Dietary docosahexaenoic acid reduces fat deposition and alleviates liver damage induced by D-galactosamine and lipopolysaccharides in Nile tilapia (Oreochromis niloticus)

• Published in: Comparative biochemistry and physiology. Toxicology & pharmacology Vol. 268; p. 109603
• Main Authors: Liu, Yi-Chan, Limbu, Samwel Mchele, Wang, Jin-Gang, Wang, Mai, Chen, Li-Qiao, Qiao, Fang, Luo, Yuan, Zhang, Mei-Ling, Du, Zhen-Yu
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.06.2023
• Subjects: alanine transaminase; Animal Feed - analysis; Animals; apoptosis; aquaculture; aspartate transaminase; blood serum; Cichlids - metabolism; diet; Diet - veterinary; Dietary Supplements; Docosahexaenoic acid; Docosahexaenoic Acids - metabolism; Docosahexaenoic Acids - pharmacology; Galactosamine - metabolism; Galactosamine - toxicity; Highly unsaturated fatty acids; inflammation; Inflammation - metabolism; lipid content; Lipid metabolism; lipogenesis; lipopolysaccharides; Lipopolysaccharides - metabolism; Lipopolysaccharides - toxicity; liver; Liver - metabolism; liver diseases; Liver health; Oreochromis niloticus; Sustainable aquaculture; Toll-like receptor 4; Toll-Like Receptor 4 - metabolism; transcriptomics; triacylglycerols; Liver health; Sustainable aquaculture; Highly unsaturated fatty acids; Lipid metabolism; Docosahexaenoic acid

Liver health is important to maintain survival and growth of fish. Currently, the role of dietary docosahexaenoic acid (DHA) in improving fish liver health is largely unknown. This study investigated the role of DHA supplementation in fat deposition and liver damage caused by D-galactosamine (D-GalN...