Microbiota Gut–Brain Axis in Ischemic Stroke: A Narrative Review with a Focus about the Relationship with Inflammatory Bowel Disease

The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer’s disease, and Parkinson’s disease. The complex interplay between gut microbiota and the brain, and vice versa, has recently become not only the focus of neuro...

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Published inLife (Basel, Switzerland) Vol. 11; no. 7; p. 715
Main Authors Sinagra, Emanuele, Pellegatta, Gaia, Guarnotta, Valentina, Maida, Marcello, Rossi, Francesca, Conoscenti, Giuseppe, Pallio, Socrate, Alloro, Rita, Raimondo, Dario, Pace, Fabio, Anderloni, Andrea
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 19.07.2021
MDPI
Subjects
Aging
Alzheimer's disease
Blood pressure
Brain
gut
Hypertension
Hypothalamus
Inflammatory bowel disease
Inflammatory bowel diseases
Intestinal microflora
Intestine
Ischemia
Metabolic disorders
Metabolites
Microbiota
Movement disorders
Nervous system
Neurodegenerative diseases
Parkinson's disease
Physiology
Review
Stroke
Online AccessGet full text
ISSN2075-1729
2075-1729
DOI10.3390/life11070715

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Abstract The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer’s disease, and Parkinson’s disease. The complex interplay between gut microbiota and the brain, and vice versa, has recently become not only the focus of neuroscience, but also the starting point for research regarding many diseases such as inflammatory bowel diseases (IBD). The bi-directional interaction between gut microbiota and the brain is not completely understood. The aim of this review is to sum up the evidencesconcerningthe role of the gut–brain microbiota axis in ischemic stroke and to highlight the more recent evidences about the potential role of the gut–brain microbiota axis in the interaction between inflammatory bowel disease and ischemic stroke.
AbstractList The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer’s disease, and Parkinson’s disease. The complex interplay between gut microbiota and the brain, and vice versa, has recently become not only the focus of neuroscience, but also the starting point for research regarding many diseases such as inflammatory bowel diseases (IBD). The bi-directional interaction between gut microbiota and the brain is not completely understood. The aim of this review is to sum up the evidencesconcerningthe role of the gut–brain microbiota axis in ischemic stroke and to highlight the more recent evidences about the potential role of the gut–brain microbiota axis in the interaction between inflammatory bowel disease and ischemic stroke.
The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer's disease, and Parkinson's disease. The complex interplay between gut microbiota and the brain, and vice versa, has recently become not only the focus of neuroscience, but also the starting point for research regarding many diseases such as inflammatory bowel diseases (IBD). The bi-directional interaction between gut microbiota and the brain is not completely understood. The aim of this review is to sum up the evidencesconcerningthe role of the gut-brain microbiota axis in ischemic stroke and to highlight the more recent evidences about the potential role of the gut-brain microbiota axis in the interaction between inflammatory bowel disease and ischemic stroke.The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer's disease, and Parkinson's disease. The complex interplay between gut microbiota and the brain, and vice versa, has recently become not only the focus of neuroscience, but also the starting point for research regarding many diseases such as inflammatory bowel diseases (IBD). The bi-directional interaction between gut microbiota and the brain is not completely understood. The aim of this review is to sum up the evidencesconcerningthe role of the gut-brain microbiota axis in ischemic stroke and to highlight the more recent evidences about the potential role of the gut-brain microbiota axis in the interaction between inflammatory bowel disease and ischemic stroke.
Author Pellegatta, Gaia
Anderloni, Andrea
Maida, Marcello
Pallio, Socrate
Rossi, Francesca
Alloro, Rita
Pace, Fabio
Conoscenti, Giuseppe
Guarnotta, Valentina
Raimondo, Dario
Sinagra, Emanuele
AuthorAffiliation 4 Endocrinology Section, PROMISE Department, AOUP Paolo Giaccone, 90127 Palermo, Italy; valentinaguarnotta@gmail.com
8 Unit of Gastroenterology, Bolognini Hospital, 24100 Bergamo, Italy; fabio.pace@unimi.it
1 Endoscopy Unit, Fondazione Istituto San Raffaele—G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy; fraross76@hotmail.com (F.R.); dottgconoscenti@gmail.com (G.C.); ritalloro@hotmail.it (R.A.); dario.raimondo@hsrgiglio.it (D.R.)
3 Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, 20089 Rozzano, Italy; gaia.pellegatta@humanitas.it (G.P.); andrea_anderloni@hotmail.com (A.A.)
5 Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, 93100 Caltanissetta, Italy; marcello.maida@hotmail.it
2 Euro-Mediterranean Institute of Science and Technology (IEMEST), 90100 Palermo, Italy
7 Emergency Unit, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy
6 Endoscopy Unit, Department of clinical and experimenta
AuthorAffiliation_xml – name: 6 Endoscopy Unit, Department of clinical and experimental medicine, University of Messina, AOUP Policlinico G. Martino, 98125 Messina, Italy; socratep@tin.it
– name: 4 Endocrinology Section, PROMISE Department, AOUP Paolo Giaccone, 90127 Palermo, Italy; valentinaguarnotta@gmail.com
– name: 2 Euro-Mediterranean Institute of Science and Technology (IEMEST), 90100 Palermo, Italy
– name: 3 Digestive Endoscopy Unit, Division of Gastroenterology, Humanitas Research Hospital, 20089 Rozzano, Italy; gaia.pellegatta@humanitas.it (G.P.); andrea_anderloni@hotmail.com (A.A.)
– name: 7 Emergency Unit, Fondazione Istituto G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy
– name: 1 Endoscopy Unit, Fondazione Istituto San Raffaele—G. Giglio, Contrada Pietra Pollastra Pisciotto, 90015 Cefalù, Italy; fraross76@hotmail.com (F.R.); dottgconoscenti@gmail.com (G.C.); ritalloro@hotmail.it (R.A.); dario.raimondo@hsrgiglio.it (D.R.)
– name: 5 Gastroenterology and Endoscopy Unit, S. Elia-Raimondi Hospital, 93100 Caltanissetta, Italy; marcello.maida@hotmail.it
– name: 8 Unit of Gastroenterology, Bolognini Hospital, 24100 Bergamo, Italy; fabio.pace@unimi.it
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Snippet The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer’s disease, and...
The gut microbiota is emerging as an important player in neurodevelopment and aging as well as in brain diseases including stroke, Alzheimer's disease, and...
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SubjectTerms Aging
Alzheimer's disease
Blood pressure
Brain
gut
Hypertension
Hypothalamus
Inflammatory bowel disease
Inflammatory bowel diseases
Intestinal microflora
Intestine
Ischemia
Metabolic disorders
Metabolites
Microbiota
Movement disorders
Nervous system
Neurodegenerative diseases
Parkinson's disease
Physiology
Review
Stroke
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Title Microbiota Gut–Brain Axis in Ischemic Stroke: A Narrative Review with a Focus about the Relationship with Inflammatory Bowel Disease
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Volume 11
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