Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice
Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have potential applications in regenerative medicine. UCMSCs have been demonstrated to repair tissue damage in many inflammatory and degenerative diseases. We have previously shown that UCMSC exosomes reduce nerve injury-induced pain in rats....
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| Published in | International journal of molecular sciences Vol. 22; no. 13; p. 6664 |
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| Main Authors | , , , , , , , , , , |
| Format | Journal Article |
| Language | English |
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22.06.2021
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| Abstract | Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have potential applications in regenerative medicine. UCMSCs have been demonstrated to repair tissue damage in many inflammatory and degenerative diseases. We have previously shown that UCMSC exosomes reduce nerve injury-induced pain in rats. In this study, we characterized UCMSC exosomes using RNA sequencing and proteomic analyses and investigated their protective effects on cisplatin-induced hearing loss in mice. Two independent experiments were designed to investigate the protective effects on cisplatin-induced hearing loss in mice: (i) chronic intraperitoneal cisplatin administration (4 mg/kg) once per day for 5 consecutive days and intraperitoneal UCMSC exosome (1.2 μg/μL) injection at the same time point; and (ii) UCMSC exosome (1.2 μg/μL) injection through a round window niche 3 days after chronic cisplatin administration. Our data suggest that UCMSC exosomes exert protective effects in vivo. The post-traumatic administration of UCMSC exosomes significantly improved hearing loss and rescued the loss of cochlear hair cells in mice receiving chronic cisplatin injection. Neuropathological gene panel analyses further revealed the UCMSC exosomes treatment led to beneficial changes in the expression levels of many genes in the cochlear tissues of cisplatin-injected mice. In conclusion, UCMSC exosomes exerted protective effects in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair. |
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| AbstractList | Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have potential applications in regenerative medicine. UCMSCs have been demonstrated to repair tissue damage in many inflammatory and degenerative diseases. We have previously shown that UCMSC exosomes reduce nerve injury-induced pain in rats. In this study, we characterized UCMSC exosomes using RNA sequencing and proteomic analyses and investigated their protective effects on cisplatin-induced hearing loss in mice. Two independent experiments were designed to investigate the protective effects on cisplatin-induced hearing loss in mice: (i) chronic intraperitoneal cisplatin administration (4 mg/kg) once per day for 5 consecutive days and intraperitoneal UCMSC exosome (1.2 μg/μL) injection at the same time point; and (ii) UCMSC exosome (1.2 μg/μL) injection through a round window niche 3 days after chronic cisplatin administration. Our data suggest that UCMSC exosomes exert protective effects in vivo. The post-traumatic administration of UCMSC exosomes significantly improved hearing loss and rescued the loss of cochlear hair cells in mice receiving chronic cisplatin injection. Neuropathological gene panel analyses further revealed the UCMSC exosomes treatment led to beneficial changes in the expression levels of many genes in the cochlear tissues of cisplatin-injected mice. In conclusion, UCMSC exosomes exerted protective effects in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair.Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have potential applications in regenerative medicine. UCMSCs have been demonstrated to repair tissue damage in many inflammatory and degenerative diseases. We have previously shown that UCMSC exosomes reduce nerve injury-induced pain in rats. In this study, we characterized UCMSC exosomes using RNA sequencing and proteomic analyses and investigated their protective effects on cisplatin-induced hearing loss in mice. Two independent experiments were designed to investigate the protective effects on cisplatin-induced hearing loss in mice: (i) chronic intraperitoneal cisplatin administration (4 mg/kg) once per day for 5 consecutive days and intraperitoneal UCMSC exosome (1.2 μg/μL) injection at the same time point; and (ii) UCMSC exosome (1.2 μg/μL) injection through a round window niche 3 days after chronic cisplatin administration. Our data suggest that UCMSC exosomes exert protective effects in vivo. The post-traumatic administration of UCMSC exosomes significantly improved hearing loss and rescued the loss of cochlear hair cells in mice receiving chronic cisplatin injection. Neuropathological gene panel analyses further revealed the UCMSC exosomes treatment led to beneficial changes in the expression levels of many genes in the cochlear tissues of cisplatin-injected mice. In conclusion, UCMSC exosomes exerted protective effects in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair. Umbilical cord-derived mesenchymal stromal cells (UCMSCs) have potential applications in regenerative medicine. UCMSCs have been demonstrated to repair tissue damage in many inflammatory and degenerative diseases. We have previously shown that UCMSC exosomes reduce nerve injury-induced pain in rats. In this study, we characterized UCMSC exosomes using RNA sequencing and proteomic analyses and investigated their protective effects on cisplatin-induced hearing loss in mice. Two independent experiments were designed to investigate the protective effects on cisplatin-induced hearing loss in mice: (i) chronic intraperitoneal cisplatin administration (4 mg/kg) once per day for 5 consecutive days and intraperitoneal UCMSC exosome (1.2 μg/μL) injection at the same time point; and (ii) UCMSC exosome (1.2 μg/μL) injection through a round window niche 3 days after chronic cisplatin administration. Our data suggest that UCMSC exosomes exert protective effects in vivo. The post-traumatic administration of UCMSC exosomes significantly improved hearing loss and rescued the loss of cochlear hair cells in mice receiving chronic cisplatin injection. Neuropathological gene panel analyses further revealed the UCMSC exosomes treatment led to beneficial changes in the expression levels of many genes in the cochlear tissues of cisplatin-injected mice. In conclusion, UCMSC exosomes exerted protective effects in treating ototoxicity-induced hearing loss by promoting tissue remodeling and repair. |
| Author | Lin, Frank Chen, Chie-Pein Cheng, Ching-Chang Tsai, Stella Kao, Chien-Yu Lin, Hung-Ching Yang, Kuender Chang, Kuang-Hsi Chou, Ruey-Hwang Li, Min-Chih Hsu, Yi-Chao |
| AuthorAffiliation | 10 Center for Molecular Medicine, China Medical University Hospital, Taichung 406, Taiwan 7 General Education Center, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan 2 Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, 145, Guoguang Rd., South Dist., Taichung City 402, Taiwan 6 Graduate Institute of Biomedical Sciences, China Medical University, Taichung 406, Taiwan; rhchou@mail.cmu.edu.tw 15 Department of Audiology and Speech-Language Pathology, Mackay Medical College, New Taipei City 252, Taiwan; hclin59@mmc.edu.tw 13 Laboratory Animal Service Center, Office of Research and Development, China Medical University, Taichung 406, Taiwan; chengjzvm@gmail.com 3 Department of Medical Research, Mackay Memorial Hospital, Taipei 104, Taiwan; yangkd@mmc.edu.tw (K.D.Y.); cpchen@mmh.org.tw (C.-P.C.) 9 School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan 1 Department of Otolaryngology, Tungs’ Taichung Metroharbor Hospit |
| AuthorAffiliation_xml | – name: 5 Department of Medical Research, Tungs’ Taichung Metroharbor Hospital, Taichung 435, Taiwan; kuanghsichang@gmail.com – name: 6 Graduate Institute of Biomedical Sciences, China Medical University, Taichung 406, Taiwan; rhchou@mail.cmu.edu.tw – name: 1 Department of Otolaryngology, Tungs’ Taichung Metroharbor Hospital, Taichung 435, Taiwan; tsaistella111@gmail.com – name: 3 Department of Medical Research, Mackay Memorial Hospital, Taipei 104, Taiwan; yangkd@mmc.edu.tw (K.D.Y.); cpchen@mmh.org.tw (C.-P.C.) – name: 15 Department of Audiology and Speech-Language Pathology, Mackay Medical College, New Taipei City 252, Taiwan; hclin59@mmc.edu.tw – name: 11 Department of Medical Laboratory and Biotechnology, Asia University, Taichung 413, Taiwan – name: 4 Department of Otolaryngology, Mackay Memorial Hospital, New Taipei City 251, Taiwan – name: 9 School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan – name: 10 Center for Molecular Medicine, China Medical University Hospital, Taichung 406, Taiwan – name: 13 Laboratory Animal Service Center, Office of Research and Development, China Medical University, Taichung 406, Taiwan; chengjzvm@gmail.com – name: 2 Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, 145, Guoguang Rd., South Dist., Taichung City 402, Taiwan – name: 8 Department of Thoracic Surgery, Chung Shan Medical University Hospital, Taichung 402, Taiwan; frnklin@gmail.com – name: 14 Medical and Pharmaceutical Industry Technology and Development Center, New Taipei City 248, Taiwan; kcy7427p@gmail.com – name: 12 Institute of Biomedical Sciences, Mackay Medical College, New Taipei City 252, Taiwan; ytrewq82325@gmail.com – name: 7 General Education Center, Jen-Teh Junior College of Medicine, Nursing and Management, Miaoli 356, Taiwan |
| Author_xml | – sequence: 1 givenname: Stella orcidid: 0000-0003-2694-1207 surname: Tsai fullname: Tsai, Stella – sequence: 2 givenname: Kuender surname: Yang fullname: Yang, Kuender – sequence: 3 givenname: Kuang-Hsi orcidid: 0000-0002-4453-0068 surname: Chang fullname: Chang, Kuang-Hsi – sequence: 4 givenname: Frank orcidid: 0000-0001-5301-2345 surname: Lin fullname: Lin, Frank – sequence: 5 givenname: Ruey-Hwang surname: Chou fullname: Chou, Ruey-Hwang – sequence: 6 givenname: Min-Chih surname: Li fullname: Li, Min-Chih – sequence: 7 givenname: Ching-Chang surname: Cheng fullname: Cheng, Ching-Chang – sequence: 8 givenname: Chien-Yu surname: Kao fullname: Kao, Chien-Yu – sequence: 9 givenname: Chie-Pein surname: Chen fullname: Chen, Chie-Pein – sequence: 10 givenname: Hung-Ching surname: Lin fullname: Lin, Hung-Ching – sequence: 11 givenname: Yi-Chao orcidid: 0000-0001-9071-475X surname: Hsu fullname: Hsu, Yi-Chao |
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| Cites_doi | 10.1021/pr8010974 10.1111/jnc.14859 10.3390/ijms21010158 10.1159/000111951 10.1016/j.bbrc.2012.09.111 10.1002/term.1491 10.1002/9780470942390.mo110059 10.1096/fj.201800131RR 10.1016/j.ijporl.2016.10.010 10.1038/s41467-019-11674-z 10.1002/jnr.490370202 10.1038/s41467-018-05929-4 10.1186/s40824-016-0068-0 10.1523/JNEUROSCI.1588-12.2012 10.5966/sctm.2016-0071 10.1038/s41419-020-02743-z 10.1258/ebm.2012.011429 10.3892/mmr.2017.6784 10.1016/j.jcyt.2018.12.006 10.1016/j.ntt.2012.06.002 10.1159/000073515 10.1155/2016/6391264 10.1016/j.neulet.2013.03.018 10.1016/j.canlet.2019.02.040 10.1007/s00405-017-4470-6 10.7874/jao.2018.00115 10.1186/1741-7015-8-76 10.1080/20013078.2018.1535750 10.1097/j.pain.0000000000001395 10.21769/BioProtoc.1768 10.1053/j.gastro.2008.03.015 10.1002/ar.24346 10.1021/pr101057w 10.1186/1471-2105-6-225 10.1186/scrt194 10.1159/000075224 10.1007/s12035-017-0511-9 10.1200/JCO.1989.7.10.1457 10.1016/j.biopha.2018.02.093 10.1186/s13287-019-1136-x 10.1186/s12916-014-0219-x 10.1016/j.anl.2019.02.006 10.1111/j.1749-6632.1992.tb27492.x 10.1371/journal.pone.0046355 10.1111/j.1365-2443.2012.01623.x 10.3389/fncel.2014.00334 10.7150/thno.28021 10.1002/jnr.23616 10.1111/jcmm.14190 10.1016/j.heares.2015.08.008 10.3390/ijms21030799 10.1517/14712598.2015.1009889 10.1038/srep41099 10.1016/j.diff.2018.07.001 10.1016/j.neuropharm.2017.01.001 10.1038/s41598-018-19581-x 10.1080/20013078.2019.1596016 |
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| References | Liu (ref_17) 2018; 101 Conde (ref_41) 2017; 7 Park (ref_13) 2015; 93 Noda (ref_54) 2019; 46 ref_58 Neal (ref_60) 2015; 328 Xu (ref_11) 2019; 303 ref_51 Pugholm (ref_50) 2016; 2016 Kil (ref_7) 2016; 91 Monard (ref_46) 1992; 674 Benito (ref_38) 2012; 17 ref_16 Scotti (ref_45) 1994; 37 Liu (ref_8) 2019; 153 Zhou (ref_15) 2013; 4 Lee (ref_18) 2017; 9 Hansen (ref_28) 1989; 7 Richardson (ref_29) 2015; 15 Wu (ref_57) 2017; 116 Meng (ref_9) 2012; 237 Yin (ref_14) 2019; 11 Gopal (ref_26) 2012; 34 Rubino (ref_52) 2018; 9 Wu (ref_48) 2017; 16 Zhu (ref_6) 2013; 541 Fetoni (ref_12) 2014; 8 Bachurski (ref_35) 2019; 8 Ingham (ref_59) 2011; 1 Shiue (ref_36) 2019; 160 ref_63 Baumgartner (ref_33) 2018; 22 Teixeira (ref_47) 2016; 6 Ahmadinejad (ref_42) 2017; 274 Ling (ref_5) 2019; 10 Witwer (ref_37) 2018; 7 Chen (ref_23) 2003; 65 Hamers (ref_27) 2003; 8 Spangenberg (ref_53) 2019; 10 Kuo (ref_2) 2008; 134 Zhu (ref_40) 2018; 8 Kuo (ref_56) 2011; 10 Fan (ref_24) 2019; 450 ref_31 ref_30 Choi (ref_10) 2012; 427 Saulite (ref_4) 2017; 55 Nakagawa (ref_32) 2014; 12 Ninoyu (ref_61) 2020; 11 Yao (ref_20) 2018; 33 Zurn (ref_44) 1988; 10 Hu (ref_49) 2012; 32 Li (ref_3) 2018; 102 Nassar (ref_19) 2016; 20 Rohde (ref_34) 2019; 21 Mathias (ref_43) 2009; 8 Du (ref_39) 2018; 27 Ferguson (ref_62) 2018; 8 Ma (ref_21) 2019; 23 Cabrera (ref_22) 2015; 66 Fuentes (ref_55) 2017; 11 Baranyi (ref_25) 2019; 160 Yew (ref_1) 2012; 7 |
| References_xml | – volume: 8 start-page: 2827 year: 2009 ident: ref_43 article-title: Secretome-based proteomic profiling of Ras-transformed MDCK cells reveals extracellular modulators of epithelial-mesenchymal transition publication-title: J. Proteome Res. doi: 10.1021/pr8010974 – volume: 153 start-page: 230 year: 2019 ident: ref_8 article-title: Injury-preconditioning secretome of umbilical cord mesenchymal stem cells amplified the neurogenesis and cognitive recovery after severe traumatic brain injury in rats publication-title: J. Neurochem. doi: 10.1111/jnc.14859 – ident: ref_51 doi: 10.3390/ijms21010158 – volume: 10 start-page: 17 year: 1988 ident: ref_44 article-title: A Glia-Derived Nexin Promotes Neurite Outgrowth in Cultured Chick Sympathetic Neurons publication-title: Dev. Neurosci. doi: 10.1159/000111951 – volume: 427 start-page: 629 year: 2012 ident: ref_10 article-title: Hearing restoration in a deaf animal model with intravenous transplantation of mesenchymal stem cells derived from human umbilical cord blood publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2012.09.111 – volume: 7 start-page: 984 year: 2012 ident: ref_1 article-title: Efficient expansion of mesenchymal stem cells from mouse bone marrow under hypoxic conditions publication-title: J. Tissue Eng. Regen. Med. doi: 10.1002/term.1491 – volume: 1 start-page: 279 year: 2011 ident: ref_59 article-title: Using the Auditory Brainstem Response (ABR) to Determine Sensitivity of Hearing in Mutant Mice publication-title: Curr. Protoc. Mouse Biol. doi: 10.1002/9780470942390.mo110059 – volume: 33 start-page: 1695 year: 2018 ident: ref_20 article-title: Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate rat hepatic ischemia-reperfusion injury by suppressing oxidative stress and neutrophil inflammatory response publication-title: FASEB J. doi: 10.1096/fj.201800131RR – volume: 91 start-page: 72 year: 2016 ident: ref_7 article-title: Regenerative efficacy of mesenchymal stromal cells from human placenta in sensorineural hearing loss publication-title: Int. J. Pediatr. Otorhinolaryngol. doi: 10.1016/j.ijporl.2016.10.010 – volume: 10 start-page: 1 year: 2019 ident: ref_53 article-title: Sustained microglial depletion with CSF1R inhibitor impairs parenchymal plaque development in an Alzheimer’s disease model publication-title: Nat. Commun. doi: 10.1038/s41467-019-11674-z – volume: 37 start-page: 155 year: 1994 ident: ref_45 article-title: Re-expression of glia-derived nexin/protease nexin 1 depends on mode of lesion-induction or terminal degeneration: Observations after excitotoxin or 6-hydroxydopamine lesions of rat substantia nigra publication-title: J. Neurosci. Res. doi: 10.1002/jnr.490370202 – volume: 9 start-page: 1 year: 2018 ident: ref_52 article-title: Acute microglia ablation induces neurodegeneration in the somatosensory system publication-title: Nat. Commun. doi: 10.1038/s41467-018-05929-4 – volume: 20 start-page: 21 year: 2016 ident: ref_19 article-title: Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases publication-title: Biomater. Res. doi: 10.1186/s40824-016-0068-0 – volume: 32 start-page: 14927 year: 2012 ident: ref_49 article-title: Metalloproteinases and Their Associated Genes Contribute to the Functional Integrity and Noise-Induced Damage in the Cochlear Sensory Epithelium publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.1588-12.2012 – volume: 160 start-page: 822 year: 2019 ident: ref_25 article-title: Etiological factors of sensorineural hearing loss in children after cochlear implantation publication-title: Orv. Hetil. – volume: 66 start-page: 286 year: 2015 ident: ref_22 article-title: Perspectives for the Treatment of Sensorineural Hearing Loss by Cellular Regeneration of the Inner Ear publication-title: Acta Otorrinolaringol. – volume: 6 start-page: 634 year: 2016 ident: ref_47 article-title: Impact of the Secretome of Human Mesenchymal Stem Cells on Brain Structure and Animal Behavior in a Rat Model of Parkinson’s Disease publication-title: Stem Cells Transl. Med. doi: 10.5966/sctm.2016-0071 – volume: 11 start-page: 1 year: 2020 ident: ref_61 article-title: The integrity of cochlear hair cells is established and maintained through the localization of Dia1 at apical junctional complexes and stereocilia publication-title: Cell Death Dis. doi: 10.1038/s41419-020-02743-z – volume: 237 start-page: 709 year: 2012 ident: ref_9 article-title: Stemness gene expression profile analysis in human umbilical cord mesenchymal stem cells publication-title: Exp. Biol. Med. doi: 10.1258/ebm.2012.011429 – volume: 16 start-page: 1731 year: 2017 ident: ref_48 article-title: Matrix metalloproteinase-2 and -9 contribute to functional integrity and noise-induced damage to the blood-labyrinth-barrier publication-title: Mol. Med. Rep. doi: 10.3892/mmr.2017.6784 – volume: 21 start-page: 581 year: 2019 ident: ref_34 article-title: Manufacturing and characterization of extracellular vesicles from umbilical cord–derived mesenchymal stromal cells for clinical testing publication-title: Cytotherapy doi: 10.1016/j.jcyt.2018.12.006 – volume: 34 start-page: 495 year: 2012 ident: ref_26 article-title: d-Methionine protects against cisplatin-induced neurotoxicity in cortical networks publication-title: Neurotoxicol. Teratol. doi: 10.1016/j.ntt.2012.06.002 – volume: 8 start-page: 305 year: 2003 ident: ref_27 article-title: Cisplatin Ototoxicity Involves Organ of Corti, Stria Vascularis and Spiral Ganglion: Modulation by αMSH and ORG 2766 publication-title: Audiol. Neurotol. doi: 10.1159/000073515 – volume: 2016 start-page: 1 year: 2016 ident: ref_50 article-title: Phenotyping of Leukocytes and Leukocyte-Derived Extracellular Vesicles publication-title: J. Immunol. Res. doi: 10.1155/2016/6391264 – volume: 541 start-page: 77 year: 2013 ident: ref_6 article-title: Comparison of cell proliferation, apoptosis, cellular morphology and ultrastructure between human umbilical cord and placenta-derived mesenchymal stem cells publication-title: Neurosci. Lett. doi: 10.1016/j.neulet.2013.03.018 – volume: 450 start-page: 132 year: 2019 ident: ref_24 article-title: PTK2 promotes cancer stem cell traits in hepatocellular carcinoma by activating Wnt/beta-catenin signaling publication-title: Cancer Lett. doi: 10.1016/j.canlet.2019.02.040 – volume: 274 start-page: 2373 year: 2017 ident: ref_42 article-title: MicroRNAs: Effective elements in ear-related diseases and hearing loss publication-title: Eur. Arch. OtoRhinoLaryngol. doi: 10.1007/s00405-017-4470-6 – volume: 11 start-page: 9 year: 2017 ident: ref_55 article-title: The Role of Glia in the Peripheral and Central Auditory System Following Noise Overexposure: Contribution of TNF-alpha and IL-1beta to the Pathogenesis of Hearing Loss publication-title: Front. Neuroanat. – volume: 22 start-page: 209 year: 2018 ident: ref_33 article-title: Safety of Autologous Umbilical Cord Blood Therapy for Acquired Sensorineural Hearing Loss in Children publication-title: J. Audiol. Otol. doi: 10.7874/jao.2018.00115 – ident: ref_31 doi: 10.1186/1741-7015-8-76 – volume: 7 start-page: 1535750 year: 2018 ident: ref_37 article-title: Minimal information for studies of extracellular vesicles 2018 (MISEV2018): A position statement of the International Society for Extracellular Vesicles and update of the MISEV2014 guidelines publication-title: J. Extracell. Vesicles doi: 10.1080/20013078.2018.1535750 – volume: 160 start-page: 210 year: 2019 ident: ref_36 article-title: Mesenchymal stem cell exosomes as a cell-free therapy for nerve injury–induced pain in rats publication-title: Pain doi: 10.1097/j.pain.0000000000001395 – ident: ref_58 doi: 10.21769/BioProtoc.1768 – volume: 134 start-page: 2111 year: 2008 ident: ref_2 article-title: Stem Cell Therapy for Liver Disease: Parameters Governing the Success of Using Bone Marrow Mesenchymal Stem Cells publication-title: Gastroenterology doi: 10.1053/j.gastro.2008.03.015 – volume: 303 start-page: 494 year: 2019 ident: ref_11 article-title: Transplantation and Tracking of the Human Umbilical Cord Mesenchymal Stem Cell Labeled with Superparamagnetic Iron Oxide in Deaf Pigs publication-title: Anat. Rec. Adv. Integr. Anat. Evol. Biol. doi: 10.1002/ar.24346 – volume: 10 start-page: 1305 year: 2011 ident: ref_56 article-title: Use of Proteomic Differential Displays to Assess Functional Discrepancies and Adjustments of Human Bone Marrow- and Wharton Jelly-Derived Mesenchymal Stem Cells publication-title: J. Proteome Res. doi: 10.1021/pr101057w – ident: ref_63 doi: 10.1186/1471-2105-6-225 – volume: 4 start-page: 34 year: 2013 ident: ref_15 article-title: Exosomes released by human umbilical cord mesenchymal stem cells protect against cisplatin-induced renal oxidative stress and apoptosis in vivo and in vitro publication-title: Stem Cell Res. Ther. doi: 10.1186/scrt194 – volume: 65 start-page: 266 year: 2003 ident: ref_23 article-title: Changes of Hair Cell Stereocilia and Threshold Shift after Acoustic Trauma in Guinea Pigs: Comparison between Inner and Outer Hair Cells publication-title: ORL doi: 10.1159/000075224 – volume: 55 start-page: 2840 year: 2017 ident: ref_4 article-title: The Differentiation of Skin Mesenchymal Stem Cells Towards a Schwann Cell Phenotype: Impact of Sigma-1 Receptor Activation publication-title: Mol. Neurobiol. doi: 10.1007/s12035-017-0511-9 – volume: 7 start-page: 1457 year: 1989 ident: ref_28 article-title: Long-term neurotoxicity in patients treated with cisplatin, vinblastine, and bleomycin for metastatic germ cell cancer publication-title: J. Clin. Oncol. doi: 10.1200/JCO.1989.7.10.1457 – volume: 101 start-page: 729 year: 2018 ident: ref_17 article-title: Human umbilical cord mesenchymal stem cells improve irradiation-induced skin ulcers healing of rat models publication-title: Biomed. Pharmacother. doi: 10.1016/j.biopha.2018.02.093 – volume: 10 start-page: 1 year: 2019 ident: ref_5 article-title: Human amnion-derived mesenchymal stem cell (hAD-MSC) transplantation improves ovarian function in rats with premature ovarian insufficiency (POI) at least partly through a paracrine mechanism publication-title: Stem Cell Res. Ther. doi: 10.1186/s13287-019-1136-x – volume: 12 start-page: 1 year: 2014 ident: ref_32 article-title: A randomized controlled clinical trial of topical insulin-like growth factor-1 therapy for sudden deafness refractory to systemic corticosteroid treatment publication-title: BMC Med. doi: 10.1186/s12916-014-0219-x – volume: 46 start-page: 716 year: 2019 ident: ref_54 article-title: Microglial activation in the cochlear nucleus after early hearing loss in rats publication-title: Auris Nasus Larynx doi: 10.1016/j.anl.2019.02.006 – volume: 674 start-page: 237 year: 1992 ident: ref_46 article-title: Relevance of the Balance between Glia-Derived Nexin and Thrombin following Lesion in the Nervous System publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.1992.tb27492.x – ident: ref_30 doi: 10.1371/journal.pone.0046355 – volume: 17 start-page: 673 year: 2012 ident: ref_38 article-title: Changes in CDKN2D, TP53, and miR125a expression: Potential role in the evaluation of human amniotic fluid-derived mesenchymal stromal cell fitness publication-title: Genes Cells doi: 10.1111/j.1365-2443.2012.01623.x – volume: 8 start-page: 334 year: 2014 ident: ref_12 article-title: Grafting and Early Expression of Growth Factors from Adipose-Derived Stem Cells Transplanted into the Cochlea, in a Guinea Pig Model of Acoustic Trauma publication-title: Front. Cell. Neurosci. doi: 10.3389/fncel.2014.00334 – volume: 27 start-page: 11 year: 2018 ident: ref_39 article-title: MicroRNA-125b regulates osteogenic differentiation of human periodontal ligament stem cells publication-title: Shanghai J. Stomatol. – volume: 8 start-page: 6163 year: 2018 ident: ref_40 article-title: Hypoxia-elicited mesenchymal stem cell-derived exosomes facilitates cardiac repair through miR-125b-mediated prevention of cell death in myocardial infarction publication-title: Theranostics doi: 10.7150/thno.28021 – volume: 93 start-page: 1814 year: 2015 ident: ref_13 article-title: Human umbilical cord blood-derived mesenchymal stem cells improve functional recovery through thrombospondin1, pantraxin3, and vascular endothelial growth factor in the ischemic rat brain publication-title: J. Neurosci. Res. doi: 10.1002/jnr.23616 – volume: 9 start-page: 281 year: 2017 ident: ref_18 article-title: Human umbilical cord blood-derived mesenchymal stem cells ameliorate psoriasis-like skin inflammation in mice publication-title: Biochem. Biophys. Rep. – volume: 23 start-page: 2822 year: 2019 ident: ref_21 article-title: Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve re-generation after sciatic nerve transection in rats publication-title: J. Cell Mol. Med. doi: 10.1111/jcmm.14190 – volume: 328 start-page: 120 year: 2015 ident: ref_60 article-title: Hair cell counts in a rat model of sound damage: Effects of tissue preparation & identification of regions of hair cell loss publication-title: Heart Res. doi: 10.1016/j.heares.2015.08.008 – ident: ref_16 doi: 10.3390/ijms21030799 – volume: 15 start-page: 417 year: 2015 ident: ref_29 article-title: Atoh1 gene therapy in the cochlea for hair cell regeneration publication-title: Expert Opin. Biol. Ther. doi: 10.1517/14712598.2015.1009889 – volume: 7 start-page: srep41099 year: 2017 ident: ref_41 article-title: HIF-1α induction during reperfusion avoids maladaptive repair after renal ischemia/reperfusion involving miR127-3p publication-title: Sci. Rep. doi: 10.1038/srep41099 – volume: 102 start-page: 30 year: 2018 ident: ref_3 article-title: Comparison of phenotypes and transcriptomes of mouse skin-derived precursors and dermal mesenchymal stem cells publication-title: Differentiation doi: 10.1016/j.diff.2018.07.001 – volume: 116 start-page: 429 year: 2017 ident: ref_57 article-title: Allicin protects auditory hair cells and spiral ganglion neurons from cisplatin—Induced apoptosis publication-title: Neuropharmacol. doi: 10.1016/j.neuropharm.2017.01.001 – volume: 11 start-page: 1230 year: 2019 ident: ref_14 article-title: Human umbilical cord mesenchymal stem cells and exosomes: Bioactive ways of tissue injury repair publication-title: Am. J. Transl. Res. – volume: 8 start-page: 1419 year: 2018 ident: ref_62 article-title: The microRNA regulatory landscape of MSC-derived exosomes: A systems view publication-title: Sci. Rep. doi: 10.1038/s41598-018-19581-x – volume: 8 start-page: 1596016 year: 2019 ident: ref_35 article-title: Extracellular vesicle measurements with nanoparticle tracking analysis—An accuracy and repeatability comparison between NanoSight NS300 and ZetaView publication-title: J. Extracell. Vesicles doi: 10.1080/20013078.2019.1596016 |
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| SubjectTerms | Apoptosis Chemotherapy Deafness Flow cytometry Growth factors Hearing loss Proteins Regenerative medicine Traumatic brain injury Umbilical cord |
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| Title | Umbilical Cord Mesenchymal Stromal Cell-Derived Exosomes Rescue the Loss of Outer Hair Cells and Repair Cochlear Damage in Cisplatin-Injected Mice |
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