Examination of acetaminophen for outpatient management of postoperative pain in children
We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children. Forty children, 5–15 years of age, undergoing tonsillectomy and their parents were randomly assigned to use a scheduled administration of acetaminophen in weight appropriate doses, 60...
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Published in | Pediatric anesthesia Vol. 8; no. 3; pp. 235 - 239 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
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Oxford, UK
Blackwell Science Ltd
01.05.1998
Blackwell |
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Abstract | We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children. Forty children, 5–15 years of age, undergoing tonsillectomy and their parents were randomly assigned to use a scheduled administration of acetaminophen in weight appropriate doses, 60 mg·kg−1·24 h−1 orally, 90 mg·kg−1·24 h−1 rectally, or to use acetaminophen ‘as needed’ according to present standards (control group). Postoperative pain was assessed by the child using the poker chip tool for the first three days after discharge. The prevalence of pain amongst all the children was high. The second day after discharge 22%–64% of the children in the study group and 36%–73% of the children in the control group rated severe pain. Recommended dose ranges of acetaminophen do not provide sufficient pain relief in children following tonsillectomy. Further studies are required to determine, whether higher doses of acetaminophen or analgesics with different analgesic properties will lead to improved analgesia in children following tonsillectomy. |
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AbstractList | We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children. Forty children, 5–15 years of age, undergoing tonsillectomy and their parents were randomly assigned to use a scheduled administration of acetaminophen in weight appropriate doses, 60 mg·kg−1·24 h−1 orally, 90 mg·kg−1·24 h−1 rectally, or to use acetaminophen ‘as needed’ according to present standards (control group). Postoperative pain was assessed by the child using the poker chip tool for the first three days after discharge. The prevalence of pain amongst all the children was high. The second day after discharge 22%–64% of the children in the study group and 36%–73% of the children in the control group rated severe pain. Recommended dose ranges of acetaminophen do not provide sufficient pain relief in children following tonsillectomy. Further studies are required to determine, whether higher doses of acetaminophen or analgesics with different analgesic properties will lead to improved analgesia in children following tonsillectomy. We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children. Forty children, 5–15 years of age, undergoing tonsillectomy and their parents were randomly assigned to use a scheduled administration of acetaminophen in weight appropriate doses, 60 mg·kg −1 ·24 h −1 orally, 90 mg·kg −1 ·24 h −1 rectally, or to use acetaminophen ‘as needed’ according to present standards (control group). Postoperative pain was assessed by the child using the poker chip tool for the first three days after discharge. The prevalence of pain amongst all the children was high. The second day after discharge 22%–64% of the children in the study group and 36%–73% of the children in the control group rated severe pain. Recommended dose ranges of acetaminophen do not provide sufficient pain relief in children following tonsillectomy. Further studies are required to determine, whether higher doses of acetaminophen or analgesics with different analgesic properties will lead to improved analgesia in children following tonsillectomy. We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children. Forty children, 5-15 years of age, undergoing tonsillectomy and their parents were randomly assigned to use a scheduled administration of acetaminophen in weight appropriate doses, 60 mg.kg-1.24h-1 orally, 90 mg.kg-1.24h-1 rectally, or to use acetaminophen 'as needed' according to present standards (control group). Postoperative pain was assessed by the child using the poker chip tool for the first three days after discharge. The prevalence of pain amongst all the children was high. The second day after discharge 22%-64% of the children in the study group and 36%-73% of the children in the control group rated severe pain. Recommended dose ranges of acetaminophen do not provide sufficient pain relief in children following tonsillectomy. Further studies are required to determine, whether higher doses of acetaminophen or analgesics with different analgesic properties will lead to improved analgesia in children following tonsillectomy. |
Author | HARDER, ANNE HERTEL, STEEN RØMSING, JANNE RASMUSSEN, METTE |
Author_xml | – sequence: 1 givenname: JANNE surname: RØMSING fullname: RØMSING, JANNE organization: Department of Pharmaceutics, The Royal Danish School of Pharmacy, Copenhagen, Denmark – sequence: 2 givenname: STEEN surname: HERTEL fullname: HERTEL, STEEN organization: Department of Pediatrics, The State University Hospital, Copenhagen, Denmark – sequence: 3 givenname: ANNE surname: HARDER fullname: HARDER, ANNE organization: Department of Ear, Nose and Throat, The County Hospital of Roskilde, Roskilde, Denmark – sequence: 4 givenname: METTE surname: RASMUSSEN fullname: RASMUSSEN, METTE organization: Department of Pharmaceutics, The Royal Danish School of Pharmacy, Copenhagen, Denmark |
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Cites_doi | 10.1016/S0882-5963(96)80069-8 10.1207/s15326888chc1604_5 10.1016/0304-3959(95)00091-7 10.1007/BF03008781 10.1007/BF03011069 10.1111/j.1460-9592.1994.tb00121.x 10.1007/BF03010655 10.1097/01241398-198701000-00016 |
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Keywords | Human Postoperative Oral administration Rectal administration Dose activity relation Analgesia Chemotherapy Paracetamol Analgesic Pain Treatment Tonsillectomy Surgery ENT disease Application method Ambulatory Child Comparative study |
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References_xml | – volume: 39 start-page: 226 year: 1992 end-page: 230 article-title: Efficacy of rectal ibuprofen in controlling postoperative pain in children publication-title: Can J Anaesth – volume: 16 start-page: 274 year: 1988 end-page: 282 article-title: The convergent and discriminant validity of a self‐report measure of pain intensity for children publication-title: Child Health Care – volume: 21 start-page: 341 year: 1995 end-page: 344 article-title: Quality improvement study of day surgery for tonsillectomy and adenoidectomy patients publication-title: Ped Nurs – volume: 28 start-page: 250 year: 1979 end-page: 255 article-title: The preoperational child's reaction to immunization publication-title: Nurs Res – volume: 83 start-page: A1126 year: 1995 article-title: Pharmacokinetics of a higher dose of rectal acetaminophen in children publication-title: Anesthesiol – volume: 64 start-page: 83 year: 1996 end-page: 87 article-title: Parents’ management of children's pain following ‘minor’ surgery publication-title: Pain – volume: 107 start-page: 451 year: 1994 end-page: 452 article-title: Parental attitudes and postoperative problems related to paediatric day stay tonsillectomy publication-title: NZ Med J – volume: 35 start-page: 149 year: 1988 end-page: 152 article-title: Pharmacokinetics and clinical efficacy of intrarectal solution of acetaminophen publication-title: Can J Anaesth – volume: 4 start-page: 45 year: 1994 end-page: 51 article-title: Post‐operative pain in children after day case surgery publication-title: Paediatr Anaesth – volume: 21 start-page: 159 year: 1996 end-page: 163 article-title: Assessment of nurses’ judgement for analgesic requirements of postoperative children publication-title: J Clin Pharm – volume: 85 start-page: A1105 year: 1996 article-title: ‘Loading’ and subsequent dosing of rectal acetaminophen in children: a 24 hour pharmacokinetic study of new dose recommendations publication-title: Anesthesiol – volume: 15 start-page: 79 year: 1990 end-page: 84 article-title: Measurement of pain in children: generalizability and validity of the pain ladder and the poker chip tool publication-title: In: Tyler DC, Krane EJ, eds. Advances in pain research and therapy. New York: Raven Press – volume: 7 start-page: 78 year: 1987 end-page: 82 article-title: Oral morphine versus injected meperidine (Demerol) for pain relief in children after orthopedic surgery publication-title: J Ped Orthop – volume: 42 start-page: 982 year: 1995 end-page: 986 article-title: Plasma concentrations after high‐dose (45 mg/kg) rectal acetaminophen in children publication-title: Can J Anaesth – volume: 11 start-page: 119 year: 1996 end-page: 124 article-title: Postoperative pain in Danish children: self‐report measures of pain intensity publication-title: J Pediatr Nurs – volume: 21 start-page: 341 year: 1995 ident: e_1_2_2_4_2 article-title: Quality improvement study of day surgery for tonsillectomy and adenoidectomy patients publication-title: Ped Nurs contributor: fullname: Norinkavich KM – volume: 15 start-page: 79 year: 1990 ident: e_1_2_2_9_2 article-title: Measurement of pain in children: generalizability and validity of the pain ladder and the poker chip tool publication-title: In: Tyler DC, Krane EJ, eds. Advances in pain research and therapy. New York: Raven Press contributor: fullname: Hester NO – ident: e_1_2_2_11_2 doi: 10.1016/S0882-5963(96)80069-8 – ident: e_1_2_2_10_2 doi: 10.1207/s15326888chc1604_5 – ident: e_1_2_2_5_2 doi: 10.1016/0304-3959(95)00091-7 – ident: e_1_2_2_7_2 doi: 10.1007/BF03008781 – ident: e_1_2_2_14_2 doi: 10.1007/BF03011069 – volume: 107 start-page: 451 year: 1994 ident: e_1_2_2_2_2 article-title: Parental attitudes and postoperative problems related to paediatric day stay tonsillectomy publication-title: NZ Med J contributor: fullname: Bartley JR – ident: e_1_2_2_3_2 doi: 10.1111/j.1460-9592.1994.tb00121.x – ident: e_1_2_2_12_2 doi: 10.1007/BF03010655 – ident: e_1_2_2_6_2 doi: 10.1097/01241398-198701000-00016 – volume: 28 start-page: 250 year: 1979 ident: e_1_2_2_8_2 article-title: The preoperational child's reaction to immunization publication-title: Nurs Res contributor: fullname: Hester NO – volume: 21 start-page: 159 year: 1996 ident: e_1_2_2_13_2 article-title: Assessment of nurses’ judgement for analgesic requirements of postoperative children publication-title: J Clin Pharm contributor: fullname: Rømsing J – volume: 83 start-page: A1126 year: 1995 ident: e_1_2_2_15_2 article-title: Pharmacokinetics of a higher dose of rectal acetaminophen in children publication-title: Anesthesiol contributor: fullname: Houck CS – volume: 85 start-page: A1105 year: 1996 ident: e_1_2_2_16_2 article-title: ‘Loading’ and subsequent dosing of rectal acetaminophen in children: a 24 hour pharmacokinetic study of new dose recommendations publication-title: Anesthesiol contributor: fullname: Birmingham P |
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Snippet | We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children. Forty children, 5–15 years of age,... We have examined acetaminophen (paracetamol) dosing for outpatient management of posttonsillectomy pain in children. Forty children, 5-15 years of age,... |
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SubjectTerms | acetaminophen Acetaminophen - administration & dosage Acetaminophen - adverse effects Acetaminophen - therapeutic use Administration, Oral Administration, Rectal Adolescent Ambulatory Care analgesia Analgesics Analgesics - administration & dosage Analgesics - therapeutic use Analgesics, Non-Narcotic - administration & dosage Analgesics, Non-Narcotic - adverse effects Analgesics, Non-Narcotic - therapeutic use Biological and medical sciences Body Weight Child Child, Preschool Drug Administration Schedule Female Follow-Up Studies Humans Male Medical sciences Neuropharmacology Pain Measurement Pain, Postoperative - drug therapy Pain, Postoperative - prevention & control Patient Discharge Pharmacology. Drug treatments postoperative tonsillectomy Tonsillectomy - adverse effects |
Title | Examination of acetaminophen for outpatient management of postoperative pain in children |
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