Knockdown of SASS6 reduces growth of MDA‑MB‑231 triple‑negative breast cancer cells through arrest of the cell cycle at the G2/M phase

• Published in: Oncology reports Vol. 45; no. 6; p. 1
• Main Authors: Du, Lili, Jing, Jiexian, Wang, Yan, Xu, Xiaoqin, Sun, Ting, Shi, Yanchun, Wang, Weigang, Tian, Baoguo, Han, Cunzhi, Zhao, Xianwen, Chang, Huibo
• Format: Journal Article
• Language: English
• Published: Greece Spandidos Publications 01.06.2021; Spandidos Publications UK Ltd
• Subjects: Analysis; Breast cancer; Cancer cells; Cancer therapies; Cell cycle; Cell growth; Clinical trials; Ethylenediaminetetraacetic acid; Flow cytometry; Growth; Health aspects; Immunohistochemistry; Infections; Kinases; Medical prognosis; Medical research; Medicine, Experimental; Patients; Proteins; Scientific equipment and supplies industry; United States; Switzerland; China; cyclin B1; G2/M phase arrest; cyclin dependent kinase 1; spindle assembly abnormal protein 6 homolog; triple‑negative breast cancer; knockdown

Spindle assembly abnormal protein 6 homolog (SASS6) is crucial for centriole duplication; however, the role of SASS6 in the proliferation of cancer cells remains unclear. In the present study, the expression and functional role of SASS6 in triple negative breast cancer (TNBC) was assessed. Immunohis...