Development of small molecules targeting the pseudokinase Her3 - Lim, Sang Min; Xie, Ting; Westover, Kenneth D.; Ficarro, Scott B.; Tae, Hyun Seop; Gurbani, Deepak; Sim, Taebo; Marto, Jarrod A.; Jänne, Pasi A.; Crews, Craig M.; Gray, Nathanael S. (Bioorganic & medicinal chemistry letters, 2015)
Keywords: Acrylamides - chemical synthesis; Acrylamides - chemistry; Acrylamides - pharmacology; Adenine - analogs & derivatives; Adenine - chemical synthesis; Adenine - chemistry; Adenine - pharmacology; Cancer; Cell Line, Tumor; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Drug Delivery Systems; Drug Screening Assays, Antitumor; Her3; Humans; Hydrophobic tagging; Inhibitory Concentration 50; Life Sciences & Biomedicine; Molecular Structure; Pharmacology & Pharmacy; Physical Sciences; Pseudokinase; Pyrazoles - chemical synthesis; Pyrazoles - chemistry; Pyrazoles - pharmacology; Pyrazolopyrimidine; Pyrimidines - chemical synthesis; Pyrimidines - chemistry; Pyrimidines - pharmacology; Receptor, ErbB-3 - antagonists & inhibitors; Science & Technology; Small Molecule Libraries - chemical synthesis; Small Molecule Libraries - chemistry; Small Molecule Libraries - pharmacology; Hydrophobic tagging; Pseudokinase; Pyrazolopyrimidine; Her3; Cancer; DOMAIN; PROTEIN; TYROSINE KINASE; DISCOVERY; LUNG-CANCER; POTENT; ERBB3; SELECTIVE INHIBITORS; DEGRADATION; EXTENDED 5-SUBSTITUENT