Evaluation of the effects of Astragalus polysaccharides as immunostimulants on the immune response of crucian carp and against SVCV in vitro and in vivo

• Published in: Comparative biochemistry and physiology. Toxicology & pharmacology Vol. 253; p. 109249
• Main Authors: Liu, Jia, Zhang, Peijun, Wang, Bo, Lu, Yuting, Li, Liang, Li, Yuehong, Liu, Shaojun
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2022
• Subjects: Adjuvants, Immunologic - pharmacology; Animal Feed; Animals; Antiviral Agents - pharmacology; antiviral properties; apoptosis; Apoptosis - drug effects; Astragalus; Astragalus Plant - chemistry; Astragalus polysaccharides; Carassius; Carps - immunology; Carps - virology; Cells, Cultured; Dietary Supplements; fish; Fish Diseases - drug therapy; Fish Diseases - virology; Fish Proteins - genetics; Gene Expression - drug effects; Immune response; Immunostimulant; immunostimulants; interleukin-10; interleukin-8; intestines; kidneys; liver; polysaccharides; Polysaccharides - pharmacology; spleen; SVCV; viral load; Viremia - drug therapy; Viremia - mortality; Viremia - veterinary; Immunostimulant; SVCV; Astragalus polysaccharides; Immune response

This experiment was conducted to evaluate the immunomodulatory effect and antiviral activity of Astragalus polysaccharides (APS) in crucian carp and epithelioma papulosum cyprinid (EPC) cells. Two diets containing 0 and 2 g/kg, APS were fed crucian carp for 56 days. The results showed that supplemen...