Broad spectrum metabolomics for detection of abnormal metabolic pathways in a mouse model for retinitis pigmentosa
Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. In the present report, we utilized broad spectrum metabolo...
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Published in | Experimental eye research Vol. 184; pp. 135 - 145 |
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Main Authors | , , , , , , |
Format | Journal Article |
Language | English |
Published |
England
Elsevier Ltd
01.07.2019
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Abstract | Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. In the present report, we utilized broad spectrum metabolomics to identify perturbations in the metabolism of the rd10 mouse, a genetic model for RP that contains a mutation in Pde6β. These data provide novel insights into mechanisms that are potentially critical for retinal degeneration. C57BL/6J and rd10 mice were raised in cyclic light followed by either light or dark adaptation at postnatal day (P) 18, an early stage in the degeneration process. Mice raised entirely in the dark until P18 were also evaluated. After euthanasia, retinas were removed and extracted for analysis by ultra-performance liquid chromatography-time of flight-mass spectrometry (UPLC-QTOF-MS). Compared to wild type mice, rd10 mice raised in cyclic light or in complete darkness demonstrate significant alterations in retinal pyrimidine and purine nucleotide metabolism, potentially disrupting deoxynucleotide pools necessary for mitochondrial DNA replication. Other metabolites that demonstrate significant increases are the Coenzyme A intermediate, 4′-phosphopantothenate, and acylcarnitines. The changes in these metabolites, identified for the first time in a model of RP, are highly likely to disrupt normal energy metabolism. High levels of nitrosoproline were also detected in rd10 retinas relative to those from wild type mice. These results suggest that nitrosative stress may be involved in retinal degeneration in this mouse model.
•First use of broad spectrum metabolomics to identify metabolic perturbations in a mouse model for retinitis pigmentosa.•Differences in metabolite profiles were identified between wild type and rd10 mice raised in cyclic light or in the dark.•Pathways found to be most affected involved purine and pyrimidine deoxynucleotides.•Elevated levels of nitrosoproline suggest NO plays an important role in the degeneration program in rd10 mice.•These studies provide novel insights into retinal degeneration pathways that may lead to novel drug development. |
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AbstractList | Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. In the present report, we utilized broad spectrum metabolomics to identify perturbations in the metabolism of the rd10 mouse, a genetic model for RP that contains a mutation in Pde6β. These data provide novel insights into mechanisms that are potentially critical for retinal degeneration. C57BL/6J and rd10 mice were raised in cyclic light followed by either light or dark adaptation at postnatal day (P) 18, an early stage in the degeneration process. Mice raised entirely in the dark until P18 were also evaluated. After euthanasia, retinas were removed and extracted for analysis by ultra-performance liquid chromatography-time of flight-mass spectrometry (UPLC-QTOF-MS). Compared to wild type mice, rd10 mice raised in cyclic light or in complete darkness demonstrate significant alterations in retinal pyrimidine and purine nucleotide metabolism, potentially disrupting deoxynucleotide pools necessary for mitochondrial DNA replication. Other metabolites that demonstrate significant increases are the Coenzyme A intermediate, 4'-phosphopantothenate, and acylcarnitines. The changes in these metabolites, identified for the first time in a model of RP, are highly likely to disrupt normal energy metabolism. High levels of nitrosoproline were also detected in rd10 retinas relative to those from wild type mice. These results suggest that nitrosative stress may be involved in retinal degeneration in this mouse model. Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. In the present report, we utilized broad spectrum metabolomics to identify perturbations in the metabolism of the rd10 mouse, a genetic model for RP that contains a mutation in Pde6β. These data provide novel insights into mechanisms that are potentially critical for retinal degeneration. C57BL/6J and rd10 mice were raised in cyclic light followed by either light or dark adaptation at postnatal day (P) 18, an early stage in the degeneration process. Mice raised entirely in the dark until P18 were also evaluated. After euthanasia, retinas were removed and extracted for analysis by ultra-performance liquid chromatography-time of flight-mass spectrometry (UPLC-QTOF-MS). Compared to wild type mice, rd10 mice raised in cyclic light or in complete darkness demonstrate significant alterations in retinal pyrimidine and purine nucleotide metabolism, potentially disrupting deoxynucleotide pools necessary for mitochondrial DNA replication. Other metabolites that demonstrate significant increases are the Coenzyme A intermediate, 4’-phosphopantothenate, and acylcarnitines. The changes in these metabolites, identified for the first time in a model of RP, are highly likely to disrupt normal energy metabolism. High levels of nitrosoproline were also detected in rd10 retinas relative to those from wild type mice. These results suggest that nitrosative stress may be involved in retinal degeneration in this mouse model. Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of this disease, for which, at present, there are no effective therapeutic strategies. In the present report, we utilized broad spectrum metabolomics to identify perturbations in the metabolism of the rd10 mouse, a genetic model for RP that contains a mutation in Pde6β. These data provide novel insights into mechanisms that are potentially critical for retinal degeneration. C57BL/6J and rd10 mice were raised in cyclic light followed by either light or dark adaptation at postnatal day (P) 18, an early stage in the degeneration process. Mice raised entirely in the dark until P18 were also evaluated. After euthanasia, retinas were removed and extracted for analysis by ultra-performance liquid chromatography-time of flight-mass spectrometry (UPLC-QTOF-MS). Compared to wild type mice, rd10 mice raised in cyclic light or in complete darkness demonstrate significant alterations in retinal pyrimidine and purine nucleotide metabolism, potentially disrupting deoxynucleotide pools necessary for mitochondrial DNA replication. Other metabolites that demonstrate significant increases are the Coenzyme A intermediate, 4′-phosphopantothenate, and acylcarnitines. The changes in these metabolites, identified for the first time in a model of RP, are highly likely to disrupt normal energy metabolism. High levels of nitrosoproline were also detected in rd10 retinas relative to those from wild type mice. These results suggest that nitrosative stress may be involved in retinal degeneration in this mouse model. •First use of broad spectrum metabolomics to identify metabolic perturbations in a mouse model for retinitis pigmentosa.•Differences in metabolite profiles were identified between wild type and rd10 mice raised in cyclic light or in the dark.•Pathways found to be most affected involved purine and pyrimidine deoxynucleotides.•Elevated levels of nitrosoproline suggest NO plays an important role in the degeneration program in rd10 mice.•These studies provide novel insights into retinal degeneration pathways that may lead to novel drug development. |
Author | Fennell, Timothy R. Xiong, Yubin McRitchie, Susan Carlson, James Weiss, Ellen R. Dhungana, Suraj Osawa, Shoji |
AuthorAffiliation | g Present address: Waters Corporation, Milford, MA a Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, NC f Nutrition Research Institute, The University of North Carolina at Chapel Hill, NC c The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC h Present address: LECO Corporation, St. Joseph, MI d Eastern Regional Comprehensive Metabolomics Resource Core, The University of North Carolina at Chapel Hill, Chapel Hill, NC b The Neuroscience Center, The University of North Carolina at Chapel Hill, NC e RTI International, 3040 Cornwallis Drive, Research Triangle Park, NC, 27709, USA |
AuthorAffiliation_xml | – name: d Eastern Regional Comprehensive Metabolomics Resource Core, The University of North Carolina at Chapel Hill, Chapel Hill, NC – name: f Nutrition Research Institute, The University of North Carolina at Chapel Hill, NC – name: b The Neuroscience Center, The University of North Carolina at Chapel Hill, NC – name: c The Lineberger Comprehensive Cancer Center, The University of North Carolina at Chapel Hill, NC – name: e RTI International, 3040 Cornwallis Drive, Research Triangle Park, NC, 27709, USA – name: h Present address: LECO Corporation, St. Joseph, MI – name: a Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, NC – name: g Present address: Waters Corporation, Milford, MA |
Author_xml | – sequence: 1 givenname: Ellen R. surname: Weiss fullname: Weiss, Ellen R. email: erweiss@med.unc.edu organization: Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, NC, USA – sequence: 2 givenname: Shoji surname: Osawa fullname: Osawa, Shoji organization: Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, NC, USA – sequence: 3 givenname: Yubin surname: Xiong fullname: Xiong, Yubin organization: Department of Cell Biology and Physiology, The University of North Carolina at Chapel Hill, NC, USA – sequence: 4 givenname: Suraj surname: Dhungana fullname: Dhungana, Suraj organization: Eastern Regional Comprehensive Metabolomics Resource Core, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA – sequence: 5 givenname: James surname: Carlson fullname: Carlson, James organization: Eastern Regional Comprehensive Metabolomics Resource Core, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA – sequence: 6 givenname: Susan surname: McRitchie fullname: McRitchie, Susan organization: Eastern Regional Comprehensive Metabolomics Resource Core, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA – sequence: 7 givenname: Timothy R. surname: Fennell fullname: Fennell, Timothy R. email: fennell@rti.org organization: Eastern Regional Comprehensive Metabolomics Resource Core, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA |
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Cites_doi | 10.1074/jbc.M411446200 10.1093/brain/awr245 10.1016/j.nmd.2010.03.017 10.1016/S0891-5849(02)01183-8 10.1111/febs.12304 10.1167/iovs.12-11451 10.1038/13508 10.1038/nprot.2011.335 10.1016/S0042-6989(01)00146-8 10.1038/nrcardio.2011.138 10.1007/s10545-014-9755-y 10.1002/cpbi.11 10.1139/o94-058 10.1007/978-1-4614-0631-0_18 10.1080/01677063.2017.1358268 10.1167/tvst.7.1.14 10.1016/j.ymgmr.2016.07.007 10.1167/iovs.07-1622 10.1371/journal.pone.0112142 10.1074/jbc.M117.788422 10.1016/j.cell.2015.05.002 10.1002/cne.21144 10.1371/journal.pone.0072737 10.1146/annurev-neuro-060909-153227 10.1016/j.bbrc.2003.12.034 10.2174/138161205774913255 10.1007/s13311-013-0177-6 10.1167/iovs.17-22734 10.1016/S0140-6736(06)69740-7 10.1073/pnas.1002471107 10.1021/ac103011b 10.1159/000479158 10.1016/j.brainres.2011.10.045 10.15252/emmm.201505040 10.18632/oncotarget.5614 10.2337/db14-0509 10.1016/j.visres.2006.11.020 10.1016/j.exer.2012.04.004 10.1074/jbc.M005359200 10.1523/JNEUROSCI.6432-11.2012 10.1074/jbc.M115.698985 10.1074/jbc.RA118.004459 10.1016/j.mrfmmm.2018.01.005 10.1586/ern.10.54 10.1002/glia.22477 10.1111/j.1749-6632.2002.tb04077.x 10.1073/pnas.1718792115 10.1093/carcin/23.9.1537 10.1096/fj.06-7977rev 10.1111/j.1471-4159.2008.05822.x 10.1021/pr060594q 10.1083/jcb.201511036 10.1016/0014-5793(94)00722-5 10.1073/pnas.0306706101 10.1016/j.cub.2008.10.029 10.1039/b604498k 10.1038/nrm3013 |
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References | Linton, Holzhausen, Babai, Song, Miyagishima, Stearns, Lindsay, Wei, Chertov, Peters, Caffe, Pluk, Seeliger, Tanimoto, Fong, Bolton, Kuok, Sweet, Bartoletti, Radu, Travis, Zagotta, Townes-Anderson, Parker, Van der Zee, Sampath, Sokolov, Thoreson, Hurley (bib36) 2010; 107 Osborn, Park, Parks, Burgess, Uppal, Lee, Jones, Brantley (bib43) 2013; 8 L'hirondel (bib35) 2002 Donovan, Carmody, Cotter (bib17) 2001; 276 Chang, Hawes, Pardue, German, Hurd, Davisson, Nusinowitz, Rengarajan, Boyd, Sidney, Phillips, Stewart, Chaudhury, Nickerson, Heckenlively, Boatright (bib11) 2007; 47 Samardzija, Wariwoda, Imsand, Huber, Heynen, Gubler, Grimm (bib50) 2012; 99 Sas, Karnovsky, Michailidis, Pennathur (bib52) 2015; 64 Kaur, Halliwell (bib34) 1994; 350 Liu, Gao, Wang, Jeohn, Cooper, Hong (bib37) 2002; 962 Chang, Hawes, Hurd, Davisson, Nusinowitz, Heckenlively (bib10) 2002; 42 Hartong, Berson, Dryja (bib30) 2006; 368 Xia, Wishart (bib64) 2016; 55 El-Hattab, Scaglia (bib21) 2013; 10 Reichenbach, Bringmann (bib48) 2013; 61 Westermann (bib61) 2010; 11 Dunn, Broadhurst, Begley, Zelena, Francis-McIntyre, Anderson, Brown, Knowles, Halsall, Haselden, Nicholls, Wilson, Kell, Goodacre (bib20) 2011; 6 Aicardo, Martinez, Campolo, Bartesaghi, Radi (bib2) 2016 Macosko, Basu, Satija, Nemesh, Shekhar, Goldman, Tirosh, Bialas, Kamitaki, Martersteck, Trombetta, Weitz, Sanes, Shalek, Regev, McCarroll (bib38) 2015; 161 Trygg, Holmes, Lundstedt (bib56) 2007; 6 Eriksson, Byrne, Johansson, Trygg, Vikström (bib22) 2013 Williamson, Hawkey, Blake, Frenkel, McDaniel, Davis, Satija, Beazer, Dhungana, Carlson, McRitchie, Ayyala (bib62) 2018; 7 Arango-Gonzalez, Trifunovic, Sahaboglu, Kranz, Michalakis, Farinelli, Koch, Koch, Cottet, Janssen-Bienhold, Dedek, Biel, Zrenner, Euler, Ekstrom, Ueffing, Paquet-Durand (bib3) 2014; 9 Garone, Tadesse, Hirano (bib26) 2011; 134 Rassaf, Bryan, Kelm, Feelisch (bib47) 2002; 33 Perraud, Takanishi, Shen, Kang, Smith, Schmitz, Knowles, Ferraris, Li, Zhang, Stoddard, Scharenberg (bib46) 2005; 280 Griffin, Atherton, Shockcor, Atzori (bib28) 2011; 8 Mishra, Chan (bib41) 2016; 212 Du, Rountree, Cleghorn, Contreras, Lindsay, Sadilek, Gu, Djukovic, Raftery, Satrustegui, Kanow, Chan, Tsang, Sweet, Hurley (bib19) 2016; 291 Han, Dinculescu, Dai, Du, Smith, Pang (bib29) 2013; 19 Pang, Boye, Kumar, Dinculescu, Deng, Li, Li, Rani, Foster, Chang, Hawes, Boatright, Hauswirth (bib44) 2008; 49 Dong, Bachleda, Xiong, Osawa, Weiss (bib16) 2017; 23 Wong, Borst, Farber, Danciger, Tenniswood, Chader, van Veen (bib63) 1994; 72 Caudle, Bammler, Lin, Pan, Zhang (bib9) 2010; 10 Okawa, Sampath, Laughlin, Fain (bib42) 2008; 18 Kam, Jeffery (bib33) 2015; 6 Berkowitz, Podolsky, Berri, Dernay, Graffice, Shafie-Khorassani, Roberts (bib6) 2018; 59 Di Meo, Lamperti, Tiranti (bib14) 2015; 7 Cronin, Lyubarsky, Bennett (bib13) 2012; 723 Agudo-Barriuso, Lahoz, Nadal-Nicolas, Sobrado-Calvo, Piquer-Gil, Diaz-Llopis, Vidal-Sanz, Mullor (bib1) 2013; 54 Ricchetti (bib49) 2018; 808 Sangster, Major, Plumb, Wilson, Wilson (bib51) 2006; 131 Mathews, Song (bib40) 2007; 21 Paquet-Durand, Hauck, van Veen, Ueffing, Ekstrom (bib45) 2009; 108 Frasson, Sahel, Fabre, Simonutti, Dreyfus, Picaud (bib24) 1999; 5 Chao, Knight, Engel, Jankowski, Wang, Manson, Gu, Djukovic, Raftery, Hurley, Du (bib12) 2017; 292 Bryan, Rassaf, Maloney, Rodriguez, Saijo, Rodriguez, Feelisch (bib8) 2004; 101 Wei, Schubert, Paquet-Durand, Tanimoto, Chang, Koeppen, Ott, Griesbeck, Seeliger, Euler, Wissinger (bib60) 2012; 32 Dolle, Rack, Ziegler (bib15) 2013; 280 Ferrier (bib23) 2014 Wang, Reingruber, Woodruff, Majumder, Camarena, Artemyev, Fain, Chen (bib59) 2018; 293 Jurecka, Zikanova, Kmoch, Tylki-Szymanska (bib32) 2015; 38 Masson, Spagou, Nicholson, Want (bib39) 2011; 83 Arimoto-Kobayashi, Ando, Horai, Okamoto, Hayatsu, Lowe, Green (bib4) 2002; 23 Barbosa-Breda, Himmelreich, Ghesquiere, Rocha-Sousa, Stalmans (bib5) 2018; 59 Donti, Cappuccio, Hubert, Neira, Atwal, Miller, Cardon, Sutton, Porter, Baumer, Wangler, Sun, Emrick, Elsea (bib18) 2016; 8 Suomalainen, Isohanni (bib53) 2010; 20 Thomas, Ridnour, Donzelli, Espey, Mancardi, Isenberg, Feelisch, Roberts, Wink (bib55) 2006 Bramall, Wright, Jacobson, McInnes (bib7) 2010; 33 Iribarne, Masai (bib31) 2017; 31 Vielma, Retamal, Schmachtenberg (bib57) 2012; 1430 Takano, Ohguro, Dezawa, Ishikawa, Yamazaki, Ohguro, Mamiya, Metoki, Ishikawa, Nakazawa (bib54) 2004; 313 Vighi, Trifunovic, Veiga-Crespo, Rentsch, Hoffmann, Sahaboglu, Strasser, Kulkarni, Bertolotti, van den Heuvel, Peters, Reijerkerk, Euler, Ueffing, Schwede, Genieser, Gaillard, Marigo, Ekstrom, Paquet-Durand (bib58) 2018; 115 Glantzounis, Tsimoyiannis, Kappas, Galaris (bib27) 2005; 11 Gargini, Terzibasi, Mazzoni, Strettoi (bib25) 2007; 500 Ferrier (10.1016/j.exer.2019.03.007_bib23) 2014 Takano (10.1016/j.exer.2019.03.007_bib54) 2004; 313 Chang (10.1016/j.exer.2019.03.007_bib10) 2002; 42 Masson (10.1016/j.exer.2019.03.007_bib39) 2011; 83 El-Hattab (10.1016/j.exer.2019.03.007_bib21) 2013; 10 Gargini (10.1016/j.exer.2019.03.007_bib25) 2007; 500 Linton (10.1016/j.exer.2019.03.007_bib36) 2010; 107 Vighi (10.1016/j.exer.2019.03.007_bib58) 2018; 115 Mathews (10.1016/j.exer.2019.03.007_bib40) 2007; 21 Pang (10.1016/j.exer.2019.03.007_bib44) 2008; 49 Thomas (10.1016/j.exer.2019.03.007_bib55) 2006 Jurecka (10.1016/j.exer.2019.03.007_bib32) 2015; 38 Iribarne (10.1016/j.exer.2019.03.007_bib31) 2017; 31 Reichenbach (10.1016/j.exer.2019.03.007_bib48) 2013; 61 Suomalainen (10.1016/j.exer.2019.03.007_bib53) 2010; 20 Arimoto-Kobayashi (10.1016/j.exer.2019.03.007_bib4) 2002; 23 Eriksson (10.1016/j.exer.2019.03.007_bib22) 2013 Glantzounis (10.1016/j.exer.2019.03.007_bib27) 2005; 11 Cronin (10.1016/j.exer.2019.03.007_bib13) 2012; 723 Frasson (10.1016/j.exer.2019.03.007_bib24) 1999; 5 Samardzija (10.1016/j.exer.2019.03.007_bib50) 2012; 99 Bryan (10.1016/j.exer.2019.03.007_bib8) 2004; 101 Macosko (10.1016/j.exer.2019.03.007_bib38) 2015; 161 Chang (10.1016/j.exer.2019.03.007_bib11) 2007; 47 Dolle (10.1016/j.exer.2019.03.007_bib15) 2013; 280 Wang (10.1016/j.exer.2019.03.007_bib59) 2018; 293 L'hirondel (10.1016/j.exer.2019.03.007_bib35) 2002 Xia (10.1016/j.exer.2019.03.007_bib64) 2016; 55 Okawa (10.1016/j.exer.2019.03.007_bib42) 2008; 18 Kaur (10.1016/j.exer.2019.03.007_bib34) 1994; 350 Barbosa-Breda (10.1016/j.exer.2019.03.007_bib5) 2018; 59 Wong (10.1016/j.exer.2019.03.007_bib63) 1994; 72 Berkowitz (10.1016/j.exer.2019.03.007_bib6) 2018; 59 Williamson (10.1016/j.exer.2019.03.007_bib62) 2018; 7 Du (10.1016/j.exer.2019.03.007_bib19) 2016; 291 Westermann (10.1016/j.exer.2019.03.007_bib61) 2010; 11 Vielma (10.1016/j.exer.2019.03.007_bib57) 2012; 1430 Kam (10.1016/j.exer.2019.03.007_bib33) 2015; 6 Wei (10.1016/j.exer.2019.03.007_bib60) 2012; 32 Arango-Gonzalez (10.1016/j.exer.2019.03.007_bib3) 2014; 9 Dunn (10.1016/j.exer.2019.03.007_bib20) 2011; 6 Perraud (10.1016/j.exer.2019.03.007_bib46) 2005; 280 Griffin (10.1016/j.exer.2019.03.007_bib28) 2011; 8 Ricchetti (10.1016/j.exer.2019.03.007_bib49) 2018; 808 Garone (10.1016/j.exer.2019.03.007_bib26) 2011; 134 Hartong (10.1016/j.exer.2019.03.007_bib30) 2006; 368 Aicardo (10.1016/j.exer.2019.03.007_bib2) 2016 Han (10.1016/j.exer.2019.03.007_bib29) 2013; 19 Caudle (10.1016/j.exer.2019.03.007_bib9) 2010; 10 Chao (10.1016/j.exer.2019.03.007_bib12) 2017; 292 Paquet-Durand (10.1016/j.exer.2019.03.007_bib45) 2009; 108 Dong (10.1016/j.exer.2019.03.007_bib16) 2017; 23 Donovan (10.1016/j.exer.2019.03.007_bib17) 2001; 276 Di Meo (10.1016/j.exer.2019.03.007_bib14) 2015; 7 Agudo-Barriuso (10.1016/j.exer.2019.03.007_bib1) 2013; 54 Osborn (10.1016/j.exer.2019.03.007_bib43) 2013; 8 Sangster (10.1016/j.exer.2019.03.007_bib51) 2006; 131 Bramall (10.1016/j.exer.2019.03.007_bib7) 2010; 33 Mishra (10.1016/j.exer.2019.03.007_bib41) 2016; 212 Sas (10.1016/j.exer.2019.03.007_bib52) 2015; 64 Trygg (10.1016/j.exer.2019.03.007_bib56) 2007; 6 Liu (10.1016/j.exer.2019.03.007_bib37) 2002; 962 Rassaf (10.1016/j.exer.2019.03.007_bib47) 2002; 33 Donti (10.1016/j.exer.2019.03.007_bib18) 2016; 8 |
References_xml | – volume: 10 start-page: 925 year: 2010 end-page: 942 ident: bib9 article-title: Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease publication-title: Expert Rev. Neurother. contributor: fullname: Zhang – volume: 11 start-page: 4145 year: 2005 end-page: 4151 ident: bib27 article-title: Uric acid and oxidative stress publication-title: Curr. Pharmaceut. Des. contributor: fullname: Galaris – volume: 64 start-page: 718 year: 2015 end-page: 732 ident: bib52 article-title: Metabolomics and diabetes: analytical and computational approaches publication-title: Diabetes contributor: fullname: Pennathur – volume: 1430 start-page: 112 year: 2012 end-page: 125 ident: bib57 article-title: Nitric oxide signaling in the retina: what have we learned in two decades? publication-title: Brain Res. contributor: fullname: Schmachtenberg – volume: 161 start-page: 1202 year: 2015 end-page: 1214 ident: bib38 article-title: Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets publication-title: Cell contributor: fullname: McCarroll – volume: 293 start-page: 15332 year: 2018 end-page: 15346 ident: bib59 article-title: The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx publication-title: J. Biol. Chem. contributor: fullname: Chen – volume: 7 start-page: 14 year: 2018 ident: bib62 article-title: The effects of glaucoma drainage devices on oxygen tension, glycolytic metabolites, and metabolomics profile of aqueous humor in the rabbit publication-title: Transl. Vis. Sci. Technol. contributor: fullname: Ayyala – volume: 33 start-page: 1590 year: 2002 end-page: 1596 ident: bib47 article-title: Concomitant presence of N-nitroso and S-nitroso proteins in human plasma publication-title: Free Radic. Biol. Med. contributor: fullname: Feelisch – volume: 19 start-page: 2579 year: 2013 end-page: 2589 ident: bib29 article-title: Review: the history and role of naturally occurring mouse models with Pde6b mutations publication-title: Mol. Vis. contributor: fullname: Pang – volume: 99 start-page: 17 year: 2012 end-page: 26 ident: bib50 article-title: Activation of survival pathways in the degenerating retina of publication-title: Exp. Eye Res. contributor: fullname: Grimm – volume: 280 start-page: 6138 year: 2005 end-page: 6148 ident: bib46 article-title: Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels publication-title: J. Biol. Chem. contributor: fullname: Scharenberg – volume: 61 start-page: 651 year: 2013 end-page: 678 ident: bib48 article-title: New functions of Müller cells publication-title: Glia contributor: fullname: Bringmann – volume: 292 start-page: 12895 year: 2017 end-page: 12905 ident: bib12 article-title: Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side publication-title: J. Biol. Chem. contributor: fullname: Du – volume: 962 start-page: 318 year: 2002 end-page: 331 ident: bib37 article-title: Role of nitric oxide in inflammation-mediated neurodegeneration publication-title: Ann. N. Y. Acad. Sci. contributor: fullname: Hong – volume: 6 start-page: 26690 year: 2015 end-page: 26701 ident: bib33 article-title: To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss publication-title: Oncotarget contributor: fullname: Jeffery – volume: 276 start-page: 23000 year: 2001 end-page: 23008 ident: bib17 article-title: Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent publication-title: J. Biol. Chem. contributor: fullname: Cotter – volume: 291 start-page: 4698 year: 2016 end-page: 4710 ident: bib19 article-title: Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina publication-title: J. Biol. Chem. contributor: fullname: Hurley – volume: 107 start-page: 8599 year: 2010 end-page: 8604 ident: bib36 article-title: Flow of energy in the outer retina in darkness and in light publication-title: Proc. Natl. Acad. Sci. U.S.A. contributor: fullname: Hurley – volume: 21 start-page: 2294 year: 2007 end-page: 2303 ident: bib40 article-title: Maintaining precursor pools for mitochondrial DNA replication publication-title: J contributor: fullname: Song – volume: 808 start-page: 93 year: 2018 end-page: 102 ident: bib49 article-title: Replication stress in mitochondria publication-title: Mutat. Res. contributor: fullname: Ricchetti – volume: 10 start-page: 186 year: 2013 end-page: 198 ident: bib21 article-title: Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options publication-title: Neurotherapeutics contributor: fullname: Scaglia – year: 2014 ident: bib23 article-title: Biochemistry contributor: fullname: Ferrier – volume: 134 start-page: 3326 year: 2011 end-page: 3332 ident: bib26 article-title: Clinical and genetic spectrum of mitochondrial neurogastrointestinal encephalomyopathy publication-title: Brain contributor: fullname: Hirano – volume: 55 start-page: 14 year: 2016 ident: bib64 article-title: Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis publication-title: Curr. Protoc. in Bioinformatics contributor: fullname: Wishart – volume: 72 start-page: 439 year: 1994 end-page: 446 ident: bib63 article-title: Increased TRPM-2/clusterin mRNA levels during the time of retinal degeneration in mouse models of retinitis pigmentosa publication-title: Biochem. Cell Biol. contributor: fullname: van Veen – volume: 313 start-page: 1015 year: 2004 end-page: 1022 ident: bib54 article-title: Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse publication-title: Biochem. Biophys. Res. Commun. contributor: fullname: Nakazawa – volume: 33 start-page: 441 year: 2010 end-page: 472 ident: bib7 article-title: The genomic, biochemical, and cellular responses of the retina in inherited photoreceptor degenerations and prospects for the treatment of these disorders publication-title: Annu. Rev. Neurosci. contributor: fullname: McInnes – volume: 723 start-page: 129 year: 2012 end-page: 136 ident: bib13 article-title: Dark-rearing the publication-title: Adv. Exp. Med. Biol. contributor: fullname: Bennett – volume: 18 start-page: 1917 year: 2008 end-page: 1921 ident: bib42 article-title: ATP consumption by mammalian rod photoreceptors in darkness and in light publication-title: Curr. Biol. contributor: fullname: Fain – start-page: 25 year: 2006 end-page: 50 ident: bib55 article-title: The chemistry of protein modifications elicited by nitric oxide and related nitrogen oxides publication-title: Redox Proteomics: from Protein Modifications to Cellular Dysfunction and Diseases contributor: fullname: Wink – volume: 5 start-page: 1183 year: 1999 end-page: 1187 ident: bib24 article-title: Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the publication-title: Nat. Med. contributor: fullname: Picaud – start-page: 49 year: 2016 end-page: 77 ident: bib2 article-title: Biochemistry of nitric oxide and peroxynitrite: sources, targets and biological implications publication-title: Biochemistry of Oxidative Stress contributor: fullname: Radi – volume: 280 start-page: 3530 year: 2013 end-page: 3541 ident: bib15 article-title: NAD and ADP-ribose metabolism in mitochondria publication-title: FEBS J. contributor: fullname: Ziegler – volume: 108 start-page: 796 year: 2009 end-page: 810 ident: bib45 article-title: PKG activity causes photoreceptor cell death in two retinitis pigmentosa models publication-title: J. Neurochem. contributor: fullname: Ekstrom – start-page: 35 year: 2002 end-page: 68 ident: bib35 article-title: The Case against Nitrate: a Critical Examination, Nitrate and Man: Toxic, Harmless or Beneficial? contributor: fullname: L'hirondel – volume: 500 start-page: 222 year: 2007 end-page: 238 ident: bib25 article-title: Retinal organization in the retinal degeneration 10 ( publication-title: J. Comp. Neurol. contributor: fullname: Strettoi – year: 2013 ident: bib22 article-title: Multi- and Megavariate Data Analysis: Basic Principles and Applications contributor: fullname: Vikström – volume: 8 year: 2013 ident: bib43 article-title: Metabolome-wide association study of neovascular age-related macular degeneration publication-title: PLoS One contributor: fullname: Brantley – volume: 9 year: 2014 ident: bib3 article-title: Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration publication-title: PLoS One contributor: fullname: Paquet-Durand – volume: 54 start-page: 4249 year: 2013 end-page: 4259 ident: bib1 article-title: Metabolomic changes in the rat retina after optic nerve crush publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Mullor – volume: 6 start-page: 469 year: 2007 end-page: 479 ident: bib56 article-title: Chemometrics in metabonomics publication-title: J. Proteome Res. contributor: fullname: Lundstedt – volume: 8 start-page: 630 year: 2011 end-page: 643 ident: bib28 article-title: Metabolomics as a tool for cardiac research publication-title: Nat. Rev. Cardiol. contributor: fullname: Atzori – volume: 131 start-page: 1075 year: 2006 end-page: 1078 ident: bib51 article-title: A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis publication-title: Analyst contributor: fullname: Wilson – volume: 38 start-page: 231 year: 2015 end-page: 242 ident: bib32 article-title: Adenylosuccinate lyase deficiency publication-title: J. Inherit. Metab. Dis. contributor: fullname: Tylki-Szymanska – volume: 59 start-page: 1659 year: 2018 end-page: 1665 ident: bib6 article-title: Dark rearing does not prevent rod oxidative stress in vivo in pde6b(rd10) mice publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Roberts – volume: 20 start-page: 429 year: 2010 end-page: 437 ident: bib53 article-title: Mitochondrial DNA depletion syndromes--many genes, common mechanisms publication-title: Neuromuscul. Disord. : NMD contributor: fullname: Isohanni – volume: 32 start-page: 6981 year: 2012 end-page: 6994 ident: bib60 article-title: Light-driven calcium signals in mouse cone photoreceptors publication-title: J. Neurosci. contributor: fullname: Wissinger – volume: 115 start-page: E2997 year: 2018 end-page: E3006 ident: bib58 article-title: Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Paquet-Durand – volume: 47 start-page: 624 year: 2007 end-page: 633 ident: bib11 article-title: Two mouse retinal degenerations caused by missense mutations in the β subunit of rod cGMP phosphodiesterase gene publication-title: Vision Res. contributor: fullname: Boatright – volume: 42 start-page: 517 year: 2002 end-page: 525 ident: bib10 article-title: Retinal degeneration mutants in the mouse publication-title: Vision Res. contributor: fullname: Heckenlively – volume: 8 start-page: 61 year: 2016 end-page: 66 ident: bib18 article-title: Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum publication-title: Mol. Genet. Metab. Rep. contributor: fullname: Elsea – volume: 83 start-page: 1116 year: 2011 end-page: 1123 ident: bib39 article-title: Technical and biological variation in UPLC-MS-based untargeted metabolic profiling of liver extracts: application in an experimental toxicity study on galactosamine publication-title: Anal. Chem. contributor: fullname: Want – volume: 7 start-page: 1257 year: 2015 end-page: 1266 ident: bib14 article-title: Mitochondrial diseases caused by toxic compound accumulation: from etiopathology to therapeutic approaches publication-title: EMBO Mol. Med. contributor: fullname: Tiranti – volume: 23 start-page: 1537 year: 2002 end-page: 1540 ident: bib4 article-title: Mutation, DNA strand cleavage and nitric oxide formation caused by N-nitrosoproline with sunlight: a possible mechanism of UVA carcinogenicity publication-title: Carcinogenesis contributor: fullname: Green – volume: 101 start-page: 4308 year: 2004 end-page: 4313 ident: bib8 article-title: Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo publication-title: Proc. Natl. Acad. Sci. U. S. A. contributor: fullname: Feelisch – volume: 59 start-page: 1 year: 2018 end-page: 6 ident: bib5 article-title: Clinical metabolomics and glaucoma publication-title: Ophthalmic Res. contributor: fullname: Stalmans – volume: 31 start-page: 88 year: 2017 end-page: 101 ident: bib31 article-title: Neurotoxicity of cGMP in the vertebrate retina: from the initial research on publication-title: J. Neurogenet. contributor: fullname: Masai – volume: 6 start-page: 1060 year: 2011 end-page: 1083 ident: bib20 article-title: Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry publication-title: Nat. Protoc. contributor: fullname: Goodacre – volume: 212 start-page: 379 year: 2016 end-page: 387 ident: bib41 article-title: Metabolic regulation of mitochondrial dynamics publication-title: J. Cell Biol. contributor: fullname: Chan – volume: 23 start-page: 90 year: 2017 end-page: 102 ident: bib16 article-title: Reduced phosphoCREB in Müller glia during retinal degeneration in publication-title: Mol. Vis. contributor: fullname: Weiss – volume: 11 start-page: 872 year: 2010 end-page: 884 ident: bib61 article-title: Mitochondrial fusion and fission in cell life and death publication-title: Nat. Rev. Mol. Cell Biol. contributor: fullname: Westermann – volume: 368 start-page: 1795 year: 2006 end-page: 1809 ident: bib30 article-title: Retinitis pigmentosa publication-title: Lancet contributor: fullname: Dryja – volume: 49 start-page: 4278 year: 2008 end-page: 4283 ident: bib44 article-title: AAV-mediated gene therapy for retinal degeneration in the publication-title: Invest. Ophthalmol. Vis. Sci. contributor: fullname: Hauswirth – volume: 350 start-page: 9 year: 1994 end-page: 12 ident: bib34 article-title: Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients publication-title: FEBS Lett. contributor: fullname: Halliwell – volume: 280 start-page: 6138 year: 2005 ident: 10.1016/j.exer.2019.03.007_bib46 article-title: Accumulation of free ADP-ribose from mitochondria mediates oxidative stress-induced gating of TRPM2 cation channels publication-title: J. Biol. Chem. doi: 10.1074/jbc.M411446200 contributor: fullname: Perraud – volume: 134 start-page: 3326 year: 2011 ident: 10.1016/j.exer.2019.03.007_bib26 article-title: Clinical and genetic spectrum of mitochondrial neurogastrointestinal encephalomyopathy publication-title: Brain doi: 10.1093/brain/awr245 contributor: fullname: Garone – volume: 20 start-page: 429 year: 2010 ident: 10.1016/j.exer.2019.03.007_bib53 article-title: Mitochondrial DNA depletion syndromes--many genes, common mechanisms publication-title: Neuromuscul. Disord. : NMD doi: 10.1016/j.nmd.2010.03.017 contributor: fullname: Suomalainen – volume: 33 start-page: 1590 year: 2002 ident: 10.1016/j.exer.2019.03.007_bib47 article-title: Concomitant presence of N-nitroso and S-nitroso proteins in human plasma publication-title: Free Radic. Biol. Med. doi: 10.1016/S0891-5849(02)01183-8 contributor: fullname: Rassaf – volume: 280 start-page: 3530 year: 2013 ident: 10.1016/j.exer.2019.03.007_bib15 article-title: NAD and ADP-ribose metabolism in mitochondria publication-title: FEBS J. doi: 10.1111/febs.12304 contributor: fullname: Dolle – volume: 54 start-page: 4249 year: 2013 ident: 10.1016/j.exer.2019.03.007_bib1 article-title: Metabolomic changes in the rat retina after optic nerve crush publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.12-11451 contributor: fullname: Agudo-Barriuso – volume: 5 start-page: 1183 year: 1999 ident: 10.1016/j.exer.2019.03.007_bib24 article-title: Retinitis pigmentosa: rod photoreceptor rescue by a calcium-channel blocker in the rd mouse publication-title: Nat. Med. doi: 10.1038/13508 contributor: fullname: Frasson – volume: 6 start-page: 1060 year: 2011 ident: 10.1016/j.exer.2019.03.007_bib20 article-title: Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry publication-title: Nat. Protoc. doi: 10.1038/nprot.2011.335 contributor: fullname: Dunn – year: 2013 ident: 10.1016/j.exer.2019.03.007_bib22 contributor: fullname: Eriksson – volume: 23 start-page: 90 year: 2017 ident: 10.1016/j.exer.2019.03.007_bib16 article-title: Reduced phosphoCREB in Müller glia during retinal degeneration in rd10 mice publication-title: Mol. Vis. contributor: fullname: Dong – volume: 42 start-page: 517 year: 2002 ident: 10.1016/j.exer.2019.03.007_bib10 article-title: Retinal degeneration mutants in the mouse publication-title: Vision Res. doi: 10.1016/S0042-6989(01)00146-8 contributor: fullname: Chang – volume: 8 start-page: 630 year: 2011 ident: 10.1016/j.exer.2019.03.007_bib28 article-title: Metabolomics as a tool for cardiac research publication-title: Nat. Rev. Cardiol. doi: 10.1038/nrcardio.2011.138 contributor: fullname: Griffin – volume: 38 start-page: 231 year: 2015 ident: 10.1016/j.exer.2019.03.007_bib32 article-title: Adenylosuccinate lyase deficiency publication-title: J. Inherit. Metab. Dis. doi: 10.1007/s10545-014-9755-y contributor: fullname: Jurecka – volume: 55 start-page: 14 year: 2016 ident: 10.1016/j.exer.2019.03.007_bib64 article-title: Using MetaboAnalyst 3.0 for comprehensive metabolomics data analysis publication-title: Curr. Protoc. in Bioinformatics doi: 10.1002/cpbi.11 contributor: fullname: Xia – start-page: 49 year: 2016 ident: 10.1016/j.exer.2019.03.007_bib2 article-title: Biochemistry of nitric oxide and peroxynitrite: sources, targets and biological implications contributor: fullname: Aicardo – volume: 72 start-page: 439 year: 1994 ident: 10.1016/j.exer.2019.03.007_bib63 article-title: Increased TRPM-2/clusterin mRNA levels during the time of retinal degeneration in mouse models of retinitis pigmentosa publication-title: Biochem. Cell Biol. doi: 10.1139/o94-058 contributor: fullname: Wong – volume: 723 start-page: 129 year: 2012 ident: 10.1016/j.exer.2019.03.007_bib13 article-title: Dark-rearing the rd10 mouse: implications for therapy publication-title: Adv. Exp. Med. Biol. doi: 10.1007/978-1-4614-0631-0_18 contributor: fullname: Cronin – volume: 31 start-page: 88 year: 2017 ident: 10.1016/j.exer.2019.03.007_bib31 article-title: Neurotoxicity of cGMP in the vertebrate retina: from the initial research on rd mutant mice to zebrafish genetic approaches publication-title: J. Neurogenet. doi: 10.1080/01677063.2017.1358268 contributor: fullname: Iribarne – volume: 7 start-page: 14 year: 2018 ident: 10.1016/j.exer.2019.03.007_bib62 article-title: The effects of glaucoma drainage devices on oxygen tension, glycolytic metabolites, and metabolomics profile of aqueous humor in the rabbit publication-title: Transl. Vis. Sci. Technol. doi: 10.1167/tvst.7.1.14 contributor: fullname: Williamson – volume: 8 start-page: 61 year: 2016 ident: 10.1016/j.exer.2019.03.007_bib18 article-title: Diagnosis of adenylosuccinate lyase deficiency by metabolomic profiling in plasma reveals a phenotypic spectrum publication-title: Mol. Genet. Metab. Rep. doi: 10.1016/j.ymgmr.2016.07.007 contributor: fullname: Donti – volume: 49 start-page: 4278 year: 2008 ident: 10.1016/j.exer.2019.03.007_bib44 article-title: AAV-mediated gene therapy for retinal degeneration in the rd10 mouse containing a recessive PDEbeta mutation publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.07-1622 contributor: fullname: Pang – volume: 9 year: 2014 ident: 10.1016/j.exer.2019.03.007_bib3 article-title: Identification of a common non-apoptotic cell death mechanism in hereditary retinal degeneration publication-title: PLoS One doi: 10.1371/journal.pone.0112142 contributor: fullname: Arango-Gonzalez – volume: 292 start-page: 12895 year: 2017 ident: 10.1016/j.exer.2019.03.007_bib12 article-title: Human retinal pigment epithelial cells prefer proline as a nutrient and transport metabolic intermediates to the retinal side publication-title: J. Biol. Chem. doi: 10.1074/jbc.M117.788422 contributor: fullname: Chao – volume: 161 start-page: 1202 year: 2015 ident: 10.1016/j.exer.2019.03.007_bib38 article-title: Highly parallel genome-wide expression profiling of individual cells using nanoliter droplets publication-title: Cell doi: 10.1016/j.cell.2015.05.002 contributor: fullname: Macosko – volume: 500 start-page: 222 year: 2007 ident: 10.1016/j.exer.2019.03.007_bib25 article-title: Retinal organization in the retinal degeneration 10 (rd10) mutant mouse: a morphological and ERG study publication-title: J. Comp. Neurol. doi: 10.1002/cne.21144 contributor: fullname: Gargini – volume: 8 year: 2013 ident: 10.1016/j.exer.2019.03.007_bib43 article-title: Metabolome-wide association study of neovascular age-related macular degeneration publication-title: PLoS One doi: 10.1371/journal.pone.0072737 contributor: fullname: Osborn – volume: 33 start-page: 441 year: 2010 ident: 10.1016/j.exer.2019.03.007_bib7 article-title: The genomic, biochemical, and cellular responses of the retina in inherited photoreceptor degenerations and prospects for the treatment of these disorders publication-title: Annu. Rev. Neurosci. doi: 10.1146/annurev-neuro-060909-153227 contributor: fullname: Bramall – volume: 313 start-page: 1015 year: 2004 ident: 10.1016/j.exer.2019.03.007_bib54 article-title: Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse publication-title: Biochem. Biophys. Res. Commun. doi: 10.1016/j.bbrc.2003.12.034 contributor: fullname: Takano – start-page: 25 year: 2006 ident: 10.1016/j.exer.2019.03.007_bib55 article-title: The chemistry of protein modifications elicited by nitric oxide and related nitrogen oxides contributor: fullname: Thomas – volume: 11 start-page: 4145 year: 2005 ident: 10.1016/j.exer.2019.03.007_bib27 article-title: Uric acid and oxidative stress publication-title: Curr. Pharmaceut. Des. doi: 10.2174/138161205774913255 contributor: fullname: Glantzounis – volume: 10 start-page: 186 year: 2013 ident: 10.1016/j.exer.2019.03.007_bib21 article-title: Mitochondrial DNA depletion syndromes: review and updates of genetic basis, manifestations, and therapeutic options publication-title: Neurotherapeutics doi: 10.1007/s13311-013-0177-6 contributor: fullname: El-Hattab – volume: 59 start-page: 1659 year: 2018 ident: 10.1016/j.exer.2019.03.007_bib6 article-title: Dark rearing does not prevent rod oxidative stress in vivo in pde6b(rd10) mice publication-title: Invest. Ophthalmol. Vis. Sci. doi: 10.1167/iovs.17-22734 contributor: fullname: Berkowitz – volume: 368 start-page: 1795 year: 2006 ident: 10.1016/j.exer.2019.03.007_bib30 article-title: Retinitis pigmentosa publication-title: Lancet doi: 10.1016/S0140-6736(06)69740-7 contributor: fullname: Hartong – volume: 107 start-page: 8599 year: 2010 ident: 10.1016/j.exer.2019.03.007_bib36 article-title: Flow of energy in the outer retina in darkness and in light publication-title: Proc. Natl. Acad. Sci. U.S.A. doi: 10.1073/pnas.1002471107 contributor: fullname: Linton – volume: 83 start-page: 1116 year: 2011 ident: 10.1016/j.exer.2019.03.007_bib39 article-title: Technical and biological variation in UPLC-MS-based untargeted metabolic profiling of liver extracts: application in an experimental toxicity study on galactosamine publication-title: Anal. Chem. doi: 10.1021/ac103011b contributor: fullname: Masson – volume: 59 start-page: 1 year: 2018 ident: 10.1016/j.exer.2019.03.007_bib5 article-title: Clinical metabolomics and glaucoma publication-title: Ophthalmic Res. doi: 10.1159/000479158 contributor: fullname: Barbosa-Breda – start-page: 35 year: 2002 ident: 10.1016/j.exer.2019.03.007_bib35 contributor: fullname: L'hirondel – volume: 1430 start-page: 112 year: 2012 ident: 10.1016/j.exer.2019.03.007_bib57 article-title: Nitric oxide signaling in the retina: what have we learned in two decades? publication-title: Brain Res. doi: 10.1016/j.brainres.2011.10.045 contributor: fullname: Vielma – volume: 7 start-page: 1257 year: 2015 ident: 10.1016/j.exer.2019.03.007_bib14 article-title: Mitochondrial diseases caused by toxic compound accumulation: from etiopathology to therapeutic approaches publication-title: EMBO Mol. Med. doi: 10.15252/emmm.201505040 contributor: fullname: Di Meo – volume: 6 start-page: 26690 year: 2015 ident: 10.1016/j.exer.2019.03.007_bib33 article-title: To unite or divide: mitochondrial dynamics in the murine outer retina that preceded age related photoreceptor loss publication-title: Oncotarget doi: 10.18632/oncotarget.5614 contributor: fullname: Kam – volume: 64 start-page: 718 year: 2015 ident: 10.1016/j.exer.2019.03.007_bib52 article-title: Metabolomics and diabetes: analytical and computational approaches publication-title: Diabetes doi: 10.2337/db14-0509 contributor: fullname: Sas – volume: 47 start-page: 624 year: 2007 ident: 10.1016/j.exer.2019.03.007_bib11 article-title: Two mouse retinal degenerations caused by missense mutations in the β subunit of rod cGMP phosphodiesterase gene publication-title: Vision Res. doi: 10.1016/j.visres.2006.11.020 contributor: fullname: Chang – volume: 99 start-page: 17 year: 2012 ident: 10.1016/j.exer.2019.03.007_bib50 article-title: Activation of survival pathways in the degenerating retina of rd10 mice publication-title: Exp. Eye Res. doi: 10.1016/j.exer.2012.04.004 contributor: fullname: Samardzija – volume: 276 start-page: 23000 year: 2001 ident: 10.1016/j.exer.2019.03.007_bib17 article-title: Light-induced photoreceptor apoptosis in vivo requires neuronal nitric-oxide synthase and guanylate cyclase activity and is caspase-3-independent publication-title: J. Biol. Chem. doi: 10.1074/jbc.M005359200 contributor: fullname: Donovan – volume: 32 start-page: 6981 year: 2012 ident: 10.1016/j.exer.2019.03.007_bib60 article-title: Light-driven calcium signals in mouse cone photoreceptors publication-title: J. Neurosci. doi: 10.1523/JNEUROSCI.6432-11.2012 contributor: fullname: Wei – volume: 291 start-page: 4698 year: 2016 ident: 10.1016/j.exer.2019.03.007_bib19 article-title: Phototransduction influences metabolic flux and nucleotide metabolism in mouse retina publication-title: J. Biol. Chem. doi: 10.1074/jbc.M115.698985 contributor: fullname: Du – volume: 293 start-page: 15332 year: 2018 ident: 10.1016/j.exer.2019.03.007_bib59 article-title: The PDE6 mutation in the rd10 retinal degeneration mouse model causes protein mislocalization and instability and promotes cell death through increased ion influx publication-title: J. Biol. Chem. doi: 10.1074/jbc.RA118.004459 contributor: fullname: Wang – volume: 19 start-page: 2579 year: 2013 ident: 10.1016/j.exer.2019.03.007_bib29 article-title: Review: the history and role of naturally occurring mouse models with Pde6b mutations publication-title: Mol. Vis. contributor: fullname: Han – volume: 808 start-page: 93 year: 2018 ident: 10.1016/j.exer.2019.03.007_bib49 article-title: Replication stress in mitochondria publication-title: Mutat. Res. doi: 10.1016/j.mrfmmm.2018.01.005 contributor: fullname: Ricchetti – volume: 10 start-page: 925 year: 2010 ident: 10.1016/j.exer.2019.03.007_bib9 article-title: Using 'omics' to define pathogenesis and biomarkers of Parkinson's disease publication-title: Expert Rev. Neurother. doi: 10.1586/ern.10.54 contributor: fullname: Caudle – volume: 61 start-page: 651 year: 2013 ident: 10.1016/j.exer.2019.03.007_bib48 article-title: New functions of Müller cells publication-title: Glia doi: 10.1002/glia.22477 contributor: fullname: Reichenbach – volume: 962 start-page: 318 year: 2002 ident: 10.1016/j.exer.2019.03.007_bib37 article-title: Role of nitric oxide in inflammation-mediated neurodegeneration publication-title: Ann. N. Y. Acad. Sci. doi: 10.1111/j.1749-6632.2002.tb04077.x contributor: fullname: Liu – volume: 115 start-page: E2997 year: 2018 ident: 10.1016/j.exer.2019.03.007_bib58 article-title: Combination of cGMP analogue and drug delivery system provides functional protection in hereditary retinal degeneration publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.1718792115 contributor: fullname: Vighi – volume: 23 start-page: 1537 year: 2002 ident: 10.1016/j.exer.2019.03.007_bib4 article-title: Mutation, DNA strand cleavage and nitric oxide formation caused by N-nitrosoproline with sunlight: a possible mechanism of UVA carcinogenicity publication-title: Carcinogenesis doi: 10.1093/carcin/23.9.1537 contributor: fullname: Arimoto-Kobayashi – year: 2014 ident: 10.1016/j.exer.2019.03.007_bib23 contributor: fullname: Ferrier – volume: 21 start-page: 2294 year: 2007 ident: 10.1016/j.exer.2019.03.007_bib40 article-title: Maintaining precursor pools for mitochondrial DNA replication publication-title: FASEB J. doi: 10.1096/fj.06-7977rev contributor: fullname: Mathews – volume: 108 start-page: 796 year: 2009 ident: 10.1016/j.exer.2019.03.007_bib45 article-title: PKG activity causes photoreceptor cell death in two retinitis pigmentosa models publication-title: J. Neurochem. doi: 10.1111/j.1471-4159.2008.05822.x contributor: fullname: Paquet-Durand – volume: 6 start-page: 469 year: 2007 ident: 10.1016/j.exer.2019.03.007_bib56 article-title: Chemometrics in metabonomics publication-title: J. Proteome Res. doi: 10.1021/pr060594q contributor: fullname: Trygg – volume: 212 start-page: 379 year: 2016 ident: 10.1016/j.exer.2019.03.007_bib41 article-title: Metabolic regulation of mitochondrial dynamics publication-title: J. Cell Biol. doi: 10.1083/jcb.201511036 contributor: fullname: Mishra – volume: 350 start-page: 9 year: 1994 ident: 10.1016/j.exer.2019.03.007_bib34 article-title: Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients publication-title: FEBS Lett. doi: 10.1016/0014-5793(94)00722-5 contributor: fullname: Kaur – volume: 101 start-page: 4308 year: 2004 ident: 10.1016/j.exer.2019.03.007_bib8 article-title: Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo publication-title: Proc. Natl. Acad. Sci. U. S. A. doi: 10.1073/pnas.0306706101 contributor: fullname: Bryan – volume: 18 start-page: 1917 year: 2008 ident: 10.1016/j.exer.2019.03.007_bib42 article-title: ATP consumption by mammalian rod photoreceptors in darkness and in light publication-title: Curr. Biol. doi: 10.1016/j.cub.2008.10.029 contributor: fullname: Okawa – volume: 131 start-page: 1075 year: 2006 ident: 10.1016/j.exer.2019.03.007_bib51 article-title: A pragmatic and readily implemented quality control strategy for HPLC-MS and GC-MS-based metabonomic analysis publication-title: Analyst doi: 10.1039/b604498k contributor: fullname: Sangster – volume: 11 start-page: 872 year: 2010 ident: 10.1016/j.exer.2019.03.007_bib61 article-title: Mitochondrial fusion and fission in cell life and death publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3013 contributor: fullname: Westermann |
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Snippet | Retinitis pigmentosa (RP) is a degenerative disease of the retina that affects approximately 1 million people worldwide. There are multiple genetic causes of... |
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SubjectTerms | Animals Chromatography, High Pressure Liquid Deoxynucleotide Disease Models, Animal Mass Spectrometry Metabolic Networks and Pathways - physiology Metabolome - physiology Metabolomics Mice Mice, Inbred C57BL Nitric oxide Nitrosamines - metabolism Purine Nucleotides - metabolism Pyrimidines - metabolism Retinal degeneration Retinitis Pigmentosa - metabolism UPLC-TOF-MS |
Title | Broad spectrum metabolomics for detection of abnormal metabolic pathways in a mouse model for retinitis pigmentosa |
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