Conclusions Our results suggest that hyperlipidaemia may be an independent risk factor for new onset HOA. Preclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand (HOA), but evidence from observational studies remains scarce. We aimed to analyse the association between hyperlipidaemia and incident HOA. We conducted a matched (1:1) case-control study using the UK-based Clinical Practice Research Datalink (CPRD). Cases were patients aged 30-89 years with an incident diagnosis of HOA between 1995 and 2014. In multivariable conditional logistic regression analyses, we calculated odds ratios (OR) for incident HOA in patients with hyperlipidaemia, categorized by gender, age, previous duration of hyperlipidaemia, and recent statin treatment. Among 19,590 cases and 19,590 controls, we observed an increased risk of HOA in patients with hyperlipidaemia (OR 1.37, 95% confidence intervals (CI) 1.28-1.47), when compared to patients without hyperlipidaemia. Thus, of all HOA cases in our study population, 3.6% may have been attributable to the presence of hyperlipidaemia (population attributable risk). Most patients with HOA were elderly, but the strength of the association between HOA and hyperlipidaemia inversely correlated with increasing age, with the highest OR of 1.72 (95% CI 1.24-2.38) in patients aged 29-49 years. Categorization by previous hyperlipidaemia duration, as well as sub-classification of patients with hyperlipidaemia into those with and without recent statin use did not meaningfully change the effect estimate. Our results suggest that hyperlipidaemia may be an independent risk factor for new onset HOA. OBJECTIVEPreclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand (HOA), but evidence from observational studies remains scarce. We aimed to analyse the association between hyperlipidaemia and incident HOA.DESIGNWe conducted a matched (1:1) case-control study using the UK-based Clinical Practice Research Datalink (CPRD). Cases were patients aged 30-89 years with an incident diagnosis of HOA between 1995 and 2014. In multivariable conditional logistic regression analyses, we calculated odds ratios (OR) for incident HOA in patients with hyperlipidaemia, categorized by gender, age, previous duration of hyperlipidaemia, and recent statin treatment.RESULTSAmong 19,590 cases and 19,590 controls, we observed an increased risk of HOA in patients with hyperlipidaemia (OR 1.37, 95% confidence intervals (CI) 1.28-1.47), when compared to patients without hyperlipidaemia. Thus, of all HOA cases in our study population, 3.6% may have been attributable to the presence of hyperlipidaemia (population attributable risk). Most patients with HOA were elderly, but the strength of the association between HOA and hyperlipidaemia inversely correlated with increasing age, with the highest OR of 1.72 (95% CI 1.24-2.38) in patients aged 29-49 years. Categorization by previous hyperlipidaemia duration, as well as sub-classification of patients with hyperlipidaemia into those with and without recent statin use did not meaningfully change the effect estimate.CONCLUSIONSOur results suggest that hyperlipidaemia may be an independent risk factor for new onset HOA. |
Author | Huegle, Thomas, MD, PhD Meier, Christoph R., PhD, MSc Spoendlin, Julia, PhD Frey, Noel, MSc Jick, Susan S., DSc |
Author_xml | – sequence: 1 fullname: Frey, Noel, MSc – sequence: 2 fullname: Huegle, Thomas, MD, PhD – sequence: 3 fullname: Jick, Susan S., DSc – sequence: 4 fullname: Meier, Christoph R., PhD, MSc – sequence: 5 fullname: Spoendlin, Julia, PhD |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28189828$$D View this record in MEDLINE/PubMed |
BookMark | eNp9kUuLFDEURoOMOA_9Ay4kSzfV3rzqISLIoI4w4ELdGlLJLTptdVImKaH_vSl6dOFCuCRZnO-DnHtNLkIMSMhzBjsGrH112B2iNTsOrNsBqyMfkSumOG-GVomL-oZWNFL18pJc53wAAMEYPCGXvGf90PP-iny_Oy2YZr94Z_DoDTXBUR-sdxgKjblgNKnsky8-0zjRske6r8xraugSl3U2xcfQjCajo7aejY2hpDjTXFZ3ekoeT2bO-OzhviHfPrz_envX3H_--On23X1jpVKlEQPrhUKByo5CMGscw65F3kErzTCZCYQCOQ4SwfCJy3bqJpj61o04OKNA3JCX594lxZ8r5qKPPlucZxMwrlmzvu2GXsEgKsrPqE0x54STXpI_mnTSDPTmVR_05lVvXjWwOrKGXjz0r-MR3d_IH5EVeHMGsP7yl8eks_UYLDqf0Bbtov9__9t_4nb2wVsz_8AT5kNcU6j-NNOZa9Bfts1ui2WdAJCqFb8BgUig4g |
CitedBy_id | crossref_primary_10_1186_s12891_017_1809_5 crossref_primary_10_1016_j_joca_2020_04_007 crossref_primary_10_1093_rheumatology_keac359 crossref_primary_10_1002_jor_25440 crossref_primary_10_3390_life13030730 crossref_primary_10_1016_j_monrhu_2021_01_007 crossref_primary_10_1016_j_arr_2020_101249 crossref_primary_10_1038_s41598_017_03317_4 crossref_primary_10_1155_2024_6822664 crossref_primary_10_1155_2018_7561209 crossref_primary_10_1093_abbs_gmab021 crossref_primary_10_3389_fmed_2020_00392 crossref_primary_10_3899_jrheum_210189 crossref_primary_10_1186_s13075_019_2081_x crossref_primary_10_1177_19476035241247700 crossref_primary_10_1080_03009742_2018_1459831 crossref_primary_10_1097_BRS_0000000000004485 crossref_primary_10_1016_j_joca_2021_07_005 crossref_primary_10_1097_BOR_0000000000000463 crossref_primary_10_1155_2020_3105248 crossref_primary_10_7759_cureus_15999 crossref_primary_10_1186_s13018_022_03290_3 crossref_primary_10_1016_j_jot_2020_09_006 crossref_primary_10_1016_j_bone_2021_116076 crossref_primary_10_1002_art_40684 crossref_primary_10_1007_s12016_022_08941_1 crossref_primary_10_1016_j_maturitas_2021_07_006 crossref_primary_10_3899_jrheum_191075 crossref_primary_10_3389_fphar_2022_791376 crossref_primary_10_36740_WLek202011125 crossref_primary_10_2147_IJGM_S325561 crossref_primary_10_1097_BOR_0000000000000479 crossref_primary_10_3389_fphar_2022_1003370 |
Cites_doi | 10.1136/ard.2008.106930 10.1097/gme.0b013e3182745993 10.3109/03009742.2012.656699 10.1136/ard.2005.045724 10.1016/j.maturitas.2015.09.007 10.1016/j.joca.2015.01.002 10.1093/ije/dyv098 10.1097/RHU.0b013e31827cd578 10.1136/annrheumdis-2011-201178 10.1016/j.joca.2016.04.005 10.1089/met.2009.0110 |
ContentType | Journal Article |
Copyright | Osteoarthritis Research Society International 2017 Osteoarthritis Research Society International Copyright © 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
Copyright_xml | – notice: Osteoarthritis Research Society International – notice: 2017 Osteoarthritis Research Society International – notice: Copyright © 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
DBID | 6I. AAFTH CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
DOI | 10.1016/j.joca.2017.01.014 |
DatabaseName | ScienceDirect Open Access Titles Elsevier:ScienceDirect:Open Access Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed CrossRef MEDLINE - Academic |
DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) CrossRef MEDLINE - Academic |
DatabaseTitleList | MEDLINE MEDLINE - Academic |
Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database |
DeliveryMethod | fulltext_linktorsrc |
Discipline | Medicine |
EISSN | 1522-9653 |
EndPage | 1045 |
ExternalDocumentID | 10_1016_j_joca_2017_01_014 28189828 S1063458417300456 1_s2_0_S1063458417300456 |
Genre | Journal Article Observational Study |
GroupedDBID | --- --K --M .1- .FO .~1 0R~ 123 1B1 1P~ 1RT 1~. 1~5 4.4 457 4G. 53G 5RE 5VS 7-5 71M 8P~ 9JM AABNK AACTN AAEDT AAIAV AAIKJ AAKOC AALMO AALRI AAOAW AAQFI AAQXK AAWTL AAXUO ABBQC ABFNM ABLVK ABMAC ABMZM ABPIF ABVKL ABXDB ABYKQ ACDAQ ACGFS ACRLP ADBBV ADEZE AEBSH AEKER AENEX AEVXI AFCTW AFKWA AFRHN AFTJW AFXIZ AGHFR AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY AJUYK ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV CAG COF CS3 DU5 EBS EFJIC EJD EO8 EO9 EP2 EP3 FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HEE HMK HMO HZ~ IHE IPNFZ IXB J1W KOM LCYCR M27 M31 M41 MO0 N9A NCXOZ O-L O9- OAUVE OI0 OK1 OV- OZT P-8 P-9 P2P PC. Q38 R2- RIG ROL RPZ SAE SCC SDF SDG SEL SES SEW SPCBC SSH SSZ T5K WUQ Z5R ~G- 6I. AAEDW AAFTH ABJNI ADMUD EFLBG HVGLF 0SF AAXKI ADVLN AFJKZ AKRWK CGR CUY CVF ECM EIF NPM AAYXX CITATION 7X8 |
ID | FETCH-LOGICAL-c455t-391835e3e5cb331cad1e76e27064a9faf03504b94e0a2f246f7f0f86dbe9da503 |
IEDL.DBID | IXB |
ISSN | 1063-4584 |
IngestDate | Wed Sep 04 03:19:36 EDT 2024 Thu Sep 26 15:43:37 EDT 2024 Sat Sep 28 08:50:44 EDT 2024 Fri Feb 23 02:24:38 EST 2024 Fri Dec 16 06:12:04 EST 2022 |
IsDoiOpenAccess | true |
IsOpenAccess | true |
IsPeerReviewed | true |
IsScholarly | true |
Issue | 7 |
Keywords | observational hand osteoarthritis clinical practice research datalink case-control hyperlipidaemia Hyperlipidaemia Clinical practice research datalink Observational Hand osteoarthritis Case-control |
Language | English |
License | This article is made available under the Elsevier license. Copyright © 2017 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved. |
LinkModel | DirectLink |
MergedId | FETCHMERGED-LOGICAL-c455t-391835e3e5cb331cad1e76e27064a9faf03504b94e0a2f246f7f0f86dbe9da503 |
Notes | ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Undefined-1 ObjectType-Feature-3 content type line 23 |
OpenAccessLink | https://www.sciencedirect.com/science/article/pii/S1063458417300456 |
PMID | 28189828 |
PQID | 1867985093 |
PQPubID | 23479 |
PageCount | 6 |
ParticipantIDs | proquest_miscellaneous_1867985093 crossref_primary_10_1016_j_joca_2017_01_014 pubmed_primary_28189828 elsevier_sciencedirect_doi_10_1016_j_joca_2017_01_014 elsevier_clinicalkeyesjournals_1_s2_0_S1063458417300456 |
PublicationCentury | 2000 |
PublicationDate | 2017-07-01 |
PublicationDateYYYYMMDD | 2017-07-01 |
PublicationDate_xml | – month: 07 year: 2017 text: 2017-07-01 day: 01 |
PublicationDecade | 2010 |
PublicationPlace | England |
PublicationPlace_xml | – name: England |
PublicationTitle | Osteoarthritis and cartilage |
PublicationTitleAlternate | Osteoarthritis Cartilage |
PublicationYear | 2017 |
Publisher | Elsevier Ltd |
Publisher_xml | – name: Elsevier Ltd |
References | Marshall, Nicholls, Kwok, Peat, Kloppenburg, van der Windt (bib9) 2013 Yusuf, Nelissen, Ioan-Facsinay, Stojanovic-Susulic, DeGroot, van Osch (bib12) 2010; 69 Hoeven, Kavousi, Clockaerts, Kerkhof, van Meurs, Franco (bib14) 2013; 72 Stürmer, Sun, Sauerland, Zeissig, Günther, Puhl (bib7) 1998; 25 Watt (bib13) 2015; 83 Frey, Hügle, Jick, Meier, Spoendlin (bib3) 2016; 24 Dahaghin, Bierma-Zeinstra, Koes, Hazes, Pols (bib5) 2007; 66 Herrett, Gallagher, Bhaskaran, Forbes, Mathur, van Staa (bib11) 2015; 44 Bush, Bérubé, Beier (bib10) 2015; 23 Nieves-Plaza, Castro-Santana, Font, Mayor, Vilá (bib4) 2013; 19 Visser, de Mutsert, le Cessie, den Heijer, Rosendaal, Kloppenburg (bib1) 2014 Velasquez, Katz (bib6) 2010; 8 Addimanda, Mancarella, Dolzani, Ramonda, Fioravanti, Brusi (bib2) 2012; 41 Al-arfaj (bib8) 2003; 966 Bay-Jensen, Slagboom, Chen-An, Alexandersen, Qvist, Christiansen (bib15) 2013; 20 Addimanda (10.1016/j.joca.2017.01.014_bib2) 2012; 41 Marshall (10.1016/j.joca.2017.01.014_bib9) 2013 Yusuf (10.1016/j.joca.2017.01.014_bib12) 2010; 69 Stürmer (10.1016/j.joca.2017.01.014_bib7) 1998; 25 Frey (10.1016/j.joca.2017.01.014_bib3) 2016; 24 Visser (10.1016/j.joca.2017.01.014_bib1) 2014 Dahaghin (10.1016/j.joca.2017.01.014_bib5) 2007; 66 Watt (10.1016/j.joca.2017.01.014_bib13) 2015; 83 Al-arfaj (10.1016/j.joca.2017.01.014_bib8) 2003; 966 Bush (10.1016/j.joca.2017.01.014_bib10) 2015; 23 Bay-Jensen (10.1016/j.joca.2017.01.014_bib15) 2013; 20 Herrett (10.1016/j.joca.2017.01.014_bib11) 2015; 44 Hoeven (10.1016/j.joca.2017.01.014_bib14) 2013; 72 Nieves-Plaza (10.1016/j.joca.2017.01.014_bib4) 2013; 19 Velasquez (10.1016/j.joca.2017.01.014_bib6) 2010; 8 |
References_xml | – volume: 966 start-page: 2002 year: 2003 end-page: 2004 ident: bib8 article-title: Radiographic osteoarthritis and serum cholesterol publication-title: Saudi Med J contributor: fullname: Al-arfaj – start-page: 136 year: 2013 end-page: 141 ident: bib9 article-title: Erosive osteoarthritis: a more severe form of radiographic hand osteoarthritis rather than a distinct entity? publication-title: Ann Rheum Dis contributor: fullname: van der Windt – start-page: 1 year: 2014 end-page: 6 ident: bib1 article-title: The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study publication-title: Ann Rheum Dis contributor: fullname: Kloppenburg – volume: 66 start-page: 916 year: 2007 end-page: 920 ident: bib5 article-title: Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study publication-title: Ann Rheum Dis contributor: fullname: Pols – volume: 41 start-page: 310 year: 2012 end-page: 313 ident: bib2 article-title: Clinical associations in patients with hand osteoarthritis publication-title: Scand J Rheumatol contributor: fullname: Brusi – volume: 23 start-page: 503 year: 2015 end-page: 506 ident: bib10 article-title: A new prescription for growth? Statins, cholesterol and cartilage homeostasis publication-title: Osteoarthritis Cartilage contributor: fullname: Beier – volume: 19 start-page: 1 year: 2013 end-page: 6 ident: bib4 article-title: Association of hand or knee osteoarthritis with diabetes mellitus in a population of Hispanics from Puerto Rico publication-title: J Clin Rheumatol contributor: fullname: Vilá – volume: 25 start-page: 1827 year: 1998 end-page: 1832 ident: bib7 article-title: Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study publication-title: J Rheumatol contributor: fullname: Puhl – volume: 8 start-page: 295 year: 2010 end-page: 305 ident: bib6 article-title: Osteoarthritis: another component of metabolic syndrome? publication-title: Metab Syndr Relat Disord contributor: fullname: Katz – volume: 44 start-page: 827 year: 2015 end-page: 836 ident: bib11 article-title: Data resource profile: clinical practice research Datalink (CPRD) publication-title: Int J Epidemiol contributor: fullname: van Staa – volume: 83 start-page: 13 year: 2015 end-page: 18 ident: bib13 article-title: Hand osteoarthritis, menopause and menopausal hormone therapy publication-title: Maturitas contributor: fullname: Watt – volume: 69 start-page: 761 year: 2010 end-page: 765 ident: bib12 article-title: Association between weight or body mass index and hand osteoarthritis: a systematic review publication-title: Ann Rheum Dis contributor: fullname: van Osch – volume: 72 start-page: 646 year: 2013 end-page: 651 ident: bib14 article-title: Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study publication-title: Ann Rheum Dis contributor: fullname: Franco – volume: 24 start-page: 1535 year: 2016 end-page: 1540 ident: bib3 article-title: Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case-control analysis publication-title: Osteoarthritis Cartilage contributor: fullname: Spoendlin – volume: 20 start-page: 578 year: 2013 end-page: 586 ident: bib15 article-title: Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis publication-title: Menopause contributor: fullname: Christiansen – volume: 69 start-page: 761 issue: 4 year: 2010 ident: 10.1016/j.joca.2017.01.014_bib12 article-title: Association between weight or body mass index and hand osteoarthritis: a systematic review publication-title: Ann Rheum Dis doi: 10.1136/ard.2008.106930 contributor: fullname: Yusuf – volume: 20 start-page: 578 issue: 5 year: 2013 ident: 10.1016/j.joca.2017.01.014_bib15 article-title: Role of hormones in cartilage and joint metabolism: understanding an unhealthy metabolic phenotype in osteoarthritis publication-title: Menopause doi: 10.1097/gme.0b013e3182745993 contributor: fullname: Bay-Jensen – volume: 41 start-page: 310 issue: 4 year: 2012 ident: 10.1016/j.joca.2017.01.014_bib2 article-title: Clinical associations in patients with hand osteoarthritis publication-title: Scand J Rheumatol doi: 10.3109/03009742.2012.656699 contributor: fullname: Addimanda – start-page: 1 year: 2014 ident: 10.1016/j.joca.2017.01.014_bib1 article-title: The relative contribution of mechanical stress and systemic processes in different types of osteoarthritis: the NEO study publication-title: Ann Rheum Dis contributor: fullname: Visser – volume: 66 start-page: 916 issue: 7 year: 2007 ident: 10.1016/j.joca.2017.01.014_bib5 article-title: Do metabolic factors add to the effect of overweight on hand osteoarthritis? The Rotterdam Study publication-title: Ann Rheum Dis doi: 10.1136/ard.2005.045724 contributor: fullname: Dahaghin – volume: 83 start-page: 13 year: 2015 ident: 10.1016/j.joca.2017.01.014_bib13 article-title: Hand osteoarthritis, menopause and menopausal hormone therapy publication-title: Maturitas doi: 10.1016/j.maturitas.2015.09.007 contributor: fullname: Watt – volume: 23 start-page: 503 issue: 4 year: 2015 ident: 10.1016/j.joca.2017.01.014_bib10 article-title: A new prescription for growth? Statins, cholesterol and cartilage homeostasis publication-title: Osteoarthritis Cartilage doi: 10.1016/j.joca.2015.01.002 contributor: fullname: Bush – start-page: 136 year: 2013 ident: 10.1016/j.joca.2017.01.014_bib9 article-title: Erosive osteoarthritis: a more severe form of radiographic hand osteoarthritis rather than a distinct entity? publication-title: Ann Rheum Dis contributor: fullname: Marshall – volume: 44 start-page: 827 issue: 3 year: 2015 ident: 10.1016/j.joca.2017.01.014_bib11 article-title: Data resource profile: clinical practice research Datalink (CPRD) publication-title: Int J Epidemiol doi: 10.1093/ije/dyv098 contributor: fullname: Herrett – volume: 966 start-page: 2002 issue: April year: 2003 ident: 10.1016/j.joca.2017.01.014_bib8 article-title: Radiographic osteoarthritis and serum cholesterol publication-title: Saudi Med J contributor: fullname: Al-arfaj – volume: 19 start-page: 1 issue: 1 year: 2013 ident: 10.1016/j.joca.2017.01.014_bib4 article-title: Association of hand or knee osteoarthritis with diabetes mellitus in a population of Hispanics from Puerto Rico publication-title: J Clin Rheumatol doi: 10.1097/RHU.0b013e31827cd578 contributor: fullname: Nieves-Plaza – volume: 72 start-page: 646 issue: 5 year: 2013 ident: 10.1016/j.joca.2017.01.014_bib14 article-title: Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2011-201178 contributor: fullname: Hoeven – volume: 24 start-page: 1535 year: 2016 ident: 10.1016/j.joca.2017.01.014_bib3 article-title: Type II diabetes mellitus and incident osteoarthritis of the hand: a population-based case-control analysis publication-title: Osteoarthritis Cartilage doi: 10.1016/j.joca.2016.04.005 contributor: fullname: Frey – volume: 8 start-page: 295 issue: 4 year: 2010 ident: 10.1016/j.joca.2017.01.014_bib6 article-title: Osteoarthritis: another component of metabolic syndrome? publication-title: Metab Syndr Relat Disord doi: 10.1089/met.2009.0110 contributor: fullname: Velasquez – volume: 25 start-page: 1827 issue: 9 year: 1998 ident: 10.1016/j.joca.2017.01.014_bib7 article-title: Serum cholesterol and osteoarthritis. The baseline examination of the Ulm Osteoarthritis Study publication-title: J Rheumatol contributor: fullname: Stürmer |
SSID | ssj0003110 |
Score | 2.4449704 |
Snippet | Abstract Objective Preclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand... Preclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand (HOA), but evidence from... OBJECTIVEPreclinical evidence suggests that increased cholesterol levels might be involved in the pathophysiology of osteoarthritis of the hand (HOA), but... |
SourceID | proquest crossref pubmed elsevier |
SourceType | Aggregation Database Index Database Publisher |
StartPage | 1040 |
SubjectTerms | Adult Age Distribution Aged Aged, 80 and over Body Mass Index Case-control Case-Control Studies Clinical practice research datalink Female Hand Joints Hand osteoarthritis Humans Hyperlipidaemia Hyperlipidemias - complications Male Middle Aged Observational Osteoarthritis - etiology Rheumatology Risk Factors Sex Distribution |
Title | Hyperlipidaemia and incident osteoarthritis of the hand: a population-based case-control study |
URI | https://www.clinicalkey.es/playcontent/1-s2.0-S1063458417300456 https://dx.doi.org/10.1016/j.joca.2017.01.014 https://www.ncbi.nlm.nih.gov/pubmed/28189828 https://search.proquest.com/docview/1867985093 |
Volume | 25 |
hasFullText | 1 |
inHoldings | 1 |
isFullTextHit | |
isPrint | |
link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3di9QwEB_OE8QX8dv1Y4ngm8Rtmo82vp2Hx6rcvejBPhmmbcr10O5yu_fq3-5Mmy6InA9CKbS0JJlJ5iMz8wvAm5pcCu_yWuZWR0ka30kktSHLyhv0WOVZydXIp2dueW4-r-zqAI6nWhhOq0yyf5Tpg7RObxaJmotN1y2-kjOjOcqnGHKd7ACSw4ztyUV8qw97aaxVQiRwWvLXqXBmzPG6JH3B6V3FAN2pzE3K6Sbjc1BCJ_fhXrIexdHYwQdwEPuHcOc0xccfwfcluZVXP7pN12D82aHAvhG8m87luILrOdY0uIsByEisW0HWn-Ct8_cCxWZ_lJdk1daImu4ypbKLAYb2MZyffPx2vJTpBAVZG2t3UntasTbqaOtKa1Vjo2LhYl6QIYK-xZbjiobYEjPM29y4tmiztnRNFX2DNtNP4LBf9_EZCOXKAqsMta7QePRl6TEr6rYyjmWAncHbiXRhMwJlhCmD7DIwoQMTOmSKLjODYqJumEpASWjFbVpB26DCNg9Z-IvLM7D7P_-YKIF0wD9bfD0xMdAK4rAI9nF9TS0x5mBJhpOewdORu_sRMFaWJ6f0-X-2-gLu8tOY3_sSDndX1_EVWTG7ag633v1Sc7h99OnL8mw-TNrfvO_wqQ |
link.rule.ids | 315,786,790,3525,4521,24144,27957,27958,45620,45714,45909 |
linkProvider | Elsevier |
linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV1La9wwEB7SDbS5lL67bZOq0FsRa1kPW72FkOA02b00gZwqZFsmDq13yW7-f2ZseaGU9BAwPlgIWTPSPDQznwC-VuhSWJNWPNUycNT4hntUGzwvrfLWl2mSUzXyfGGKS_XjSl_twNFYC0NplVH2DzK9l9bxyyxSc7Zq29lPdGYkRfkEQa6jHfAEdpXOhJrA7uHpWbHYCmQpIiiBkZw6xNqZIc3rBlUGZXhlPXqnUA_pp4fsz14PnbyA59GAZIfDP76EndC9gqfzGCJ_Db8K9Cxvf7ertvbhT-uZ72pGB-pUkcuopGOJ87vusYzYsmFoADI6Pf_OPFttb_PipN1qVuGbx2x21iPRvoHLk-OLo4LHSxR4pbTecGlx0-ogg65KKUXlaxEyE9IMbRFvG99QaFEhZ0Li0yZVpsmapMlNXQZbe53ItzDpll14D0yYPPNl4qUsvbLe5rn1SVY1pTIkBvQUvo2kc6sBK8ONSWQ3jgjtiNAuEfioKWQjdd1YBYpyK6zjJlo74dapS9w_jJ6C3vb8a604VAP_HfHLyESHm4giI74LyzsciWAHc7Sd5BTeDdzdzoDgsiz6pR8eOepneFZczM_d-eni7CPsUcuQ7vsJJpvbu7CPRs2mPIiL9h5MT_JS |
openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Hyperlipidaemia+and+incident+osteoarthritis+of+the+hand%3A+a+population-based+case-control+study&rft.jtitle=Osteoarthritis+and+cartilage&rft.au=Frey%2C+Noel%2C+MSc&rft.au=Huegle%2C+Thomas%2C+MD%2C+PhD&rft.au=Jick%2C+Susan+S.%2C+DSc&rft.au=Meier%2C+Christoph+R.%2C+PhD%2C+MSc&rft.date=2017-07-01&rft.issn=1063-4584&rft.eissn=1522-9653&rft_id=info:doi/10.1016%2Fj.joca.2017.01.014&rft.externalDocID=1_s2_0_S1063458417300456 |
thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1063-4584&client=summon |
thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1063-4584&client=summon |
thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1063-4584&client=summon |