Development of a simple, sensitive and selective colorimetric aptasensor for the detection of cancer-derived exosomes

• Published in: Biosensors & bioelectronics Vol. 169; p. 112576
• Main Authors: Xu, Lizhou, Chopdat, Raheemah, Li, Danyang, Al-Jamal, Khuloud T.
• Format: Journal Article
• Language: English
• Published: England Elsevier B.V 01.12.2020
• Subjects: absorbance; aldimines; Aptamer; Aptamers, Nucleotide; Aptasensor; aptasensors; Biosensing Techniques; breasts; Cancer diagnosis; catalytic activity; color; Colorimetry; detection limit; dopamine; Exosome; Exosomes; HER2; Humans; Hydrogen Peroxide; Integrin αvβ6; integrins; latex; Neoplasms - diagnosis; oligonucleotides; peroxidase; point-of-care systems; polymerization; Integrin αvβ6; Aptamer; Cancer diagnosis; HER2; Exosome; Aptasensor

There is a growing need for cancerous exosome detection towards potential non-invasive cancer diagnosis. This study aims to develop a reliable colorimetric aptasensor for sensitive and specific detection of circulating cancer-derived exosomes. In this design, target exosomes were firstly captured by...