Silencing long non-coding RNA MEG8 inhibits the proliferation and induces the ferroptosis of hemangioma endothelial cells by regulating miR-497-5p/NOTCH2 axis

• Published in: Biochemical and biophysical research communications Vol. 556; pp. 72 - 78
• Main Authors: Ma, Qingjie, Dai, Xiaolin, Lu, Weiwei, Qu, Xiaowen, Liu, Na, Zhu, Chongtao
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.06.2021
• Subjects: Amino Acid Transport System y+ - genetics; Amino Acid Transport System y+ - metabolism; Apoptosis Regulatory Proteins - genetics; Apoptosis Regulatory Proteins - metabolism; Base Sequence; carcinogenesis; Cell Proliferation - drug effects; Cell Proliferation - genetics; cell viability; Cyclohexylamines - pharmacology; Down-Regulation; Endothelial Cells - metabolism; Endothelial Cells - pathology; Ferroptosis; Ferroptosis - drug effects; Ferroptosis - genetics; Gene Silencing - drug effects; Hemangioma; Hemangioma - genetics; Humans; Long non-coding RNA MEG8; MicroRNAs - genetics; MicroRNAs - metabolism; miR-497-5p; Mitochondrial Proteins - genetics; Mitochondrial Proteins - metabolism; non-coding RNA; NOTCH2; Phenylenediamines - pharmacology; Phospholipid Hydroperoxide Glutathione Peroxidase - genetics; Phospholipid Hydroperoxide Glutathione Peroxidase - metabolism; protein content; Quinoxalines - pharmacology; Receptor, Notch2 - biosynthesis; Receptor, Notch2 - genetics; Receptor, Notch2 - metabolism; RNA, Long Noncoding - antagonists & inhibitors; RNA, Long Noncoding - genetics; RNA, Small Interfering - genetics; Spiro Compounds - pharmacology; NOTCH2; Ferroptosis; Hemangioma; Long non-coding RNA MEG8; miR-497-5p
• ISSN: 0006-291X; 1090-2104; 1090-2104
• DOI: 10.1016/j.bbrc.2021.03.132

Even though long non-coding RNA (lncRNA) MEG8 plays vital roles in carcinogenesis of malignances, its roles and mechanisms in hemangioma remain unknown. Therefore, we evaluate the oncogenic roles of MEG8 in hemangioma. Small interfering RNA (siRNA)-mediated depletion of MEG8 inhibited the proliferat...