Chimeric flavivirus causes vascular leakage and bone marrow suppression in a mouse model

• Published in: Biochemical and biophysical research communications Vol. 659; pp. 54 - 61
• Main Authors: Kurosu, Takeshi, Hanabara, Keiko, Asai, Azusa, Pambudi, Sabar, Phanthanawiboon, Supranee, Omokoko, Magot Diata, Sakai, Yusuke, Suzuki, Tadaki, Ikuta, Kazuyoshi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.06.2023
• Subjects: Animals; Antibodies, Viral; bone marrow; Bone Marrow - pathology; Bone marrow suppression; Dengue; Dengue Virus; Flavivirus; Hemorrhagic fever; Humans; intestines; Japanese encephalitis virus; liver; megakaryocytes; Mice; Mice, Knockout; Mouse model; Vascular leakage; viruses; Bone marrow suppression; Hemorrhagic fever; Mouse model; Dengue virus; Vascular leakage; Flavivirus

Previously, we demonstrated the utility of a recombinant chimeric flavivirus (DV2ChimV), which carries the premembrane (prM) and envelope (E) genes of a type 2 DENV clinical (Thai) isolate on a backbone of Japanese encephalitis virus, for evaluating the protective efficacy of antidengue envelope ant...