Interactome Profiling of N-Terminus-Truncated NS1 Protein of Influenza A Virus Reveals Role of 14-3-3γ in Virus Replication

• Published in: Pathogens (Basel) Vol. 11; no. 7; p. 733
• Main Authors: Kuo, Rei-Lin, Tam, Ee-Hong, Woung, Chian-Huey, Hung, Chu-Mi, Liu, Hao-Ping, Liu, Helene Minyi, Wu, Chih-Ching
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 27.06.2022; MDPI
• Subjects: 14-3-3 protein; 14-3-3γ; Apoptosis; C-Terminus; Cell cycle; Disease transmission; Gene expression; Immunoprecipitation; Infections; Influenza; Influenza A; Influenza A virus; interactome; Kinases; Mass spectrometry; mutants; N-Terminus; N-terminus-truncated NS1; Neutrophils; NS1 protein; Pandemics; Phosphorylation; precipitin tests; Proteins; Replication; Scientific imaging; Signal transduction; Swine flu; Viral infections; Virulence; Virulence factors; virus replication; Viruses

Influenza A virus is transmitted through a respiratory route and has caused several pandemics throughout history. The NS1 protein of influenza A virus, which consists of an N-terminal RNA-binding domain and a C-terminal effector domain, is considered one of the critical virulence factors during infl...