Associated neonatal and maternal factors of osteopenia of prematurity in low resource setting: A cross-sectional study

• Published in: Annals of medicine and surgery Vol. 64; p. 102235
• Main Authors: Angelika, Dina, Etika, Risa, Mapindra, Muhammad Pradhika, Utomo, Martono Tri, Rahardjo, Paulus, Ugrasena, I Dewa Gede
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.04.2021; Elsevier
• Subjects: Incidence; Infant factor; Maternal factor; Original Research; Osteopenia; Premature; Premature; Infant factor; Osteopenia; Maternal factor; Incidence
• ISSN: 2049-0801; 2049-0801
• DOI: 10.1016/j.amsu.2021.102235

Determining neonatal and maternal factors that are associated with the incidence of OFP. This study employed a cross-sectional design, in which the participants were identified for clinical variables (sex, gestational age, birth weight, etc.), neonatal morbidity (sepsis, necrotizing enterocolitis (NEC), etc.), and maternal risk factors (premature rupture of membranes, preeclampsia, etc.). The data were analyzed using Chi-square test, independent t-test, and logistic regression test with p < 0.05. The birth weight ranged from 800 to 1495 g (1219 ± 225 g), of which 5 newborns (17%) were <1000 g. The gestational age ranged from 27 to 32 weeks, with a mean of 29 ± 1.5 weeks. The signs of OFP were observed in 13 (43%) infants, of which 2 (15%) OFP infants had a birth weight <1000 g. There was significant difference in parenteral nutrition duration (p = 0.018), onset of vitamin D supplementation (p = 0.019), and ALP level (p = 0.012) of infants between the OFP group and the non-OFP group. The variables associated with the incidence of OFP were parenteral nutrition duration >15 days (OR = 5.4; 95% CI 1.120–26.044; p = 0.036), ALP level >500 U/L (OR = 2.889; 95% CI 1.703–4.900; p = 0.014), and PROM (OR = 5.4; 95% CI 1.039–28.533; p = 0.045). The lack of phosphate intake, prolonged parenteral nutrition, ALP level >500 U/L, onset of vitamin D supplementation, and premature rupture of membranes are associated with the incidence of OFP. •The lack of phosphate intake, prolonged parenteral nutrition, onset of vitamin D supplementation, and premature rupture of membranes are associated with the incidence of OFP.•High incidence of OFP in preterm infants with birthweight below 1500 g.•Provision of parenteral nutrition >15 days increases the risk of OFP.