Design and Synthesis of Fluoro Analogues of Vitamin D

• Published in: International journal of molecular sciences Vol. 22; no. 15; p. 8191
• Main Authors: Kawagoe, Fumihiro, Mototani, Sayuri, Kittaka, Atsushi
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 01.08.2021; MDPI
• Subjects: A-ring; Biological activity; CD-ring; Drug dosages; Electronegativity; Fluorine; Metabolism; metabolite; Metabolites; Molecular structure; Oxidation; Proteins; Review; synthesis; Toxicity; Vitamin D; Vitamin D3

The discovery of a large variety of functions of vitamin D3 and its metabolites has led to the design and synthesis of a vast amount of vitamin D3 analogues in order to increase the potency and reduce toxicity. The introduction of highly electronegative fluorine atom(s) into vitamin D3 skeletons alt...