Characterization of humoral and SARS-CoV-2 specific T cell responses in people living with HIV

• Published in: Nature communications Vol. 12; no. 1; pp. 5839 - 16
• Main Authors: Alrubayyi, Aljawharah, Gea-Mallorquí, Ester, Touizer, Emma, Hameiri-Bowen, Dan, Kopycinski, Jakub, Charlton, Bethany, Fisher-Pearson, Natasha, Muir, Luke, Rosa, Annachiara, Roustan, Chloe, Earl, Christopher, Cherepanov, Peter, Pellegrino, Pierre, Waters, Laura, Burns, Fiona, Kinloch, Sabine, Dong, Tao, Dorrell, Lucy, Rowland-Jones, Sarah, McCoy, Laura E., Peppa, Dimitra
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 05.10.2021; Nature Publishing Group; Nature Portfolio
• Subjects: 13; 13/1; 13/106; 13/21; 13/31; 631/250/2152/1566/1571; 631/250/2152/2153/1291; 631/250/255/2514; 631/326/596/4130; Adaptive immunity; Adult; Aged; Antibodies, Viral - blood; Antibodies, Viral - immunology; Antibody Formation - immunology; Antigens, Viral - immunology; Antiretroviral therapy; CD4 antigen; CD4-Positive T-Lymphocytes - immunology; CD8 antigen; CD8-Positive T-Lymphocytes - immunology; Cohort Studies; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 - virology; Female; Genome, Human; HIV; HIV Infections - blood; HIV Infections - immunology; HIV Infections - virology; Human immunodeficiency virus; Humanities and Social Sciences; Humans; Immune reconstitution; Immune response; Immune response (humoral); Immune system; Immunity, Humoral; Immunology; Interferon-gamma - metabolism; Lymphocytes; Lymphocytes T; Male; Middle Aged; multidisciplinary; Patients; Phenotype; SARS-CoV-2 - physiology; Science; Science (multidisciplinary); Severe acute respiratory syndrome coronavirus 2; Species Specificity; T-Lymphocytes - immunology; Tissue Donors; Vaccine efficacy; Viral diseases

There is an urgent need to understand the nature of immune responses against SARS-CoV-2, to inform risk-mitigation strategies for people living with HIV (PLWH). Here we show that the majority of PLWH with ART suppressed HIV viral load, mount a detectable adaptive immune response to SARS-CoV-2. Humor...