Broad spectrum metabolomics for detection of abnormal metabolic pathways in a mouse model for retinitis pigmentosa

• Published in: Experimental eye research Vol. 184; pp. 135 - 145
• Main Authors: Weiss, Ellen R., Osawa, Shoji, Xiong, Yubin, Dhungana, Suraj, Carlson, James, McRitchie, Susan, Fennell, Timothy R.
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.07.2019
• Subjects: Animals; Chromatography, High Pressure Liquid; Deoxynucleotide; Disease Models, Animal; Mass Spectrometry; Metabolic Networks and Pathways - physiology; Metabolome - physiology; Metabolomics; Mice; Mice, Inbred C57BL; Nitric oxide; Nitrosamines - metabolism; Purine Nucleotides - metabolism; Pyrimidines - metabolism; Retinal degeneration; Retinitis Pigmentosa - metabolism; UPLC-TOF-MS; Retinal degeneration; UPLC-TOF-MS; Metabolomics; Deoxynucleotide; Nitric oxide

Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. In the present report, we utilized broad spectrum metabolo...