Inhibition of platelet activation prevents the P‐selectin and integrin‐dependent accumulation of cancer cell microparticles and reduces tumor growth and metastasis in vivo

• Published in: International journal of cancer Vol. 136; no. 2; pp. 462 - 475
• Main Authors: Mezouar, Soraya, Darbousset, Roxane, Dignat‐George, Françoise, Panicot‐Dubois, Laurence, Dubois, Christophe
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 15.01.2015; Wiley
• Subjects: Animals; Blood Coagulation; Blotting, Western; Cancer; Cell-Derived Microparticles - metabolism; Disease Models, Animal; Flow Cytometry; Fluorescent Antibody Technique; Integrins - metabolism; Life Sciences; Medical research; Medication; Metastasis; Mice; Mice, Inbred C57BL; microparticles; Neoplasm Metastasis; P-Selectin - metabolism; Pancreatic cancer; Pancreatic Neoplasms - complications; Pancreatic Neoplasms - pathology; Pancreatic Neoplasms - prevention & control; Pharmaceutical sciences; Platelet Activation; Platelet Aggregation Inhibitors - therapeutic use; platelets; Prescription drugs; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; RNA, Messenger - genetics; Thromboplastin - antagonists & inhibitors; Thromboplastin - metabolism; Thrombosis; Thrombosis - etiology; Thrombosis - pathology; Thrombosis - prevention & control; Ticlopidine - analogs & derivatives; Ticlopidine - therapeutic use; tissue factor; Tumor Cells, Cultured; microparticles; pancreatic cancer; thrombosis; tissue factor; platelets

Venous thromboembolism constitutes one of the main causes of death during the progression of a cancer. We previously demonstrated that tissue factor (TF)‐bearing cancer cell‐derived microparticles accumulate at the site of injury in mice developing a pancreatic cancer. The presence of these micropar...