Oxidative/Nitrosative Stress and Brain Involvement in Sepsis: A Relationship Supported by Immunohistochemistry

• Published in: Medicina (Kaunas, Lithuania) Vol. 60; no. 12; p. 1949
• Main Authors: Bertozzi, Giuseppe, Ferrara, Michela, Calvano, Mariagrazia, Pascale, Natascha, Di Fazio, Aldo
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.12.2024
• Subjects: 8-Hydroxy-2'-Deoxyguanosine - analysis; 8-OHdG; Adult; Aged; Aged, 80 and over; Amino acids; Antioxidants; Autopsies; B cells; Blood-brain barrier; Brain; Brain - metabolism; Case studies; Fatty acids; Female; Free radicals; Humans; Immunohistochemistry; Immunohistochemistry - methods; Infections; iNOS; Male; Middle Aged; NADPH Oxidase 2 - metabolism; Neurons; Nitric oxide; Nitric Oxide Synthase Type II - analysis; Nitric Oxide Synthase Type II - metabolism; nitrosative stress; Nitrosative Stress - physiology; NOX-2; Oxidative stress; Oxidative Stress - physiology; Proteins; Sepsis; Sepsis - complications; Sepsis - metabolism; Septic shock; Tumor necrosis factor-TNF; nitrosative stress; NT; iNOS; immunohistochemistry; NOX-2; brain; sepsis; 8-OHdG

Background and Objectives: A large amount of recent evidence suggests that cellular inability to consume oxygen could play a notable part in promoting sepsis as a consequence of mitochondrial dysfunction and oxidative stress. The latter could, in fact, represent a fundamental stage in the evolution...