Indirubin inhibits tumor growth by antitumor angiogenesis via blocking VEGFR2‐mediated JAK/STAT3 signaling in endothelial cell

• Published in: International journal of cancer Vol. 129; no. 10; pp. 2502 - 2511
• Main Authors: Zhang, Xiaoli, Song, Yajuan, Wu, Yuanyuan, Dong, Yanmin, Lai, Li, Zhang, Jing, Lu, Binbin, Dai, Fujun, He, Lijun, Liu, Mingyao, Yi, Zhengfang
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 15.11.2011; Wiley-Blackwell
• Subjects: Angiogenesis Inhibitors - pharmacology; Animals; Antibiotics, Antineoplastic - pharmacology; Biological and medical sciences; Cell Line; Cell Line, Tumor; Endothelial Cells - metabolism; Humans; indirubin; Indoles - pharmacology; JAK/STAT3; Janus Kinases - metabolism; Male; Medical sciences; Mice; Prostatic Neoplasms - blood supply; Prostatic Neoplasms - drug therapy; Signal Transduction - drug effects; STAT3 Transcription Factor - metabolism; tumor angiogenesis,VEGFR2; Tumors; Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors; Xenograft Model Antitumor Assays; Antineoplastic agent; Jak protein tyrosine kinase; VEGFR2; Endothelial cell; Malignant tumor; JAK/STAT3; Angiogenesis; Signal transduction; indirubin; Cancerology; Tumor growth; Transcription factor STAT3; tumor angiogenesis; Inhibitor; Neovascularization; Vascular endothelial growth factor receptor 2; Cancer

Tumor angiogenesis is one of the hallmarks of the development in malignant neoplasias and metastasis. Many angiogenesis inhibitors are small molecules from natural products. Indirubin, the active component of a traditional Chinese herbal medicine, Banlangen, has been shown to exhibit antitumor and a...