In vivo activation of gelatinase B/MMP-9 by trypsin in acute pancreatitis is a permissive factor in streptozotocin-induced diabetes

• Published in: The Journal of pathology Vol. 204; no. 5; pp. 555 - 561
• Main Authors: Descamps, Francis J, Martens, Erik, Ballaux, Florence, Geboes, Karel, Opdenakker, Ghislain
• Format: Journal Article
• Language: English
• Published: Chichester, UK John Wiley & Sons, Ltd 01.12.2004; Wiley
• Subjects: Acute Disease; Animals; Apoptosis - physiology; Biological and medical sciences; Blood Glucose - analysis; Ceruletide; diabetes; Diabetes Mellitus, Experimental - metabolism; Enzyme Activation - physiology; Gastroenterology. Liver. Pancreas. Abdomen; Investigative techniques, diagnostic techniques (general aspects); Islets of Langerhans - metabolism; Islets of Langerhans - physiopathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Matrix Metalloproteinase 2 - metabolism; Matrix Metalloproteinase 9 - blood; Matrix Metalloproteinase 9 - deficiency; Matrix Metalloproteinase 9 - metabolism; matrix metalloproteinase-9; Medical sciences; Mice; Mice, Inbred C57BL; Mice, Knockout; Necrosis - metabolism; Other diseases. Semiology; Pancreas, Exocrine - metabolism; Pancreas, Exocrine - physiopathology; pancreatitis; Pancreatitis - enzymology; Pancreatitis - metabolism; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; streptozotocin; trypsin; Trypsin - metabolism; Up-Regulation - physiology; Endocrinopathy; Animal model; Serine endopeptidases; Enzyme; matrix metalloproteinase-9; Acute; Diabetes mellitus; Pancreatitis; Metalloendopeptidases; Activation; Gelatinase B; Peptidases; In vivo; Anatomic pathology; Trypsin; Digestive diseases; Hydrolases; Streptozotocin; diabetes; Pancreatic disease

Matrix metalloproteinases, in particular gelatinase B/MMP‐9, are key mediators in autoimmune diseases like multiple sclerosis and rheumatoid arthritis, but their pathogenic roles in diabetes are not well established. Gelatinase B has previously been shown to be upregulated in pancreas tissue from pa...