Gene delivery methods and genome editing of human pluripotent stem cells

Induced pluripotent stem cells derived from normal somatic cells could be utilized to study tumorigenesis through overexpression of specific oncogenes, downregulation of tumor suppressors and dysregulation of other factors thought to promote tumorigenesis. Therefore, effective approaches that provid...

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Published inReports of practical oncology and radiotherapy Vol. 24; no. 2; pp. 180 - 187
Main Authors Czerwińska, Patrycja, Mazurek, Sylwia, Kołodziejczak, Iga, Wiznerowicz, Maciej
Format Journal Article
LanguageEnglish
Published Netherlands Elsevier B.V 01.03.2019
Elsevier
Subjects
CRISPR/Cas9
Genome editing
Induced pluripotent stem cells
Review
Stem cells
TALEN
ZFN
Genome editing
ZFN
CRISPR/Cas9
Induced pluripotent stem cells
TALEN
Stem cells
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Abstract Induced pluripotent stem cells derived from normal somatic cells could be utilized to study tumorigenesis through overexpression of specific oncogenes, downregulation of tumor suppressors and dysregulation of other factors thought to promote tumorigenesis. Therefore, effective approaches that provide direct modifications of induced pluripotent stem cell genome are extremely needed. Emerging strategies are expected to provide the ability to more effectively introduce diverse genetic alterations, from as small as single-nucleotide modifications to whole gene amplification or deletion, all with a high degree of target specificity. To date, several techniques have been applied in stem cell studies to directly edit cell genome (ZFNs, TALENs or CRISPR/Cas9). In this review, we summarize specific gene delivery strategies that were applied to stem cell studies together with genome editing techniques, which enable a direct modification of endogenous DNA sequences in the context of cancer studies.
AbstractList Induced pluripotent stem cells derived from normal somatic cells could be utilized to study tumorigenesis through overexpression of specific oncogenes, downregulation of tumor suppressors and dysregulation of other factors thought to promote tumorigenesis. Therefore, effective approaches that provide direct modifications of induced pluripotent stem cell genome are extremely needed. Emerging strategies are expected to provide the ability to more effectively introduce diverse genetic alterations, from as small as single-nucleotide modifications to whole gene amplification or deletion, all with a high degree of target specificity. To date, several techniques have been applied in stem cell studies to directly edit cell genome (ZFNs, TALENs or CRISPR/Cas9). In this review, we summarize specific gene delivery strategies that were applied to stem cell studies together with genome editing techniques, which enable a direct modification of endogenous DNA sequences in the context of cancer studies.
Author Mazurek, Sylwia
Czerwińska, Patrycja
Wiznerowicz, Maciej
Kołodziejczak, Iga
AuthorAffiliation b Department of Cancer Immunology, Chair of Medical Biotechnology, Poznan University of Medical Sciences, Poznan, Poland
c Postgraduate School of Molecular Medicine, Medical University of Warsaw, Warsaw, Poland
a Laboratory of Gene Therapy, Department of Diagnostics and Cancer Immunology, Greater Poland Cancer Centre, Poznan, Poland
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Keywords Genome editing
ZFN
CRISPR/Cas9
Induced pluripotent stem cells
TALEN
Stem cells
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Address: Greater Poland Cancer Centre, Laboratory of Gene Therapy, 15th Garbary Street, 61-866 Poznan, Poland.
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Snippet Induced pluripotent stem cells derived from normal somatic cells could be utilized to study tumorigenesis through overexpression of specific oncogenes,...
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SubjectTerms CRISPR/Cas9
Genome editing
Induced pluripotent stem cells
Review
Stem cells
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Title Gene delivery methods and genome editing of human pluripotent stem cells
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