Differential distribution of functional cannabinoid CB1 receptors in the mouse gastroenteric tract

• Published in: European journal of pharmacology Vol. 459; no. 1; pp. 97 - 105
• Main Authors: CASU, Maria Antonietta, PORCELLA, Anna, RUIU, Stefania, SABA, Pierluigi, MARCHESE, Giorgio, CARAI, Mauro Antonio, REALI, Roberta, GESSA, Gian Luigi, PANI, Luca
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier 10.01.2003
• Subjects: Animals; Antiemetics - pharmacology; Binding, Competitive; Biological and medical sciences; Blotting, Western; Cyclohexanols - metabolism; Digestive System - chemistry; Digestive System - drug effects; Digestive System - metabolism; Dose-Response Relationship, Drug; Dronabinol - analogs & derivatives; Dronabinol - pharmacology; Drug addictions; Fundamental and applied biological sciences. Psychology; Gastric Mucosa - metabolism; Gastrointestinal Transit - drug effects; Immunohistochemistry; Intestine, Large - chemistry; Intestine, Large - metabolism; Intestine, Small - chemistry; Intestine, Small - metabolism; Intestine. Mesentery; Male; Medical sciences; Mice; Piperidines - pharmacology; Pyrazoles - pharmacology; Receptors, Cannabinoid; Receptors, Drug - analysis; Receptors, Drug - antagonists & inhibitors; Receptors, Drug - physiology; Rimonabant; Stomach - chemistry; Toxicology; Tritium; Vertebrates: digestive system; CB1 cannabinoid receptor; Drug abuse; Toxicity; Smooth muscle; Cannabinoid; Small intestine; Cannabinol; Intestinal disease; Colon; Localization; Mechanism of action; Constipation; Digestive system; Large intestin; Rodentia; Gut; Tissue specificity; Gene expression; In vitro; Vertebrata; Biological fixation; Mammalia; Mouse; Animal; Digestive diseases; Marijuana

Recently, the gastrointestinal pharmacology of cannabinoid CB(1) receptors has been extensively explored. We employed western blotting and immunohistochemistry techniques to study the distribution of the cannabinoid CB(1) receptor protein in the mouse gastroenteric tract. The cannabinoid CB(1) recep...