Synthesis and evaluation of some new pyrazoline substituted benzenesulfonylureas as potential antiproliferative agents

• Published in: Bioorganic & medicinal chemistry letters Vol. 24; no. 7; pp. 1685 - 1691
• Main Authors: Rathore, Pooja, Yaseen, Shafiya, Ovais, Syed, Bashir, Rafia, Yaseen, Raed, Hameed, Alhamzah D., Samim, Mohammed, Gupta, Rakesh, Hussain, Firasat, Javed, Kalim
• Format: Journal Article
• Language: English
• Published: OXFORD Elsevier Ltd 01.04.2014; Elsevier
• Subjects: Anti-cancer; Antineoplastic Agents - chemical synthesis; Antineoplastic Agents - chemistry; Antineoplastic Agents - pharmacology; Antiproliferative activity; Benzenesulfonylureas; Cell Line, Tumor; Cell Proliferation - drug effects; Chemistry; Chemistry, Medicinal; Chemistry, Organic; Dose-Response Relationship, Drug; Drug Screening Assays, Antitumor; Humans; Life Sciences & Biomedicine; Molecular Structure; Pharmacology & Pharmacy; Physical Sciences; Pyrazoles - chemistry; Pyrazolines; Science & Technology; Structure-Activity Relationship; Sulfonamides; Sulfonylurea Compounds - chemical synthesis; Sulfonylurea Compounds - chemistry; Sulfonylurea Compounds - pharmacology; Benzenesulfonylureas; Anti-cancer; Antiproliferative activity; Sulfonamides; Pyrazolines; ANTICANCER AGENTS; DRUG DISCOVERY; BEARING BENZENE SULFONAMIDE; NATIONAL-CANCER-INSTITUTE; TUMORS; ANTITUMOR AGENTS; IN-VITRO; SCREEN; INHIBITORS; DERIVATIVES

Twenty six new pyrazoline substituted benzenesulfonylurea derivatives (2a–z) were synthesized and characterized. Out of these fourteen derivatives (2i, 2k–2p, 2r, 2s–2x) were evaluated for their antiproliferative activity towards 60 human cancer cell lines. Twenty six new pyrazoline substituted benz...