Neurological and neurophysiological examinations on workers with chronic poisoning by 2,3,7,8-TCDD: follow-up 35 years after exposure

• Published in: European journal of neurology Vol. 14; no. 2; pp. 213 - 218
• Main Authors: Urban, P., Pelclová, D., Lukáš, E., Kupka, K., Preiss, J., Fenclová, Z., Šmerhovský, Z.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.02.2007
• Subjects: 2, 3, 7, 8‐TCDD; 8-TCDD; Central Nervous System Diseases - chemically induced; Central Nervous System Diseases - diagnosis; Cerebrovascular Disorders - diagnostic imaging; Chronic Disease; Color Vision Defects - chemically induced; Color Vision Defects - diagnosis; dioxin; Electroencephalography; Environmental Pollutants - blood; Environmental Pollutants - poisoning; Evoked Potentials, Visual - drug effects; Follow-Up Studies; Humans; Lanthony test; Male; Middle Aged; nerve conduction velocity; Nervous System Diseases - chemically induced; Nervous System Diseases - diagnosis; Neural Conduction; Neurologic Examination; Neuropsychological Tests; Occupational Diseases - diagnosis; Occupational Diseases - physiopathology; Occupational Diseases - psychology; Polychlorinated Dibenzodioxins - blood; Polychlorinated Dibenzodioxins - poisoning; Polyneuropathies - chemically induced; Polyneuropathies - diagnosis; Polyneuropathies - physiopathology; SPECT; Tomography, Emission-Computed, Single-Photon; toxic dyschromatopsia; toxic encephalopathy; toxic neuropathy; Visual-evoked potential

Between 1965 and 1968, about 350 workers were accidentally exposed to 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD) in a chemical plant, which was producing herbicides based on the trichlorophenoxyacetic acid. About 80 workers developed signs of poisoning. The estimated mean concentration of TCDD at th...